Hydroxypropylmethylcellulose (HPMC) bụ ngwa ngwa eji eme ihe n'ụdị ọrụ dị iche iche, gụnyere ngalaba mgbakwunye ọgwụ na nri.Ọnụnọ ya na mgbakwunye nwere ike ịpụta na ọtụtụ ihe bara uru, na-eme ka ọ bụrụ ihe na-adọrọ adọrọ maka ndị na-emepụta ihe.
1. Okwu Mmalite nke Hydroxypropyl Methylcellulose (HPMC):
Hydroxypropylmethylcellulose bụ polymer synthetic ọkara nke sitere na cellulose, polymer eke dị na mgbidi cell osisi.Ngwakọta ahụ na-agụnye ịgwọ cellulose na propylene oxide na methyl chloride, na-eme ka ogige nwere ihe ndị na-emewanyewanyewanye ma e jiri ya tụnyere nne na nna ha cellulose.A maara HPMC maka mmiri solubility ya, ike imepụta ihe nkiri, yana ihe ndị dị ndụ.
2. Chemical Ọdịdị na Njirimara:
HPMC nwere nkeji na-emegharị glucose nwere hydroxypropyl na methoxy nnọchi.Ogo ngbanwe (DS) na-ezo aka na nkezi ọnụ ọgụgụ nke nnọchi n'otu glucose ma nwee ike ịdị iche, na-emetụta njirimara nke HPMC.Otu hydroxypropyl na-enye aka na mmiri solubility, ebe otu methoxy na-enye ihe ndị na-emepụta ihe nkiri.
3. Ọrụ nke mgbakwunye:
A. Ihe nkedo na nkesa:
HPMC na-arụ ọrụ dị ka ihe nkedo ma na-enyere aka jikọta ihe ndị dị na mbadamba mbadamba ọnụ.Njirimara ya na-agbasasị na-enyere aka mgbasa mbadamba nkume, na-eme ka mbadamba nkume na-akụda n'ime obere irighiri ihe maka mmịnye kacha mma na sistem nri nri.
b.Ntọhapụ na-adịgide adịgide:
Ntọhapụ a na-achịkwa nke ihe ndị na-arụ ọrụ dị mkpa maka ụfọdụ mgbakwunye.A na-eji HPMC mepụta matriks nke na-achịkwa ọnụego ntọhapụ nke ihe, na-ebute nnyefe nke nri na-akwado ma na-achịkwa karịa.
C. Capsule mkpuchi:
Na mgbakwunye na ngwa mbadamba, a na-ejikwa HPMC dịka ihe mkpuchi maka capsules mgbakwunye.Ihe na-emepụta ihe nkiri nke HPMC na-eme ka mmepe nke capsules dị mfe ilo ma gbarie nke ọma na tract digestive.
d.Stabilizers na thickeners:
HPMC na-arụ ọrụ dị ka stabilizer na mmiri mmiri formulations iji gbochie components si ikewa.Ikike ya ịgbatị ihe ngwọta na-enyere aka na mmepe nke sirop viscous ma ọ bụ nkwusioru na mgbakwunye mmiri mmiri.
e.Nri nri onye anaghị eri anụ na anụ anaghị eri anụ:
HPMC sitere na osisi ma dabara adaba maka usoro mgbakwunye anaghị eri anụ na anụ anaghị eri anụ.Nke a kwekọrọ n'ọchịchọ ndị na-azụ ahịa na-arị elu maka ihe ndị ọzọ dabere na ihe ọkụkụ na echiche ziri ezi na mmepe ngwaahịa.
4. Ntụle usoro iwu:
A na-amatakarị Hydroxypropyl methylcellulose dị ka nchekwa (GRAS) site n'aka ụlọ ọrụ nhazi dịka US Food and Drug Administration (FDA) na European Food Safety Authority (EFSA).A na-akwado ojiji ya zuru ebe niile na ọgwụ na mgbakwunye site na profaịlụ nchekwa ya.
5. Ihe ịma aka na echiche:
A. Mmetụta na ọnọdụ gburugburu ebe obibi:
Ihe gburugburu ebe obibi dị ka iru mmiri nwere ike imetụta arụmọrụ HPMC.Ndị na-emepụta ihe ga-eji nlezianya tụlee ọnọdụ nchekwa iji kwado nkwụsi ike na ịdị irè nke mgbakwunye.
b.Mmekọrịta na ihe ndị ọzọ:
A ga-enyocharịrị HPMC maka ndakọrịta na ihe ndị ọzọ dị na nhazi ahụ iji zere mmekọrịta ndị nwere ike imetụta ogo ngwaahịa n'ozuzu ya.
6. Nkwubi okwu:
Hydroxypropyl methylcellulose na-arụ ọrụ dị mkpa na nhazi mgbakwunye nri, na-enyere aka melite nkwụsi ike, bioavailability na ịdị mfe nke oriri nke ngwaahịa nri dị iche iche.Njirimara multifunctional ya na-eme ka ọ bụrụ nhọrọ kachasị elu maka ndị na-emepụta ihe na-achọ ịkwalite arụmọrụ na mkpesa nke mgbakwunye ha.Ka mmasị ndị ahịa na-agbanwe, HPMC ga-aga n'ihu na-abụ isi ihe na mmepe nke usoro mgbakwunye nri ọhụrụ na nke dị irè.
Oge nzipu: Dec-26-2023