Ese HPMC ni mucoadhesive

Hydroxypropyl Methylcellulose (HPMC) ni polymer itandukanye kandi ifite uburyo bwinshi bwo gukoresha imiti, amavuta yo kwisiga, ibiryo, nizindi nganda.Kimwe mu bintu biranga ibintu ni imiterere ya mucoadhesive, ituma iba ingirakamaro muri sisitemu yo gutanga ibiyobyabwenge byibasira ururenda.Gusobanukirwa neza imiterere ya mucoadhesive ya HPMC ningirakamaro mugutezimbere imikoreshereze yimiti ya farumasi kugirango umusaruro ushimishije.

1. Intangiriro:

Hydroxypropyl Methylcellulose (HPMC) ni kimwe cya kabiri cya sintetike ikomoka kuri selile, ikoreshwa cyane mu miti y’imiti bitewe na biocompatibilité, idafite uburozi, hamwe n’imiterere idasanzwe ya fiziki.Mubikorwa byayo byinshi, imitungo ya HPMC ya mucoadhesive yitabiriwe cyane mubijyanye na sisitemu yo gutanga ibiyobyabwenge.Mucoadhesion bivuga ubushobozi bwibintu bimwe na bimwe byo kwifata hejuru yimitsi, kongera igihe cyo gutura no kongera ibiyobyabwenge.HPMC imiterere ya mucoadhesive ituma iba umukandida utanga ikizere mugushiraho uburyo bwo gutanga ibiyobyabwenge byibasira ingirabuzimafatizo nka gastrointestinal tract, surface ocular surface, and buccal cavity.Uru rupapuro rugamije gucengera mu miterere ya mucoadhesive ya HPMC, rugasobanura uburyo bwibikorwa byayo, ibintu bigira ingaruka kuri mucoadhesion, uburyo bwo gusuzuma, hamwe nuburyo butandukanye muburyo bwo gufata imiti.

2. Uburyo bwa Mucoadhesion:

Imiterere ya mucoadhesive ya HPMC ituruka ku miterere yihariye ya molekile n'imikoranire hamwe na mucosal.HPMC irimo hydrophilique hydroxyl groupe, iyifasha gukora imigozi ya hydrogène hamwe na glycoproteine ​​iboneka mumitsi.Iyi mikoranire ya intermolecular yorohereza ishyirwaho ryumubiri hagati ya HPMC nubuso bwa mucosal.Byongeye kandi, iminyururu ya polymer ya HPMC irashobora gufatana nu munyururu wa mucin, bikarushaho kwiyongera.Imikoreshereze ya electrostatike hagati ya mucins zishizwemo nabi hamwe nitsinda ryimikorere ikora neza kuri HPMC, nkamatsinda ya amonium ya quaternary, nayo agira uruhare mucoadhesion.Muri rusange, uburyo bwa mucoadhesion burimo imikoranire igoye yo guhuza hydrogène, guhuzagurika, no gukorana na electrostatike hagati ya HPMC nubuso bwa mucosal.

3. Ibintu bigira ingaruka kuri Mucoadhesion:

Ibintu byinshi bigira ingaruka kumiterere ya HPMC, bityo bikagira ingaruka mubikorwa byayo muri sisitemu yo gutanga ibiyobyabwenge.Ibi bintu birimo uburemere bwa molekuline ya HPMC, kwibumbira hamwe kwa polymer muburyo bwo gukora, urugero rwo gusimbuza (DS), na pH yibidukikije.Mubisanzwe, uburemere buke bwa HPMC bugaragaza imbaraga nyinshi za mucoadhesive bitewe no kwiyongera kwumunyururu hamwe na mucine.Mu buryo nk'ubwo, kwibanda kuri HPMC ni ingenzi cyane kugirango umuntu agere mucoadhesion ihagije, kubera ko imbaraga nyinshi cyane zishobora gutuma habaho geli, bikabuza gufatana.Urwego rwo gusimbuza HPMC narwo rufite uruhare runini, hamwe na DS yo hejuru yongera imitungo ya mucoadhesive mukongera umubare wamatsinda ya hydroxyl aboneka kugirango imikoranire.Byongeye kandi, pH yubuso bwa mucosal igira ingaruka kuri mucoadhesion, kuko ishobora kugira ingaruka kumiterere ya ionisation yimiryango ikora kuri HPMC, bityo igahindura imikoranire ya electrostatike na mucine.

