IHydroxypropyl methyl cellulose HPMC luhlobo lwe-ether engeyiyo ionic cellulose exutywe ne-ether, eyahlukileyo kwi-ionic methyl carboxymethyl cellulose exutywe i-ether, kwaye ayisebenzi kunye neentsimbi ezinzima.Ngenxa yemilinganiselo eyahlukeneyo yomxholo we-methoxyl kunye nomxholo we-hydroxypropyl kwi-hydroxypropyl methylcellulose kunye ne-viscosities eyahlukeneyo, iye yaba yindidi ehlukeneyo eneempawu ezahlukeneyo, umzekelo, umxholo ophezulu we-methoxyl kunye nomxholo ophantsi we-hydroxypropyl Ukusebenza kwayo kusondele kuleyo ye-methyl cellulose, kwaye iintlobo ezinomxholo ophantsi we-methoxyl kunye nomxholo ophezulu we-hydroxypropyl, ukusebenza kwayo kusondele kwi-hydroxypropyl methylcellulose.Nangona kunjalo, kwiindidi ezahlukeneyo, nangona kuphela inani elincinci leqela le-hydroxypropyl okanye inani elincinci leqela le-methoxy liqulethwe, ukunyibilika kwi-solvents yezinto eziphilayo okanye ubushushu be-flocculation kwisisombululo samanzi sahluke kakhulu.
1. Ukunyibilika kwe-hydroxypropyl methylcellulose
①Ukunyibilika kwe-hydroxypropyl methyl cellulose emanzini I-Hydroxypropyl methyl cellulose eneneni yi-methyl cellulose elungiswe yi-propylene oxide (methyl oxypropylene), ngoko ke iseneempawu ezifanayo njenge-methyl cellulose.I-Cellulose iyafana nokunyibilika kwamanzi abandayo kunye nokunganyibiliki kwamanzi ashushu.Nangona kunjalo, ngenxa yeqela le-hydroxypropyl elungisiweyo, ubushushu bayo be-gelation emanzini ashushu buphezulu kakhulu kune-methyl cellulose.Umzekelo, i-viscosity yesisombululo se-aqueous ye-hydroxypropyl methylcellulose ene-2% ye-methoxyl content DS=0.73 kunye ne-hydroxypropyl content MS=0.46 yi-500 mpa?s kwi-20 ° C.Ubushushu bayo bejeli Inokufikelela kufutshane ne-100 ° C, ngelixa i-methylcellulose kubushushu obufanayo bumalunga ne-55 ° C kuphela.Ngokuphathelele ukunyibilika kwayo emanzini, nayo iphuculwe kakhulu.Umzekelo, i-pulverized hydroxypropyl methylcellulose (imilo yegranular ye-0.2 ~ 0.5mm kwi-20 ° C kunye ne-viscosity ye-4% yesisombululo samanzi ukuya kwi-2pa?
②I-solubility ye-hydroxypropyl methyl cellulose kwizinyibilikisi zendalo Ukunyibilika kwe-hydroxypropyl methyl cellulose kwizinyibiliki zendalo nako kubhetele kunaleyo ye-methyl cellulose, kwaye i-methyl cellulose ifuna ukuba neqondo lokuthatha indawo ye-methoxyl kwiiMveliso ezingaphezulu kwe-2.1, kunye ne-high-viscosity equlethe i-hydroxyprosellulose I-hydroxypropyl MS = 1.5 ~ 1.8 kunye ne-methoxy DS = 0.2 ~ 1.0, kunye ne-degree substitution degree ngaphezu kwe-1.8 iyanyibilika kwi-anhydrous methanol kunye ne-ethanol solutions medium, thermoplastic and water-soluble.Ikwanyibilika kwiihydrocarbon eziklorini ezifana ne-dichloromethane kunye ne-chloroform, nakwi-solvents eziphilayo ezifana ne-acetone, isopropanol kunye ne-diacetone alcohol.Ukunyibilika kwayo kwizinyibilikisi zendalo kubhetele kunokunyibilika emanzini.
2. Izinto ezichaphazela i-viscosity ye-hydroxypropyl methylcellulose
Izinto ezinempembelelo kwi-hydroxypropyl methyl cellulose viscosity Ukumiselwa kwe-viscosity esemgangathweni ye-hydroxypropyl methyl cellulose, njengezinye i-cellulose ethers, isekelwe kwi-2% yesisombululo se-aqueous kwi-20 °C.I-viscosity yemveliso efanayo iyanda ngokunyuka koxinzelelo.Kwiimveliso ezinobunzima obuhlukeneyo beemolekyuli kwinqanaba elifanayo, iimveliso ezinobunzima obukhulu be-molecular zine-viscosity ephezulu.Ubudlelwane bayo kunye nobushushu bufana ne-methyl cellulose.Xa izinga lokushisa linyuka, i-viscosity iqala ukuhla, kodwa xa ifikelela kwiqondo lokushisa elithile, i-viscosity iyanda ngokukhawuleza kwaye i-gelation iyenzeka.Ubushushu be-gel yeemveliso ezisezantsi ze-viscosity ziphezulu.iphezulu.I-gel point yayo ayihambelani kuphela ne-viscosity ye-ether, kodwa kunye nomlinganiselo wokubunjwa kwe-methoxy kunye ne-hydroxypropyl kwi-ether kunye neqondo elipheleleyo lokutshintshwa.Kufuneka kuqatshelwe ukuba i-hydroxypropyl methylcellulose nayo i-pseudoplastic kwaye isisombululo sayo sizinzile kwiqondo lokushisa ngaphandle kokuthotywa kwe-viscosity ngaphandle kokuba kunokwenzeka ukuchithwa kwe-enzymatic.
