Hydroxypropyl methyl cellulose HPMC imhando ye-non-ionic cellulose yakasanganiswa ether, yakasiyana neionic methyl carboxymethyl cellulose yakasanganiswa ether, uye haibatike nesimbi inorema.Nekuda kwekusiyana kwakasiyana kwemethoxyl yemukati uye hydroxypropyl yemukati mune hydroxypropyl methylcellulose uye akasiyana viscosities, yave mhando dzakasiyana dzine hunhu hwakasiyana, semuenzaniso, yakakwira methoxyl yemukati uye yakaderera hydroxypropyl zvemukati Kuita kwayo kuri pedyo neiyo methyl cellulose, iyo mhando ine yakaderera methoxyl yemukati uye yakakwira hydroxypropyl yemukati, kuita kwayo kuri pedyo neiyo yehydroxypropyl methylcellulose.Nekudaro, mumhando dzakasiyana siyana, kunyangwe ishoma chete yeboka rehydroxypropyl kana chikamu chidiki chemethoxy boka chirimo, kunyungudika mune organic solvents kana tembiricha yeflocculation mune aqueous solution zvakasiyana kwazvo.
1. Kunyungudika kwehydroxypropyl methylcellulose
①Solubility yehydroxypropyl methyl cellulose mumvura Hydroxypropyl methyl cellulose ichokwadi methyl cellulose yakagadziridzwa nepropylene oxide (methyl oxypropylene), saka ichine zvimiro zvakafanana nemethyl cellulose.Cellulose yakafanana mukunyungudika kwemvura inotonhora uye kusagadziriswa kwemvura inopisa.Nekudaro, nekuda kweiyo yakagadziridzwa hydroxypropyl boka, iyo gelation tembiricha mumvura inopisa yakakwira zvakanyanya kupfuura iyo yemethyl cellulose.Semuenzaniso, viscosity yeaqueous solution yehydroxypropyl methylcellulose ine 2% methoxyl content DS=0.73 uye hydroxypropyl content MS=0.46 is 500 mpa?s pa20°C.Kupisa kwayo gel Inogona kusvika padyo ne100 ° C, nepo methylcellulose patembiricha imwe chete inenge 55 ° C.Kana iri yekunyungudika kwayo mumvura, yakagadziridzwawo zvakanyanya.Semuyenzaniso, iyo pulverized hydroxypropyl methylcellulose (granular shape ye 0.2 ~ 0.5mm pa 20°C ine viscosity ye 4% aqueous solution inosvika 2pa?s inogona kushandiswa MuPamba tembiricha, inonyungudika nyore nyore mumvura isina kutonhora.
②Kunyungudika kwehydroxypropyl methyl cellulose muorganic solvents Kunyungudika kwehydroxypropyl methyl cellulose mumaorganic solvents zvakare kuri nani pane kuya kwemethyl cellulose, uye methyl cellulose inoda kuve nedhigirii remethoxyl inotsiva paZvigadzirwa zviri pamusoro pe2.1, uye yakakwirira-viscosity ine methylcellulose hydroxypropyl MS=1.5 ~ 1.8 uye methoxy DS=0.2 ~ 1.0, uye yakazara substitution dhigirii pamusoro 1.8 inonyungudika mu anhydrous methanol uye ethanol solutions medium, thermoplastic uye mvura-soluble.Inonyungudika zvakare mu chlorinated hydrocarbons senge dichloromethane uye chloroform, uye mune organic solvents senge acetone, isopropanol uye diacetone doro.Kunyungudika kwayo muorganic solvents kuri nani pane kunyungudika nemvura.
2. Zvinhu zvinokanganisa viscosity yehydroxypropyl methylcellulose
Kufurira zvinhu zve hydroxypropyl methyl cellulose viscosity Iyo yakajairwa viscosity kutsunga yehydroxypropyl methyl cellulose, semamwe ma cellulose ethers, yakavakirwa pamushonga we 2% ane aqueous pa 20°C.Iyo viscosity yechigadzirwa chimwe chete inowedzera nekuwedzera kwekutarisa.Kune zvigadzirwa zvine huremu hwakasiyana hwemamorekuru panguva imwe chete, zvigadzirwa zvine uremu hukuru hwemamorekuru zvine viscosity yakakwirira.Hukama hwayo nekupisa hwakafanana neyemethyl cellulose.Kana kutonhora kunowedzera, viscosity inotanga kuderera, asi kana inosvika kune imwe tembiricha, viscosity inongoerekana yawedzera uye gelation inoitika.Iyo tembiricha yegel yezvinhu zvakaderera-viscosity yakakwira.zvakakwirira.Iyo gel point haina kungoenderana chete neiyo viscosity ye ether, asiwo kune kuumbwa chiyero che methoxy uye hydroxypropyl mu ether uye iyo yakazara dhigirii yekutsiva.Izvo zvinofanirwa kucherechedzwa kuti hydroxypropyl methylcellulose zvakare pseudoplastic uye mhinduro yayo yakagadzikana pakamuri tembiricha pasina kushatisa kweviscosity kunze kwekugona kukanganisa enzymatic.
