Hydroxypropyl methyl cellulose HPMC bụ ụdị na-abụghị ionic cellulose agwakọta ether, nke dị iche na ionic methyl carboxymethyl cellulose weere ether, na ọ dịghị meghachi omume na arọ ọla.N'ihi nha dị iche iche nke ọdịnaya methylcellulose na hydroxypropyl dị na hydroxypropyl methylcellulose na viscosities dị iche iche, ọ ghọọla ụdị dị iche iche nke nwere ihe dị iche iche, dịka ọmụmaatụ, ọdịnaya methoxyl dị elu na ọdịnaya hydroxypropyl dị ala Ọrụ ya dị nso na nke methyl cellulose, na ụdị dị iche iche nwere obere metoxyl na ọdịnaya hydroxypropyl dị elu, arụmọrụ ya dị nso na nke hydroxypropyl methylcellulose.Otú ọ dị, n'ụdị dị iche iche, ọ bụ ezie na ọ bụ naanị obere hydroxypropyl otu ma ọ bụ obere methoxy dị n'ime ya, solubility na organic solvents ma ọ bụ flocculation okpomọkụ na aqueous ngwọta dị nnọọ iche.
1. Ihe solubility nke hydroxypropyl methylcellulose
① Solubility nke hydroxypropyl methyl cellulose na mmiri Hydroxypropyl methyl cellulose bụ n'ezie a methyl cellulose gbanwetụrụ site propylene oxide (methyl oxypropylene), n'ihi ya, ọ ka nwere otu ihe onwunwe dị ka methyl cellulose.Cellulose yiri nke ahụ na mmiri oyi na-adịghị ike na mmiri ọkụ.Otú ọ dị, n'ihi otu hydroxypropyl a gbanwere, okpomọkụ gelation ya na mmiri ọkụ dị elu karịa nke methyl cellulose.Dịka ọmụmaatụ, viscosity nke ngwọta mmiri nke hydroxypropyl methylcellulose nwere 2% methoxyl ọdịnaya DS=0.73 yana ọdịnaya hydroxypropyl MS=0.46 bụ 500mpa?s na 20°C.Okpomọkụ gel ya Ọ nwere ike iru nso 100 Celsius, ebe methylcellulose n'otu ọnọdụ ahụ dị naanị ihe dịka 55 Celsius.N'ihe banyere solubility ya na mmiri, a na-emeziwanye ya nke ọma.Dị ka ihe atụ, na pulverized hydroxypropyl methylcellulose (granular udi nke 0.2 ~ 0.5mm na 20 ° C na a viscosity nke 4% aqueous ngwọta ruo 2pa?s nwere ike iji na ụlọ okpomọkụ, ọ na-adị mfe soluble na mmiri na-enweghị jụrụ.
②The solubility nke hydroxypropyl methyl cellulose na organic solvents The solubility nke hydroxypropyl methyl cellulose na organic solvents dịkwa mma karịa nke methyl cellulose, na methyl cellulose kwesịrị inwe a ogo nke methoxyl nnọchi na ngwaahịa n'elu 2.1, na elu-viscosity hydroxypropyl methylcellulose nwere. hydroxypropyl MS = 1.5 ~ 1.8 na methoxy DS = 0.2 ~ 1.0, na ngụkọta nnọchi ogo n'elu 1.8 bụ soluble na anhydrous methanol na ethanol ngwọta ọkara, thermoplastic na mmiri-soluble.Ọ na-agbazekwa na chlorinated hydrocarbons dị ka dichloromethane na chloroform, yana na ihe mgbaze organic dị ka acetone, isopropanol na mmanya diacetone.Ya solubility na organic solvents dị mma karịa mmiri-soluble.
2. Ihe ndị na-emetụta viscosity nke hydroxypropyl methylcellulose
Ihe na-emetụta mmetụta nke hydroxypropyl methyl cellulose viscosity Nchọpụta viscosity ọkọlọtọ nke hydroxypropyl methyl cellulose, dị ka cellulose ethers ndị ọzọ, dabeere na 2% mmiri mmiri na 20 ° C.Viscosity nke otu ngwaahịa na-abawanye na mmụba nke itinye uche.Maka ngwaahịa ndị nwere nha molekụla dị iche iche n'otu ntinye uche, ngwaahịa ndị nwere ibu arọ molekul nwere nnukwu viscosity.Mmekọrịta ya na okpomọkụ yiri nke methyl cellulose.Mgbe okpomọkụ na-abawanye, viscosity na-amalite ibelata, ma mgbe ọ ruru ụfọdụ okpomọkụ, viscosity na-abawanye na mberede na gelation na-eme.Igwe ọkụ gel nke ngwaahịa viscosity dị ala dị elu.dị elu.Ebe gel ya abụghị naanị ihe jikọrọ ya na viscosity nke ether, kamakwa na nhazi nke methoxy na hydroxypropyl na ether na ngụkọta nke nnọchi.Ekwesiri ighota na hydroxypropyl methylcellulose bụkwa pseudoplastic na ngwọta ya kwụsiri ike na ụlọ okpomọkụ na-enweghị mmebi ọ bụla nke viscosity ma e wezụga ohere nke mmebi enzymatic.
