IHydroxypropyl Methylcellulose (HPMC) iyi-polymer eguquguqukayo enezinhlobonhlobo zokusetshenziswa kwemithi, izimonyo, ukudla, nezinye izimboni.Esinye sezici zayo eziphawulekayo izici zayo zokunamathisela i-mucoadhesive, eziyenza ibe yigugu ezinhlelweni zokulethwa kwezidakamizwa eziqondise indawo engaphezulu ye-mucosal.Ukuqonda okuphelele kwezakhiwo ze-HPMC ze-mucoadhesive kubalulekile ukuze kusetshenziswe ngokugcwele ekwenziweni kwemithi ukuze kutholakale imiphumela yokwelapha ethuthukisiwe.
1. Isingeniso:
IHydroxypropyl Methylcellulose (HPMC) iwumphumela wokwenziwa kwe-cellulose, esetshenziswa kabanzi ekwenziweni kwemithi ngenxa yokuhambisana kwayo ne-biocompatibility, ukungabi nobuthi, kanye nezakhiwo ezimangalisayo ze-physicochemical.Phakathi kwezicelo zayo eziningi, izakhiwo ze-HPMC zokunamathisela mucoadhesive zithole ukunakwa okubalulekile emkhakheni wezinhlelo zokulethwa kwezidakamizwa.I-Mucoadhesion isho ikhono lezinto ezithile ukunamathela ezindaweni ezingaphansi kwama-mucosal, ukwandisa isikhathi sokuhlala kwazo futhi kuthuthukise ukumuncwa kwezidakamizwa.Imvelo ye-HPMC ye-mucoadhesive iyenza ibe ikhandidethi elithembisayo lokuklama amasistimu okulethwa kwezidakamizwa aqondise izicubu ze-mucosal ezifana nomgudu wamathumbu, i-ocular surface, kanye ne-buccal cavity.Leli phepha lihlose ukuhlolisisa izakhiwo ze-mucoadhesive ze-HPMC, ukucacisa indlela yokusebenza kwayo, izici ezithonya ukunamathela kwe-mucoadhesion, izindlela zokuhlola, kanye nokusetshenziswa okuhlukahlukene ekwakhiweni kwemithi.
2. Indlela yokuhlanganisa i-Mucoadhesion:
Izakhiwo zokunamathisela i-mucoadhesive ye-HPMC zisuka esakhiweni sayo esiyingqayizivele samangqamuzana nokusebenzelana nezindawo ezimafinyila.I-HPMC iqukethe amaqembu e-hydrophilic hydroxyl, ayenza ikwazi ukwenza amabhondi e-hydrogen nama-glycoprotein akhona kulwelwesi lwe-mucosal.Lokhu kusebenzisana kwama-intermolecular kusiza ukusungulwa kwesibopho esingokomzimba phakathi kwe-HPMC kanye ne-mucosal surface.Ukwengeza, amaketanga e-polymer e-HPMC angabambana namaketanga e-mucin, athuthukise ukunamathela.Ukusebenzisana kwe-electrostatic phakathi kwama-mucins ane-negative kanye namaqembu asebenzayo afakwe kahle ku-HPMC, njengamaqembu e-quaternary ammonium, nakho kunomthelela ekubambeni kwe-mucoadhesion.Sekukonke, indlela ye-mucoadhesion ihilela ukusebenzisana okuyinkimbinkimbi kwe-hydrogen bonding, entanglement, kanye nokusebenzisana kwe-electrostatic phakathi kwe-HPMC kanye nezindawo zomucosal.
3. Izinto Ezithinta I-Mucoadhesion:
Kunezici ezimbalwa ezithonya izakhiwo ze-mucoadhesive ze-HPMC, ngaleyo ndlela zibe nomthelela ekusebenzeni kwayo ezinhlelweni zokulethwa kwezidakamizwa.Lezi zici zifaka isisindo samangqamuzana e-HPMC, ukugxila kwe-polymer ekwakhekeni, izinga lokushintshwa (DS), kanye ne-pH yendawo ezungezile.Ngokuvamile, isisindo esiphezulu samangqamuzana i-HPMC ibonisa amandla amakhulu okunamathela kwe-mucoadhesive ngenxa yokwanda kokubosheka kweketango nama-mucins.Ngokufanayo, ukuhlushwa okuphelele kwe-HPMC kubalulekile ekuzuzeni ukunamathela okwanele kwe-mucoadhesion, njengoba ukugxila okuphezulu ngokweqile kungase kuholele ekwakhekeni kwejeli, kuvimbe ukunamathela.Izinga lokushintshwa kwe-HPMC nalo lidlala indima ebalulekile, nge-DS ephezulu ethuthukisa izakhiwo zokunamathela ngokwandisa inani lamaqembu e-hydroxyl atholakalayo ukuze kusetshenziswe.Ngaphezu kwalokho, i-pH yendawo ye-mucosal ithonya ukunamathela kwe-mucoadhesion, njengoba ingathinta isimo se-ionization samaqembu asebenzayo ku-HPMC, ngaleyo ndlela iguqule ukusebenzisana kwe-electrostatic ne-mucins.