3. Hydroxypropyl methylcellulose acid uye alkali resistance
Hydroxypropyl methylcellulose acid uye alkali resistance Hydroxypropyl methylcellulose inowanzogadzikana kune asidhi uye alkali, uye haina kukanganiswa muhuwandu hwepH 2 ~ 12.Inogona kumira imwe chiyero cheasidhi yechiedza.Zvakadai sefomic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, etc. Zvisinei, concentrated acid ine simba rekuderedza viscosity.Alkali yakadai se caustic soda, caustic potash uye lime mvura haina simba pairi, asi inogona kuwedzera zvishoma viscosity yemhinduro, uye ipapo pachava nechiitiko chekuderera kunononoka mune ramangwana.
4. Kusanganiswa kwehydroxypropyl methylcellulose
Miscibility yeHydroxypropyl Methyl Cellulose Hydroxypropyl methyl cellulose solution inogona kusanganiswa nemvura-soluble polymer compound kuti ive yunifomu uye yakajeka mhinduro ine viscosity yakakwirira.Aya mapolymer compounds anosanganisira polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose uye methyl cellulose.Natural polymer komisheni senge gum arabic, mhashu bhinzi chingamu, karaya chingamu, nezvimwewo zvinewo musanganiswa wakanaka nemhinduro yayo.Hydroxypropyl methylcellulose inogonawo kusanganiswa nemannitol kana sorbitol esters ye stearic acid kana palmitic acid, uye inogonawo kusanganiswa ne glycerin, sorbitol uye mannitol.Izvi zvinosanganiswa zvinogona kushandiswa se hydroxypropyl methylcellulose.Cellulose-based plasticizer.
5. Insolubility uye mvura solubility yehydroxypropyl methylcellulose
Iyo insolubilized-soluble water-soluble cellulose ethers yehydroxypropyl methylcellulose inogona kuve pamusoro-yakabatana nealdehydes, uye aya ether-soluble ethers anodururwa mumushonga uye anove asina kunyungudika mumvura.Iyo aldehydes inoita hydroxypropyl methylcellulose insoluble inosanganisira formaldehyde, glyoxal, succinaldehyde, adipaldehyde, etc. Paunenge uchishandisa formaldehyde, kunyanya kukoshesa kunofanira kubhadharwa kune pH kukosha kwemhinduro, pakati peiyo glyoxal inokurumidza kukurumidza.Naizvozvo, glyoxal inowanzo shandiswa seyakachinjika mumiriri mukugadzirwa kwemaindasitiri.Chiyero chemhando iyi ye crosslinking agent mumhinduro ndeye 0.2% ~ 10% ye ether mass, zvichida 7% ~ 10%, uye 3.3% ~ 6% ndiyo inonyanya kukodzera glyoxal.Iyo yakawanda yekurapa tembiricha ndeye 0 ~ 30 ℃, uye nguva iri 1 ~ 120min.Iyo yekuyambuka-inobatanidza reaction inoda kuitwa pasi pemamiriro e acidic.Kazhinji, inorganic yakasimba asidhi kana organic carboxylic acid inowedzerwa kune mhinduro kugadzirisa pH yemhinduro kusvika 2 ~ 6, zviri nani pakati pe4 ~ 6, uyezve aldehydes inowedzerwa kuita muchinjiko-inobatanidza maitiro..Maasidhi anoshandiswa anosanganisira hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid kana citric acid, pakati peiyo formic acid kana acetic acid yakakodzera, uye formic acid ndiyo yakanyanya kunaka.Iyo asidhi uye aldehyde inogona zvakare kuwedzerwa panguva imwe chete kubvumira mhinduro kuyambuka mune inodiwa pH renji.Kuita uku kunowanzo shandiswa mukugadzirisa kwekupedzisira kwekurapa mugadziriro yekugadzira cellulose ethers.Mushure mekunge cellulose ether isina kunyungudika, zviri nyore kugeza uye kuchenesa nemvura pa20 ~ 25 ° C.Kana chigadzirwa chacho chiri kushandiswa, chinhu che alkaline chinogona kuwedzerwa kune mhinduro yechigadzirwa kugadzirisa pH yemhinduro kuti ive alkaline, uye chigadzirwa chichanyunguduka mumhinduro nokukurumidza.Iyi nzira inoshandiswawo kune cellulose ether solution yakagadzirwa mufirimu uye ipapo firimu rinogadziriswa kuti riite firimu risinganyunguriki.
