Hydroxypropylmethylcellulose (HPMC) ni uruganda rutandukanye rukoreshwa mu nganda zinyuranye, harimo imiti n’ibiryo byongera ibiryo.Kubaho kwinyongera birashobora kwitirirwa kubintu byinshi byingirakamaro, bigatuma biba ibintu byiza kubashinzwe gukora.
1. Intangiriro kuri Hydroxypropyl Methylcellulose (HPMC):
Hydroxypropylmethylcellulose ni igice cya sintetike ya polymer ikomoka kuri selile, polymer karemano iboneka murukuta rw'utugingo ngengabuzima.Synthesis ikubiyemo kuvura selile hamwe na okiside ya propylene na methyl chloride, bikavamo ibice bifite imitungo yiyongereye ugereranije na selile yababyeyi.HPMC izwiho gukemura amazi, ubushobozi bwo gukora firime, hamwe na biocompatibilité.
2. Imiterere yimiti nimiterere:
HPMC igizwe na glucose isubiramo ibice hamwe na hydroxypropyl hamwe na metxy ya insimburangingo.Urwego rwo gusimbuza (DS) bivuga impuzandengo y'ibisimburwa kuri glucose kandi birashobora gutandukana, bigira ingaruka kumiterere ya HPMC.Itsinda rya hydroxypropyl rigira uruhare mu gukemura amazi, mugihe itsinda ryimikorere ritanga ibintu byerekana firime.
3. Imikorere yinyongera:
A. Guhuza no gutandukana:
HPMC ikora nka binder kandi ifasha guhuza ibiyigize mubinini byongeweho hamwe.Ibikoresho byayo bisenya bifasha ibinini bisenyuka, byemeza ko ibinini bigabanyijemo uduce duto kugirango twinjire neza muri sisitemu yumubiri.
b.Kurekurwa kuramba:
Kugenzura kurekura ibintu bifatika nibyingenzi kubwinyongera.HPMC ikoreshwa mugukora matrix igenzura igipimo cyo kurekura ibintu, bigatuma habaho intungamubiri zirambye kandi zigenzurwa.
C. Igipfundikizo cya capsule:
Usibye ibinini bya tablet, HPMC nayo ikoreshwa nkibikoresho byo gutwikira capsules.Imiterere ya firime ya HPMC yorohereza iterambere rya capsules byoroshye kumira no gusenyuka neza mubice byigifu.
d.Stabilisateur hamwe niyongera:
HPMC ikora nka stabilisateur mumashanyarazi kugirango ibuze ibice gutandukana.Ubushobozi bwayo bwo kubyibuha bifasha mugutezimbere sirupe viscous cyangwa guhagarikwa mumazi yinyongera.
e.Ibikomoka ku bimera n'ibikomoka ku bimera:
HPMC ikomoka ku bimera kandi ikwiranye n’ibikomoka ku bimera n’ibikomoka ku bimera.Ibi bijyanye no kwiyongera kw'abaguzi bakeneye ubundi buryo bushingiye ku bimera no gutekereza ku myitwarire myiza mu iterambere ry'ibicuruzwa.
4. Ibitekerezo bigenga:
Hydroxypropyl methylcellulose isanzwe izwi nk’umutekano (GRAS) n’inzego zishinzwe kugenzura nk’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA) n’ikigo cy’uburayi gishinzwe umutekano w’ibiribwa (EFSA).Gukoresha kwinshi mumiti ninyongera bishyigikirwa numwirondoro wacyo.
5. Ibibazo n'ibitekerezo:
A. Kumva neza ibidukikije:
Imikorere ya HPMC irashobora guterwa nibintu bidukikije nkubushuhe.Ababikora bagomba gutekereza neza kububiko kugirango bakomeze gutuza no gukora neza.
b.Imikoranire nibindi bikoresho:
HPMC igomba gusuzumwa kugirango ihuze nibindi bikoresho muburyo bwo kuyitegura kugirango hirindwe imikoranire ishobora kugira ingaruka kubicuruzwa muri rusange.
6. Umwanzuro:
Hydroxypropyl methylcellulose igira uruhare runini mugutegura indyo yuzuye, ifasha kuzamura ituze, bioavailability no koroshya gukoresha ibicuruzwa bitandukanye byintungamubiri.Imiterere yimikorere myinshi ituma ihitamo ryambere kubashinzwe kureba bashaka kuzamura imikorere nubujurire bwinyongera zabo.Mugihe ibyifuzo byabaguzi bihinduka, HPMC irashobora gukomeza kuba ingenzi mugutezimbere ibyokurya bishya kandi byiza.
Igihe cyo kohereza: Ukuboza-26-2023