3. I-Hydroxypropyl methylcellulose acid kunye nokumelana ne-alkali
I-Hydroxypropyl methylcellulose acid kunye nokumelana ne-alkali I-Hydroxypropyl methylcellulose ngokuqhelekileyo izinzile kwi-asidi kunye ne-alkali, kwaye ayichaphazeleki kuluhlu lwe-pH 2 ~ 12.Inokumelana nomlinganiselo othile we-asidi ekhanyayo.Ezifana ne-formic acid, i-acetic acid, i-citric acid, i-succinic acid, i-phosphoric acid, i-boric acid, njl. Nangona kunjalo, i-asidi egxininisiweyo inefuthe lokunciphisa i-viscosity.I-alkali efana ne-caustic soda, i-potash ye-caustic kunye namanzi e-lime ayinayo impembelelo kuyo, kodwa inokunyusa kancinane i-viscosity yesisombululo, kwaye kuya kubakho isiganeko sokuhla kancinci kwixesha elizayo.
4. Ukuxutywa kwe-hydroxypropyl methylcellulose
I-Miscibility ye-Hydroxypropyl Methyl Cellulose Isisombululo se-Hydroxypropyl methyl cellulose sinokuxutywa kunye nekhompawundi ye-polymer enyibilikayo yamanzi ukuze ibe yinto efanayo kunye nesisombululo esicacileyo kunye ne-viscosity ephezulu.Ezi zixhobo ze-polymer ziquka i-polyethylene glycol, i-polyvinyl acetate, i-polysiloxane, i-polymethyl vinyl siloxane, i-hydroxyethyl cellulose kunye ne-methyl cellulose.Iikhompawundi zepolymer zendalo ezifana nentlaka ye-arabic, intshungama yembotyi yeenkumbi, i-karaya gum, njl njl.IHydroxypropyl methylcellulose ingaxutywa nemannitol okanye i-sorbitol esters ye-stearic acid okanye i-palmitic acid, kwaye ingaxutywa ne-glycerin, i-sorbitol kunye ne-mannitol.Ezi khompawundi zingasetyenziswa njenge hydroxypropyl methylcellulose.Iplastiki esekelwe kwi-cellulose.
5. Ukungabi namanzi kunye ne-solubility yamanzi ye-hydroxypropyl methylcellulose
I-ethers ye-cellulose e-soluble yamanzi e-insolubilized ye-hydroxypropyl methylcellulose inokuxutywa phezulu kunye ne-aldehydes, kwaye ezi zi-ethers ezixutywe ngamanzi zixutywe kwisisombululo kwaye zingabi namanzi.I-aldehydes eyenza i-hydroxypropyl methylcellulose i-insoluble iquka i-formaldehyde, i-glyoxal, i-succinaldehyde, i-adipaldehyde, njl. Xa usebenzisa i-formaldehyde, ingqalelo ekhethekileyo kufuneka ihlawulwe kwixabiso le-pH yesisombululo, phakathi kwayo i-glyoxal isabela ngokukhawuleza.Ke ngoko, i-glyoxal isetyenziswa ngokuqhelekileyo njenge-agent edibanisayo kwimveliso yamashishini.I-dosage yolu hlobo lwe-agent agent kwisisombululo ngu-0.2% ~ 10% ye-ether mass, ngokukhethekileyo i-7% ~ 10%, kunye ne-3.3% ~ 6% yeyona nto ifanelekileyo kwi-glyoxal.Ubushushu bonyango jikelele ngu-0 ~ 30℃, kwaye ixesha yi-1 ~ 120min.Ukusabela kwe-cross-linking kufuneka kuqhutywe phantsi kweemeko ze-acidic.Ngokubanzi, i-asidi elomeleleyo ye-inorganic okanye i-organic carboxylic acid yongezwa kwisisombululo ukulungisa i-pH yesisombululo malunga ne-2 ~ 6, ngokukodwa phakathi kwe-4 ~ 6, kwaye ke i-aldehydes yongezwa ukwenza ukusabela kokudibanisa..Iiasidi ezisetyenzisiweyo ziquka i-hydrochloric acid, i-sulfuric acid, i-phosphoric acid, i-asidi ye-fomic, i-acetic acid, i-hydroxyacetic acid, i-succinic acid okanye i-citric acid, phakathi kwayo i-formic acid okanye i-acetic acid ifanelekile, kwaye i-asidi ye-formic yeyona ifanelekileyo.I-asidi kunye ne-aldehyde nayo inokongezwa ngaxeshanye ukuvumela isisombululo ukunqumla kwi-pH efunwayo.Le mpendulo idla ngokusetyenziswa kwinkqubo yokugqibela yokonyango kwinkqubo yokulungiselela i-cellulose ethers.Emva kokuba i-ether ye-cellulose i-insolubilized, kukulungele ukuhlamba kunye nokucoca ngamanzi kwi-20 ~ 25 ° C.Xa imveliso isetyenziswa, i-alkaline substance inokongezwa kwisisombululo semveliso ukulungisa i-pH yesisombululo ukuba ibe yi-alkaline, kwaye imveliso iya kuchithwa kwisisombululo ngokukhawuleza.Le ndlela iphinda isetyenziswe kwisisombululo se-cellulose ether esenziwe kwifilimu kwaye emva koko ifilimu icutshungulwa ukuze iyenze ifilimu engenakunyibilika.