6. Hydroxypropyl methylcellulose inopesana nema enzymes
Hydroxypropyl methylcellulose inopesana nema enzymes.Muchirevo, zvinyorwa zve cellulose, zvakadai seboka rimwe nerimwe reanhydroglucose, rine boka rakanyatsobatanidzwa rinotsiva, izvo zvisiri nyore kutapukirwa nema microorganisms, asi chaizvoizvo chigadzirwa chakapedzwa Kana kukosha kwekutsiva kunopfuura 1, kuchave kwakasvibiswawo nema enzymes. izvo zvinoreva kuti dhigirii yekutsiviwa kweboka rega rega pacheni ye cellulose haina yunifomu yakakwana, uye tupukanana tunogona kunyura pedyo neasina kutsiva anhydroglucose mapoka kuti aumbe shuga., iyo inotorwa sechikafu chemicroorganisms.Naizvozvo, kana iyo etherification inotsiva dhigirii ye cellulose ichiwedzera, kuramba kukukurwa kwe enzymatic ye cellulose ether kunowedzerwa zvakare.Zvinonzi yakasara viscosity ye hydroxypropyl methylcellulose (DS = 1.9) ndeye 13.2%, methylcellulose (DS = 1.83) ndeye 7.3%, uye methylcellulose (DS = 1.66) 3.8%, uye hydroxyethyl cellulose i1.7%.Zvinogona kuonekwa kuti anti-enzyme kukwanisa kwehydroxypropyl methylcellulose yakasimba.Naizvozvo, iyo yakanakisa enzyme kuramba yehydroxypropyl methylcellulose, yakasanganiswa neyakanaka dispersibility, thickening uye film-forming properties, inowanzoshandiswa mumvura-emulsion coatings, nezvimwewo, uye kazhinji haidi kuwedzerwa kwekuchengetedza.Zvisinei, nokuda kwekuchengetwa kwenguva refu kwekugadzirisa kana kusvibiswa kunogona kuitika kwekunze kwenyika, zvidziviriro zvinogona kuwedzerwa sechidziviriro, uye sarudzo inogona kugadziriswa maererano nezvinodiwa zvekupedzisira zvekugadzirisa.Phenylmercuric acetate uye manganese fluorosilicate zvinochengetedza zvinobudirira, asi zvose zvine Toxicity, kutarisa kunofanira kubhadharwa kukushanda, uye chiyero chinowanzoita 1 ~ 5mg ye phenylmercuric acetate per litre yemhinduro.
7. Zvinhu zve hydroxypropyl methylcellulose firimu
Kuita kwehydroxypropyl methylcellulose firimu Hydroxypropyl methylcellulose ine yakanakisa kugadzira firimu, uye mhinduro yayo ine aqueous kana organic solvent solution inoputirwa pandiro yegirazi, uye inova isina ruvara uye yakajeka mushure mekuoma.Uye firimu rakaoma.Iine hunyoro hwakanaka hwekudzivisa uye inoramba yakasimba pakupisa kwepamusoro.Semuenzaniso, kuwedzera hygroscopic plasticizer inogona kuwedzera kureba kwayo uye kuchinjika.Kuti uvandudze kushanduka, mapurasitiki akadai se glycerin uye sorbitol ndiyo inonyanya kukodzera.Iyo general solution concentration ndeye 2% ~ 3%, uye huwandu hweplasticizer i10% ~ 20% ye cellulose ether.Kana zvinyorwa zve plasticizer zvakanyanyisa, shrinkage phenomenon ye colloid dehydration ichaitika pasi pemvura yakakwirira.Kusimba kwekusimba kwefirimu neplasticizer yakawedzerwa yakakura kudarika iyo isina plasticizer, uye inowedzera nekuwedzera kwehuwandu hwakawedzerwa.Kana iri hygroscopicity yefirimu, inowedzerawo nekuwedzera kwehuwandu hweplasticizer.
Nguva yekutumira: Oct-13-2022