He mucoadhesive ka HPMC

ʻO ka Hydroxypropyl Methylcellulose (HPMC) he polymer versatile me ka nui o nā noi i nā lāʻau lapaʻau, nā mea hoʻonaninani, nā meaʻai, a me nā ʻoihana ʻē aʻe.ʻO kekahi o kāna mau hiʻohiʻona koʻikoʻi kona mau waiwai mucoadhesive, kahi i waiwai nui ai i nā ʻōnaehana hoʻopuka lāʻau e kuhikuhi ana i nā ʻili mucosal.He mea nui ka hoʻomaopopo piha ʻana i nā waiwai mucoadhesive o HPMC no ka hoʻonui ʻana i kona hoʻohana ʻana i nā hana lāʻau lapaʻau no ka hoʻonui ʻana i nā hopena lapaʻau.

1. Hoʻolauna:

ʻO ka Hydroxypropyl Methylcellulose (HPMC) he semi-synthetic derivative o cellulose, i hoʻohana nui ʻia i loko o nā lāʻau lapaʻau ma muli o kona biocompatibility, non-toxicity, a me nā waiwai physicochemical kupaianaha.Ma waena o kāna mau noi he nui, ua loaʻa nā waiwai mucoadhesive o HPMC i ka nānā nui ʻana i ke kahua o nā ʻōnaehana lawe lāʻau.ʻO ka Mucoadhesion e pili ana i ka hiki o kekahi mau mea ke pili i ka mucosal surfaces, hoʻolōʻihi i ko lākou manawa noho a hoʻonui i ka lawe ʻana i ka lāʻau.ʻO ke ʻano mucoadhesive o HPMC e lilo ia i moho hoʻohiki no ka hoʻolālā ʻana i nā ʻōnaehana lawe lāʻau e kuhikuhi ana i nā ʻiʻo mucosal e like me ka ʻōpū o ka ʻōpū, ka ʻili o ka maka, a me ka lua buccal.Ke manaʻo nei kēia pepa e ʻimi i nā waiwai mucoadhesive o HPMC, e wehewehe ana i kāna hana o ka hana, nā mea e hoʻopiʻi ai i ka mucoadhesion, nā ʻano loiloi, a me nā noi like ʻole i loko o nā ʻano lāʻau lapaʻau.

2. Mechanism o Mucoadhesion:

Loaʻa nā waiwai mucoadhesive o HPMC mai kona ʻano molekala kū hoʻokahi a me nā pilina me nā ʻili mucosal.Loaʻa i ka HPMC nā pūʻulu hydrophilic hydroxyl, kahi e hiki ai iā ia ke hana i nā paʻa hydrogen me nā glycoproteins i loaʻa i nā membrane mucosal.Hoʻoikaika kēia pilina intermolecular i ka hoʻokumu ʻana i kahi paʻa kino ma waena o HPMC a me ka ʻili mucosal.Eia hou, hiki i nā kaulahao polymer o HPMC ke hoʻopili me nā kaulahao mucin, e hoʻonui hou i ka pili.ʻO nā pilina electrostatic ma waena o nā mucins i hoʻopiʻi maikaʻi ʻia a me nā pūʻulu hana i hoʻopiʻi maikaʻi ʻia ma HPMC, e like me nā hui ammonium quaternary, e kōkua pū i ka mucoadhesion.ʻO ka holoʻokoʻa, ʻo ke ʻano o ka mucoadhesion e pili ana i kahi pilina paʻakikī o ka hoʻopaʻa ʻana o ka hydrogen, entanglement, a me nā pilina electrostatic ma waena o HPMC a me nā ʻili mucosal.

3. Nā mea e pili ana i ka mucoadhesion:

Hoʻopili kekahi mau mea i nā waiwai mucoadhesive o HPMC, a laila e hoʻopilikia i kona pono i nā ʻōnaehana lawe lāʻau.ʻO kēia mau mea e pili ana i ka paona molekala o HPMC, ka neʻe ʻana o ka polymer i ka hoʻokumu ʻana, ke degere o ka hoʻololi ʻana (DS), a me ka pH o ke kaiapuni a puni.ʻO ka maʻamau, ʻoi aku ka nui o ke kaumaha o ka molekala HPMC i ka ikaika mucoadhesive ma muli o ka hoʻonui ʻia ʻana o ke kaulahao me nā mucins.Pēlā nō, he mea koʻikoʻi ka manaʻo maikaʻi loa o ka HPMC no ka loaʻa ʻana o ka mucoadhesion kūpono, no ka mea, hiki i ka nui o ke kiʻekiʻe kiʻekiʻe ke alakaʻi i ka hoʻokumu ʻana i ka gel, e pale ana i ka adhesion.He kuleana koʻikoʻi nō hoʻi ka pae o ka hoʻololi ʻana o HPMC, me ka DS kiʻekiʻe e hoʻonui ana i nā waiwai mucoadhesive ma o ka hoʻonui ʻana i ka nui o nā pūʻulu hydroxyl i loaʻa no ka launa pū ʻana.Eia kekahi, pili ka pH o ka ʻili mucosal i ka mucoadhesion, no ka mea hiki ke hoʻopili i ke kūlana ionization o nā pūʻulu hana ma HPMC, a laila hoʻololi i ka pilina electrostatic me nā mucins.