4. Izindlela Zokuhlola:
Kusetshenziswa izindlela ezimbalwa ukuhlola izakhiwo ze-mucoadhesive ze-HPMC ekwakhekeni kwemithi.Lokhu kufaka phakathi izilinganiso zamandla aqinile, izifundo ze-rheological, i-ex vivo kanye ne-vivo mucoadhesion assays, nezindlela zokucabanga ezifana ne-atomic force microscopy (AFM) kanye ne-scan electron microscopy (SEM).Izilinganiso zamandla aqinile zibandakanya ukubeka ijeli ye-polymer-mucin kumandla emishini kanye nokulinganisa amandla adingekayo ukuze kuhlanganiswe, kunikeze imininingwane yamandla okunamathela kwe-mucoadhesive.Izifundo ze-Rheological zihlola i-viscosity kanye nezakhiwo zokunamathisela zokwakheka kwe-HPMC ngaphansi kwezimo ezahlukahlukene, zisiza ekwenzeni kahle kwamapharamitha wokwakheka.I-Ex vivo kanye nokuhlolwa kwe-mucoadhesion ye-vivo kuhilela ukusetshenziswa kokwakheka kwe-HPMC endaweni engaphezulu ye-mucosal elandelwa ukulinganisa kokunamathela kusetshenziswa amasu afana nokuhlaziya ukuthungwa noma ukuhlolwa kwe-histological.Izindlela zokucabanga ezifana ne-AFM ne-SEM zinikeza ukuqinisekiswa okubonakalayo kokunamathela kwe-mucoadhesion ngokuveza i-morphology yokusebenzisana kwe-polymer-mucin ezingeni le-nanoscale.
5. Izicelo Ezinhlelweni Zokulethwa Kwezidakamizwa:
Izakhiwo ze-HPMC ezinamathelayo zithola izinhlelo zokusebenza ezihlukahlukene ezinhlelweni zokulethwa kwezidakamizwa, okuvumela ukukhululwa okuhlosiwe nokuqhubekayo kwama-ejenti okwelapha.Ekulethweni kwezidakamizwa ngomlomo, ukwakheka kwe-mucoadhesive okusekelwe ku-HPMC kungabambelela ku-mucosa yamathumbu, kwandise isikhathi sokuhlala kwezidakamizwa futhi kuthuthukise ukumuncwa.Amasistimu okulethwa kwezidakamizwa nge-Buccal nezilimi ezingaphansi asebenzisa i-HPMC ukukhuthaza ukunamathela endaweni engaphezulu ye-oral mucosal, kube lula ukulethwa kwezidakamizwa okuhlelekile noma kwendawo.Ukwakheka kwe-Ophthalmic okuqukethe i-HPMC kuthuthukisa ukugcinwa kwezidakamizwa ze-ocular ngokunamathela ku-epithelium ye-cornea ne-conjunctival, ukuthuthukisa ukusebenza kahle kokwelashwa kwe-topical.Ngaphezu kwalokho, izinhlelo zokulethwa kwezidakamizwa zesitho sangasese sowesifazane zisebenzisa amajeli e-HPMC anamathelayo ukuze anikeze ukukhululwa okuqhubekayo kwezivimbela-nzalo noma ama-ejenti alwa namagciwane, anikeza umzila ongahlaseli wokulawulwa kwezidakamizwa.
IHydroxypropyl Methylcellulose (HPMC) ikhombisa izinto ezimangalisayo zokunamathisela i-mucoadhesive, iyenze ibe yingxenye ebalulekile ekwakhiweni kwemithi okuhlukahlukene.Ikhono layo lokunamathela endaweni engaphandle kwe-mucosal lelula isikhathi sokuhlala kwezidakamizwa, lithuthukisa ukumuncwa, futhi lenze kube lula ukulethwa kwezidakamizwa okuhlosiwe.Ukuqonda indlela ye-mucoadhesion, izici ezithonya ukunamathela, izindlela zokuhlola, kanye nezicelo ezinhlelweni zokulethwa kwezidakamizwa kubalulekile ukuze kusetshenziswe amandla aphelele e-HPMC ekwakhekeni kwemithi.Ucwaningo olwengeziwe kanye nokwenza kahle kwezinhlelo ze-mucoadhesive ezisekelwe ku-HPMC zinesithembiso sokuthuthukisa imiphumela yokwelapha kanye nokuthobela isiguli emkhakheni wokulethwa kwezidakamizwa.
Isikhathi sokuthumela: Apr-03-2024