Hydroxypropylmethylcellulose (HPMC) ikamu rinoshandiswa zvakasiyana-siyana rinoshandiswa mumaindasitiri akasiyana siyana, kusanganisira zvikamu zvemishonga uye zvekudya zvekuwedzera.Kuvapo kwayo muzvishongedzo kunogona kuverengerwa kune akati wandei anobatsira zvivakwa, zvichiita kuti ive chinhu chinokwezva chevagadziri.
1. Nhanganyaya yeHydroxypropyl Methylcellulose (HPMC):
Hydroxypropylmethylcellulose is semi-synthetic polymer inotorwa kubva ku cellulose, yakasikwa polymer inowanikwa muchirimwa sero madziro.Iyo synthesis inosanganisira kurapa cellulose nepropylene oxide uye methyl chloride, zvichikonzera makomisheni ane zvivakwa zvakasimudzirwa zvichienzaniswa nemubereki wavo cellulose.HPMC inozivikanwa nekunyungudika kwemvura, kugona kugadzira firimu, uye biocompatibility.
2. Chimiro chemakemikari uye zvivakwa:
HPMC ine glucose inodzokorora mayunitsi ane hydroxypropyl uye methoxy substituents.Iyo dhigirii yekutsiva (DS) inoreva avhareji yenhamba yezvinotsiva paglucose unit uye inogona kusiyana, inokanganisa zvimiro zveHPMC.Iro hydroxypropyl boka rinobatsira mukunyungudika kwemvura, nepo methoxy boka rinopa firimu-kugadzira zvinhu.
3. Mabasa ekuwedzera:
A. Binders uye disintegrants:
HPMC inoshanda sebhainda uye inobatsira kusunga zvinongedzo mumapiritsi ekuwedzera pamwechete.Kuparara kwayo kunobatsira kuparara kwehwendefa, zvichiita kuti mapiritsi aputsika kuita twunhu tudiki kuti akwanise kunyura mukugaya.
b.Sustained release:
Kudzorwa kuburitswa kwezvinhu zvinoshanda kwakakosha kune mamwe ekuwedzera.HPMC inoshandiswa kugadzira matrix inodzora kuburitswa kwezvinhu, zvichikonzera kuchengetedzwa kwakasimba uye kwakadzora kuendeswa kwezvinovaka muviri.
C. Capsule coating:
Pamusoro pekushandisa piritsi, HPMC inoshandiswawo sechinhu chekuputira chekuwedzera macapsules.Iyo firimu-inogadzira zvimiro zveHPMC inofambisa kugadzirwa kwemakapisi ari nyore kumedza uye kuparara zvakanaka mudumbu rekudya.
d.Stabilizers uye thickeners:
HPMC inoshanda seyakagadzika mukugadzirwa kwemvura kudzivirira zvikamu kubva pakuparadzana.Kugona kwayo kukora zvigadziriso zvinobatsira mukuvandudza kwe viscous syrups kana kumiswa mune yemvura yekuwedzera.
e.Vegetarian uye Vegan Recipes:
HPMC inotorwa kubva muzvirimwa uye yakakodzera kune vegetarian uye vegan supplement formulations.Izvi zvinoenderana nekukura kuri kudiwa kwevatengi kune dzimwe nzira dzekudyara uye kufunga kwehunhu mukuvandudza chigadzirwa.
4. Regulatory kufunga:
Hydroxypropyl methylcellulose inowanzo zivikanwa seyakachengeteka (GRAS) nemasangano anodzora akadai seUS Food and Drug Administration (FDA) uye European Food Safety Authority (EFSA).Kushandiswa kwayo kwakapararira mumishonga uye zvekuwedzera zvinotsigirwa nehuwandu hwekuchengetedza kwayo.
5. Matambudziko nekufunga:
A. Sensitivity kune zvakatipoteredza mamiriro:
Kuita kweHPMC kunogona kukanganiswa nemamiriro ekunze akadai sehunyoro.Vagadziri vanofanira kunyatsotarisa mamiriro ekuchengetedza kuchengetedza kugadzikana kwekuwedzera uye kushanda.
b.Kudyidzana nezvimwe zvinhu:
HPMC inofanirwa kuongororwa kuti inoenderana nezvimwe zvinongedzo mukugadzira kudzivirira kusangana kungangokanganisa kunaka kwechigadzirwa.
6. Mhedziso:
Hydroxypropyl methylcellulose inoita basa rakakosha mukudya kwekuwedzera maumbirwo, kubatsira kuvandudza kugadzikana, bioavailability uye nyore kushandisa kwezvakasiyana zvigadzirwa zvinovaka muviri.Zvimiro zvaro zvakasiyana-siyana zvinoita kuti ive sarudzo yepamusoro kune vanogadzira vanotarisa kuti vawedzere kuita uye kukwezva kwezvekuwedzera kwavo.Sezvo zvido zvevatengi zvachinja, HPMC ingangoramba iri chinhu chakakosha mukusimudzira kuvandudza uye kunoshanda kwekudya kwekuwedzera maumbirwo.
Nguva yekutumira: Zvita-26-2023