3. Hydroxypropyl methylcellulose acid na alkali iguzogide
Hydroxypropyl methylcellulose acid na alkali eguzogide Hydroxypropyl methylcellulose bụ n'ozuzu ike na acid na alkali, na ọ dịghị emetụta na nso nke pH 2 ~ 12.Ọ nwere ike iguzogide ụfọdụ ọkụ acid.Dị ka formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, wdg Otú ọ dị, concentrated acid nwere mmetụta nke ibelata viscosity.Alkali dị ka soda caustic, caustic potash na mmiri lime enweghị mmetụta na ya, mana ọ nwere ike ịbawanye viscosity nke ngwọta ahụ ntakịrị, mgbe ahụ, a ga-enwe ihe ngosi nke nwayọọ nwayọọ n'ọdịnihu.
4. Ngwakọta nke hydroxypropyl methylcellulose
Enwere ike ịgwakọta ihe ngwọta nke Hydroxypropyl Methyl Cellulose Hydroxypropyl methyl cellulose na mmiri polymer compound ka ọ bụrụ otu na ngwọta nghọta na viscosity dị elu.Ogige ndị a polymer gụnyere polyethylene glycol, polyvinyl acetate, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl cellulose na methyl cellulose.Ogige polymer eke dị ka chịngọm arabic, chịngọm igurube, karaya chịngọm, wdg nwekwara ezigbo mixability na ngwọta ya.A pụkwara ịgwakọta Hydroxypropyl methylcellulose na mannitol ma ọ bụ sorbitol esters nke stearic acid ma ọ bụ palmitic acid, a pụkwara ịgwakọta ya na glycerin, sorbitol na mannitol.Enwere ike iji ogige ndị a dị ka hydroxypropyl methylcellulose.Plasticizer dabeere na cellulose.
5. Insolubility na mmiri solubility nke hydroxypropyl methylcellulose
Ethers cellulose na-adịghị edozi mmiri nke na-eme ka mmiri na-adịghị ike nke hydroxypropyl methylcellulose nwere ike jikọta ya na aldehydes, na ethers ndị a na-agbaze mmiri na-agbanye na ngwọta na-aghọ ihe na-adịghị edozi na mmiri.Aldehydes nke na-eme hydroxypropyl methylcellulose insoluble gụnyere formaldehyde, glyoxal, succinaldehyde, adipaldehyde, wdg Mgbe ị na-eji formaldehyde, a ga-akwụ ụgwọ nlebara anya pụrụ iche na pH uru nke ngwọta, n'ime nke glioxal na-eme ngwa ngwa.Ya mere, a na-ejikarị glycoxal eme ihe dị ka onye na-ejikọta ọnụ na mmepụta mmepụta ihe.Usoro onunu ogwu nke ụdị crosslinking a na ngwọta bụ 0.2% ~ 10% nke ether mass, ọkachamma 7% ~ 10%, na 3.3% ~ 6% bụ ihe kacha mma maka glycoxal.The izugbe ọgwụgwọ okpomọkụ bụ 0 ~ 30 ℃, na oge bụ 1 ~ 120min.A ghaghị ime mmeghachi omume na-ejikọta ya n'okpuru ọnọdụ acidic.N'ozuzu, inorganic acid siri ike ma ọ bụ organic carboxylic acid na-agbakwunye na ngwọta iji dozie pH nke ngwọta na ihe dịka 2 ~ 6, ọkacha mma n'etiti 4 ~ 6, mgbe ahụ, a na-agbakwunye aldehydes iji mee mmeghachi omume na-ejikọta ya..Acid ndị a na-eji gụnyere hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid ma ọ bụ citric acid, n'ime nke formic acid ma ọ bụ acetic acid dabara, na formic acid bụ nke kacha mma.A nwekwara ike ịgbakwunye acid na aldehyde n'otu oge iji mee ka ngwọta ahụ gafee n'ogo pH achọrọ.A na-ejikarị mmeghachi omume a eme ihe na usoro ọgwụgwọ ikpeazụ na usoro nkwadebe nke cellulose ethers.Mgbe ether cellulose na-esighi ike, ọ dị mma ịsacha ma mee ka mmiri dị ọcha na 20 ~ 25 ° C.Mgbe a na-eji ngwaahịa ahụ eme ihe, enwere ike ịgbakwunye ihe alkaline na ngwọta nke ngwaahịa ahụ iji dozie pH nke ngwọta na-edozi ahụ, ngwaahịa ahụ ga-agbaze na ngwọta ngwa ngwa.Usoro a na-adabakwa na ngwọta cellulose ether mere ka ọ bụrụ ihe nkiri na mgbe ahụ, a na-edozi ihe nkiri ahụ iji mee ka ọ bụrụ ihe nkiri na-adịghị edozi.
