Hydroxypropyl Methylcellulose (HPMC) ke polima e feto-fetohang e nang le mefuta e mengata ea ts'ebeliso ea litlhare, litlolo, lijo le liindasteri tse ling.E 'ngoe ea litšoaneleho tsa eona tse hlokomelehang ke thepa ea eona ea ho khomarela li-mucoadhesive, tse etsang hore e be ea bohlokoa haholo lits'ebetsong tsa phepelo ea lithethefatsi tse shebaneng le bokaholimo ba mucosal.Kutloisiso e phethahetseng ea thepa ea HPMC ea sekhomaretsi e bohlokoa bakeng sa ho ntlafatsa ts'ebeliso ea eona mekhoeng ea litlama bakeng sa liphetho tse ntlafalitsoeng tsa kalafo.
1. Selelekela:
Hydroxypropyl Methylcellulose (HPMC) ke semi-synthetic derivative ea selulose, e sebelisoang haholo mekhoeng ea meriana ka lebaka la ho lumellana ha eona, ho se chefo, le litšobotsi tse tsotehang tsa physicochemical.Har'a lits'ebetso tsa eona tse ngata, thepa ea mucoadhesive ea HPMC e hapile tlhokomelo e kholo lefapheng la litsamaiso tsa phepelo ea lithethefatsi.Mucoadhesion e bolela bokhoni ba lintho tse itseng ho khomarela bokaholimo ba mucosal, ho lelefatsa nako ea bona ea ho lula le ho matlafatsa ho monya ha lithethefatsi.HPMC's "mucoadhesive nature" e etsa hore e be mokhethoa ea ts'episang ho rala lits'ebetso tsa phepelo ea lithethefatsi tse shebaneng le lisele tsa mucosal tse kang pampitšana ea mala, bokaholimo ba mahlo le mokokotlo oa mokokotlo.Pampiri ena e ikemiselitse ho kenella ka har'a thepa ea mucoadhesive ea HPMC, e hlakisa mokhoa oa eona oa ts'ebetso, lintlha tse susumetsang mucoadhesion, mekhoa ea tlhahlobo, le lits'ebetso tse fapaneng mekhoeng ea litlama.
2. Mokhoa oa ho kopanya Mucoadhesion:
Thepa ea mucoadhesive ea HPMC e tsoa ho sebopeho sa eona se ikhethang sa limolek'hule le ho sebelisana le bokaholimo ba mucosal.HPMC e na le lihlopha tsa hydrophilic hydroxyl, tse e nolofalletsang ho theha maqhama a hydrogen le li-glycoprotein tse teng ka har'a membrane ea mucosal.Tšebelisano ena ea li-intermolecular e thusa ho theha maqhama a 'mele pakeng tsa HPMC le bokaholimo ba mucosal.Ntle le moo, liketane tsa polymer tsa HPMC li ka hokahana le liketane tsa mucin, tsa ntlafatsa ho khomarela.Litšebelisano tsa motlakase lipakeng tsa li-mucins tse qosoang hampe le lihlopha tse sebetsang hantle tse qosoang hantle ho HPMC, joalo ka lihlopha tsa quaternary ammonium, le tsona li kenya letsoho molemong oa ho khomarela.Ka kakaretso, mochine oa mucoadhesion o kenyelletsa tšebelisano e rarahaneng ea hydrogen bonding, entanglement, le electrostatic interactions pakeng tsa HPMC le mucosal surfaces.
3. Lintlha tse Susumetsang ho Kopana ha Mucoadhesion:
Lintlha tse 'maloa li susumetsa thepa ea mucoadhesive ea HPMC, ka hona e ama ts'ebetso ea eona lits'ebetsong tsa phepelo ea lithethefatsi.Lintlha tsena li kenyelletsa boima ba limolek'hule tsa HPMC, khatello ea polymer ha ho etsoa, degree of substitution (DS), le pH ea tikoloho e potolohileng.Ka kakaretso, boima ba limolek'hule bo phahameng ba HPMC bo bonts'a matla a maholo a ho khomarela ka lebaka la ho kenngoa ha ketane le li-mucins.Ka mokhoa o ts'oanang, mahloriso a nepahetseng a HPMC a bohlokoa bakeng sa ho fihlela mucoadhesion e lekaneng, kaha ho tsepamisa maikutlo ho feteletseng ho ka lebisa ho thehoeng ha li-gel, ho sitisa ho khomarela.Tekanyo ea ho nkela sebaka sa HPMC le eona e phetha karolo ea bohlokoa, ka DS e phahameng e ntlafatsang thepa ea ho khomarela mucoadhesive ka ho eketsa palo ea lihlopha tse teng tsa hydroxyl bakeng sa tšebelisano.Ho feta moo, pH ea bokaholimo ba mucosal e susumetsa mucoadhesion, kaha e ka ama boemo ba ionization ba lihlopha tse sebetsang ho HPMC, kahoo e fetola litšebelisano tsa motlakase le li-mucins.