4. Uburyo bwo gusuzuma:

Uburyo butandukanye bukoreshwa mugusuzuma imiterere ya mucoadhesive ya HPMC mumiti yimiti.Muri byo harimo gupima imbaraga zingana, ubushakashatsi bwa rheologiya, ex vivo no muri vivo mucoadhesion assays, hamwe nubuhanga bwo gufata amashusho nka microscopi ya atome imbaraga (AFM) hamwe na scanning electron microscopie (SEM).Ibipimo byimbaraga zingana bikubiyemo kwifashisha gel-polymer-mucin imbaraga zumukanishi no kugereranya imbaraga zisabwa kugirango zitandukane, zitanga ubumenyi bwimbaraga za mucoadhesive.Ubushakashatsi bwa Rheologiya busuzuma ubwiza nubwiza bwimiterere ya HPMC mubihe bitandukanye, bifasha mugutezimbere ibipimo fatizo.Ex vivo no muri vivo mucoadhesion isobanura harimo gukoresha imiti ya HPMC kumiterere ya mucosal ikurikirwa no kugereranya kwa adhesion ukoresheje tekinike nko gusesengura imiterere cyangwa gusuzuma amateka.Tekinike yo gufata amashusho nka AFM na SEM itanga amashusho yerekana mucoadhesion mugaragaza morphologie yimikoranire ya polymer-mucin kurwego rwa nanoscale.

5. Porogaramu muri sisitemu yo gutanga ibiyobyabwenge:

HPMC ya mucoadhesive imitungo isanga uburyo butandukanye muri sisitemu yo gutanga ibiyobyabwenge, bigafasha kurekura intego kandi zihoraho zo kuvura.Mu gutanga imiti yo mu kanwa, imiti ya HPMC ishingiye ku mucoadhesive irashobora gukurikiza mucosa gastrointestinal mucosa, kumara igihe cyo gutura ibiyobyabwenge no kongera kwinjiza.Sisitemu yo gutanga imiti ya buccal na sublingual ikoresha HPMC mugutezimbere kwifata kumitsi yo mu kanwa, byorohereza itangwa rya sisitemu cyangwa ryaho.Indwara ya Ophthalmic irimo HPMC ituma imiti igumana imiti igumana epitelium ya corneal na conjunctival epithelium, ikanoza imikorere yubuvuzi bwibanze.Byongeye kandi, uburyo bwo gutanga ibiyobyabwenge mu gitsina bukoresha gecoadhesive HPMC kugirango itange irekurwa rihoraho ryimiti yo kuboneza urubyaro cyangwa imiti igabanya ubukana, itanga inzira idahwitse yo gucunga ibiyobyabwenge.

Hydroxypropyl Methylcellulose (HPMC) yerekana ibintu bidasanzwe bya mucoadhesive, bigatuma iba ikintu cyiza muburyo butandukanye bwo gufata imiti.Ubushobozi bwayo bwo kwizirika hejuru ya mucosal byongera igihe cyo gutura ibiyobyabwenge, byongera kwinjiza, kandi byorohereza gutanga ibiyobyabwenge.Gusobanukirwa nuburyo bwa mucoadhesion, ibintu bigira ingaruka ku gufatira hamwe, uburyo bwo gusuzuma, hamwe nuburyo bukoreshwa muri sisitemu yo gutanga ibiyobyabwenge ni ngombwa mu gukoresha ubushobozi bwa HPMC mu miti y’imiti.Ubundi bushakashatsi no kunoza imikorere ya HPMC ishingiye kuri mucoadhesive itanga amasezerano yo kunoza imiti ivura no kubahiriza abarwayi mu bijyanye no gutanga ibiyobyabwenge.