6. Hydroxypropyl methylcellulose na-eguzogide ọgwụ enzymes
Hydroxypropyl methylcellulose na-eguzogide ọgwụ enzymes.Na tiori, mkpụrụ ndụ cellulose, dị ka otu anhydroglucose nke ọ bụla, nwere otu nnọchi nke nwere njikọ siri ike, nke na-adịghị adị mfe nje site na microorganisms, mana n'ezie ngwaahịa emechara mgbe uru nnọchi karịa 1, a ga-emebi ya site na enzymes. nke pụtara na ogo ngbanwe nke otu ọ bụla na agbụ cellulose ezughị oke, na microorganisms nwere ike imebi n'akụkụ otu anhydroglucose na-edoghị anya iji mepụta shuga., nke a na-etinye obi dị ka nri maka microorganisms.Ya mere, ọ bụrụ na etherification ngbanwe nke cellulose na-abawanye, a na-akwalitekwa nguzogide enzymatic nke cellulose ether.A na-akọ na viscosity fọdụrụnụ nke hydroxypropyl methylcellulose (DS=1.9) bụ 13.2%, methylcellulose (DS=1.83) bụ 7.3%, na methylcellulose (DS=1.66) bụ 3.8%, na hydroxyethyl cellulose bụ 1.7%.Enwere ike ịhụ na ikike mgbochi enzyme nke hydroxypropyl methylcellulose siri ike.Ya mere, a na-ejikarị nguzogide enzyme hydroxypropyl methylcellulose dị mma, jikọtara ya na mgbasa ozi dị mma, nke na-emepụta ihe na ihe nkiri, na-ejikarị eme ihe na mkpuchi mmiri-emulsion, wdg, na n'ozuzu ọ dịghị achọ mgbakwunye nke ihe nchekwa.Otú ọ dị, maka nchekwa ogologo oge nke ngwọta ma ọ bụ mmetọ nwere ike ime n'èzí, a pụrụ ịgbakwunye ihe nchekwa dị ka ihe nchebe, na nhọrọ nwere ike ikpebi dịka ihe ikpeazụ chọrọ nke ngwọta ahụ.Phenylmercuric acetate na manganese fluorosilicate bụ ihe nchekwa dị irè, ma ha nwere ma Nsi, a ghaghị ịkwụ ụgwọ nlebara anya na ọrụ ahụ, na usoro ọgwụgwọ bụ 1 ~ 5mg nke phenylmercuric acetate kwa liter nke ngwọta.
7. Njirimara nke ihe nkiri hydroxypropyl methylcellulose
Arụmọrụ nke hydroxypropyl methylcellulose film Hydroxypropyl methylcellulose nwere magburu onwe film-akpụ Njirimara, na ya aqueous ngwọta ma ọ bụ organic ihe mgbaze na-kpuchie na a iko efere, na ọ na-aghọ enweghị color na uzo mgbe ihicha.Na ihe nkiri siri ike.Ọ nwere ezigbo nguzogide mmiri ma na-anọgidesi ike na oke okpomọkụ.Dịka ọmụmaatụ, ịgbakwunye plasticizer hygroscopic nwere ike ịkwalite elongation na mgbanwe ya.Iji meziwanye mgbanwe, plasticizers dị ka glycerin na sorbitol kacha adabara.Ntuzi ihe ngwọta n'ozuzu bụ 2% ~ 3%, na ego nke plasticizer bụ 10% ~ 20% nke cellulose ether.Ọ bụrụ na ọdịnaya nke plasticizer dị oke elu, ihe nhụsianya nke nkụnye mmiri colloid ga-eme n'okpuru oke iru mmiri.Ike ike nke ihe nkiri ahụ na plasticizer agbakwunyere dị ukwuu karịa nke na-enweghị plasticizer, ọ na-abawanye na mmụba nke ego agbakwunyere.N'ihe gbasara hygroscopicity nke ihe nkiri ahụ, ọ na-abawanye na ụba nke plasticizer.
Oge nzipu: Ọktoba 13-2022