4. Nā ʻano o ka loiloi:

Hoʻohana ʻia kekahi mau ʻano hana e loiloi i nā waiwai mucoadhesive o HPMC i nā ʻano lāʻau lapaʻau.Hoʻopili kēia i nā ana ikaika tensile, nā haʻawina rheological, ex vivo a me in vivo mucoadhesion assays, a me nā ʻenehana kiʻi e like me ka atomic force microscopy (AFM) a me ka scanning electron microscopy (SEM).ʻO nā ana ikaika tensile e pili ana i ka hoʻokomo ʻana i ka gel polymer-mucin i nā ikaika mechanical a me ka helu ʻana i ka ikaika e pono ai no ka wehe ʻana, e hāʻawi ana i nā ʻike i ka ikaika mucoadhesive.Hōʻike nā haʻawina Rheological i ka viscosity a me nā waiwai adhesive o nā hoʻohālikelike HPMC ma lalo o nā kūlana like ʻole, e kōkua ana i ka hoʻonui ʻana i nā ʻāpana formulation.Ex vivo a in vivo mucoadhesion assays e pili ana i ka hoohana ana i ka HPMC formulations i ka mucosal surfaces a me ka helu ana o ka adhesion me ka hoohana ana i na hana e like me ka texture analysis or histological examination.Hāʻawi nā ʻenehana kiʻi e like me AFM a me SEM i ka hōʻoia ʻike ʻana o ka mucoadhesion ma ka hōʻike ʻana i ka morphology o nā pilina polymer-mucin ma ka pae nanoscale.

5. Nā noi ma nā ʻōnaehana lawe lāʻau:

Loaʻa nā waiwai mucoadhesive o HPMC i nā noi like ʻole i nā ʻōnaehana hoʻopuka lāʻau, hiki i ka hoʻokuʻu ʻia a hoʻomau mau ʻia o nā mea lapaʻau.I ka hāʻawi ʻana i ka lāʻau lapaʻau waha, hiki i ka HPMC-based mucoadhesive formulations ke pili i ka mucosa gastrointestinal, hoʻolōʻihi i ka manawa noho lāʻau a hoʻonui i ka absorption.Hoʻohana nā ʻōnaehana hoʻopuka lāʻau Buccal a me nā sublingual i ka HPMC e paipai i ka pili ʻana i nā ʻili mucosal waha, e hoʻomaʻamaʻa i ka ʻōnaehana a i ʻole ka lawe ʻana i ka lāʻau lapaʻau kūloko.Ophthalmic formulations loaʻa ka HPMC e hoʻoikaika i ka mālama ʻana i ka lāʻau lapaʻau ma o ka hoʻopili ʻana i ka epithelium corneal a me conjunctival, e hoʻomaikaʻi i ka pono o nā lāʻau lapaʻau.Eia kekahi, hoʻohana nā ʻōnaehana hoʻopuka lāʻau lapaʻau i ka mucoadhesive HPMC gels e hāʻawi i ka hoʻokuʻu mau ʻana o nā contraceptives a i ʻole antimicrobial agents, e hāʻawi ana i kahi ala non-invasive no ka hoʻokele lāʻau.

Hōʻike ʻo Hydroxypropyl Methylcellulose (HPMC) i nā waiwai mucoadhesive kupaianaha, e lilo ia i mea waiwai i nā ʻano hana lāʻau lapaʻau.ʻO kona hiki ke pili i ka mucosal surfaces e hoʻolōʻihi i ka manawa noho lāʻau, hoʻonui i ka absorption, a hoʻomaʻamaʻa i ka lawe ʻana i ka lāʻau lapaʻau.ʻO ka hoʻomaopopo ʻana i ke ʻano o ka mucoadhesion, nā mea e hoʻopili ai i ka adhesion, nā ʻano loiloi, a me nā noi i nā ʻōnaehana hoʻopuka lāʻau he mea nui ia no ka hoʻohana ʻana i ka pono piha o HPMC i nā hana lāʻau lapaʻau.ʻO ka noiʻi hou ʻana a me ka hoʻonui ʻana i nā ʻōnaehana mucoadhesive e pili ana i ka HPMC e paʻa i ka ʻōlelo no ka hoʻomaikaʻi ʻana i nā hopena therapeutic a me ka hoʻokō hoʻomanawanui ma ke kahua o ka lawe ʻana i ka lāʻau.