6. I-Hydroxypropyl methylcellulose iyaxhathisa kwi-enzymes
IHydroxypropyl methylcellulose iyaxhathisa kwii-enzymes.Kwithiyori, i-cellulose derivatives, njengeqela ngalinye le-anhydroglucose, ineqela elibambeleyo elibambene ngokuqinileyo, elingelula ukusuleleka yi-microorganisms, kodwa ngokwenene imveliso egqityiweyo Xa ixabiso lokutshintshwa lidlula i-1, liya kuthotywa kwakhona yi-enzymes, oku kuthetha ukuba iqondo lokutshintshwa kweqela ngalinye kwikhonkco leselulosi alifani ngokwaneleyo, kwaye ii-microorganisms zinokukhukuliseka kufuphi namaqela angatshintshiyo e-anhydroglucose ukwenza iiswekile., ezifunxwa njengezondlo ze-microorganisms.Ke ngoko, ukuba iqondo lokuthatha indawo ye-etherification yeselulosi liyenyuka, ukuxhathisa kukhukuliseko lwe-enzymatic ye-cellulose ether kuyaphuculwa.Kuxelwe ukuba i-viscosity eseleyo ye-hydroxypropyl methylcellulose (DS = 1.9) yi-13.2%, i-methylcellulose (DS = 1.83) yi-7.3%, kunye ne-methylcellulose (DS = 1.66) yi-3.8%, kunye ne-hydroxyethyl cellulose yi-1.7%.Ingabonwa ukuba amandla okulwa ne-enzyme ye-hydroxypropyl methylcellulose yomelele.Ngoko ke, ukuchasana kwe-enzyme egqwesileyo ye-hydroxypropyl methylcellulose, idibaniswe ne-dispersibility yayo efanelekileyo, i-thickening kunye ne-film-forming properties, isetyenziswa ngokubanzi kwiingubo ze-emulsion zamanzi, njl., kwaye ngokuqhelekileyo ayifuni ukongezwa kwe-preservatives.Nangona kunjalo, ukugcinwa kwexesha elide lesisombululo okanye ukungcoliseka okunokwenzeka kwehlabathi langaphandle, izilondolozo zinokongezwa njengento yokukhusela, kwaye ukhetho lunokumiselwa ngokweemfuno zokugqibela zesisombululo.I-Phenylmercuric acetate kunye ne-manganese fluorosilicate zizigcini ezisebenzayo, kodwa zine-Toxicity zombini, ingqalelo kufuneka ihlawulwe ekusebenzeni, kwaye i-dosage ngokubanzi yi-1 ~ 5mg ye-acetate ye-phenylmercuric nganye ilitha yesisombululo.
7. Iipropati zefilimu ye-hydroxypropyl methylcellulose
Ukusebenza kwefilimu ye-hydroxypropyl methylcellulose i-Hydroxypropyl methylcellulose ineepropati ezintle kakhulu zokwenza ifilimu, kwaye isisombululo sayo samanzi okanye isisombululo se-solvent se-organic sifakwe kwi-plate yeglasi, kwaye ingabi mbala kwaye ibonakale emva kokumisa.Kwaye ifilimu enzima.Inokumelana nokufuma okuhle kwaye ihlala yomelele kumaqondo obushushu aphezulu.Ngokomzekelo, ukongeza iplastiki ye-hygroscopic inokwandisa ubude bayo kunye nokuguquguquka.Ukuphucula ukuguquguquka, iiplastiki ezifana ne-glycerin kunye ne-sorbitol zizona zifanelekileyo.I-concentration yesisombululo ngokubanzi yi-2% ~ 3%, kwaye inani le-plasticizer yi-10% ~ 20% ye-cellulose ether.Ukuba umxholo we-plasticizer uphezulu kakhulu, i-shrinkage phenomenon ye-colloid dehydration iya kwenzeka phantsi komswakama ophezulu.Amandla obunzima befilimu ene-plasticizer eyongeziweyo inkulu kakhulu kunokuba ngaphandle kweplastiki, kwaye iyanda ngokunyuka kwexabiso elongezelelweyo.Ngokuphathelele i-hygroscopicity yefilimu, iphinda inyuke ngokunyuka kwexabiso leplastiki.
Ixesha lokuposa: Oct-13-2022