4. Mekhoa ea Tekolo:
Ho sebelisoa mekhoa e 'maloa ho lekola thepa ea mucoadhesive ea HPMC mekhoeng ea meriana.Tsena li kenyelletsa litekanyo tsa matla a thata, lithuto tsa rheological, ex vivo le in vivo mucoadhesion assays, le mekhoa ea ho nahana e kang atomic force microscopy (AFM) le scanning electron microscopy (SEM).Litekanyo tsa matla a thata li kenyelletsa ho beha gel ea polymer-mucin ho matla a mochini le ho lekanya matla a hlokahalang bakeng sa ho arohana, ho fana ka leseli mabapi le matla a sekhomaretsi.Lithuto tsa Rheological li lekola viscosity le thepa ea sekhomaretsi ea liforomo tsa HPMC tlasa maemo a fapaneng, e thusang ho ntlafatsa maemo a sebopeho.Litlhahlobo tsa Ex vivo le in vivo mucoadhesion li kenyelletsa ts'ebeliso ea liforomo tsa HPMC ho bokaholimo ba mucosal bo lateloang ke quantification ea adhesion ho sebelisoa mekhoa e kang tlhahlobo ea sebopeho kapa tlhahlobo ea nalane.Mekhoa ea ho etsa litšoantšo e kang AFM le SEM e fana ka tiiso ea pono ea mucoadhesion ka ho senola morphology ea litšebelisano tsa polymer-mucin boemong ba nanoscale.
5. Likopo ho Mecha ea Phano ea Lithethefatsi:
Thepa ea HPMC e kopanyang li-mucoadhesive e fumana lits'ebetso tse fapaneng lits'ebetsong tsa phano ea lithethefatsi, e nolofalletsang tokollo e lebisitsoeng le e tsitsitseng ea li-agent tsa kalafo.Phepelong ea lithethefatsi ka molomo, li-mucoadhesive formulations tse thehiloeng ho HPMC li ka khomarela mucosa ea mala, ho lelefatsa nako ea ho lula ha lithethefatsi le ho matlafatsa ho monya.Sistimi ea phepelo ea lithethefatsi ea Buccal le ea lipuo tse ling e sebelisa HPMC ho khothaletsa ho khomarela mahlahahlaha a molomo, ho tsamaisa phepelo ea lithethefatsi ea lehae.Metsoako ea mahlo e nang le HPMC e ntlafatsa ho boloka lithethefatsi tsa mahlo ka ho khomarela cornea le conjunctival epithelium, ho ntlafatsa katleho ea phekolo ea lihlooho.Ho feta moo, litsamaiso tsa phepelo ea lithethefatsi ka botšehaling li sebelisa li-gel tsa HPMC tsa mucoadhesive ho fana ka tokollo e tsitsitseng ea lithibela-pelehi kapa li-antimicrobial, tse fanang ka tsela e sa hlaseleng bakeng sa tsamaiso ea lithethefatsi.
Hydroxypropyl Methylcellulose (HPMC) e bonts'a thepa e makatsang ea li-mucoadhesive, e etsa hore e be karolo ea bohlokoa mekhoeng e fapaneng ea meriana.Bokhoni ba eona ba ho khomarela bokaholimo ba mucosal bo lelefatsa nako ea ho lula ha lithethefatsi, bo matlafatsa ho monya, 'me bo thusa phepelo ea lithethefatsi e lebisitsoeng.Ho utloisisa mochine oa mucoadhesion, lintlha tse susumetsang ho khomarela, mekhoa ea ho hlahloba, le mekhoa ea ho sebelisa mekhoa ea ho fana ka lithethefatsi ke ea bohlokoa bakeng sa ho sebelisa bokhoni bo feletseng ba HPMC mefuteng ea meriana.Liphuputso tse ling le ntlafatso ea litsamaiso tsa li-mucoadhesive tse thehiloeng ho HPMC li na le ts'episo ea ho ntlafatsa sephetho sa kalafo le ho latela mokuli lefapheng la phepelo ea lithethefatsi.
Nako ea poso: Apr-03-2024