IHydroxypropyl Methylcellulose (HPMC) yipolymer eguquguqukayo enoluhlu olubanzi lwezicelo kumayeza, izinto zokuthambisa, ukutya, kunye namanye amashishini.Enye yeempawu zayo eziphawulekayo yimpawu zayo ze-mucoadhesive, ezenza ukuba zixabiseke kwiinkqubo zokuhanjiswa kweziyobisi ezijoliswe kwi-mucosal surfaces.Ukuqondwa ngokucokisekileyo kweepropathi ze-HPMC zokuncamathelisa ukuncamathelisa kubalulekile ekwandiseni ukusetyenziswa kwayo kwimixube yoxubo lwamayeza ukwenzela iziphumo zonyango eziphuculweyo.
1. Intshayelelo:
I-Hydroxypropyl Methylcellulose (HPMC) yi-semi-synthetic derivative ye-cellulose, esetyenziswa ngokubanzi kwimixube yamayeza ngenxa yokuhambelana kwayo kwezinto eziphilayo, ukungabi nabutyhefu, kunye neempawu eziphawulekayo ze-physicochemical.Phakathi kwezicelo zayo ezininzi, iipropathi ze-HPMC ze-mucoadhesive ziye zafumana ingqwalasela ebalulekileyo kwinkalo yokuhanjiswa kweziyobisi.I-Mucoadhesion ibhekiselele kwisakhono sezinto ezithile zokubambelela kwi-mucosal surfaces, ukwandisa ixesha labo lokuhlala kunye nokuphucula ukufunxa kweziyobisi.Ubume be-mucoadhesive ye-HPMC iyenza ibe ngumgqatswa othembisayo wokuyila iinkqubo zokuhanjiswa kweziyobisi ezijolise kwizicubu ze-mucosal ezifana nomgudu wesisu, umphezulu we-ocular, kunye ne-buccal cavity.Eli phepha lijolise ekungeneni kwiipropati ze-mucoadhesive ze-HPMC, ukucacisa indlela yokusebenza kwayo, izinto ezichaphazela i-mucoadhesion, iindlela zokuvavanya, kunye nezicelo ezahlukeneyo ekuqulunqweni kwamayeza.
2. Indlela yokubambelela kwi-Mucoadhesion:
Iipropati ze-mucoadhesive ze-HPMC zivela kwisakhiwo sayo esisodwa se-molecular kunye nokusebenzisana kunye nemiphezulu ye-mucosal.I-HPMC iqulethe amaqela e-hydrophilic hydroxyl, eyenza ukuba yenze iibhondi ze-hydrogen kunye ne-glycoproteins ekhoyo kwiinwebu ze-mucosal.Le ntsebenziswano ye-intermolecular iququzelela ukusekwa kobudlelwane bomzimba phakathi kwe-HPMC kunye ne-mucosal surface.Ukongeza, amakhonkco e-polymer e-HPMC anokubanjiswa ngamatyathanga e-mucin, eyomeleza ngakumbi ukubambelela.Ukusebenzisana kwe-electrostatic phakathi kwe-mucins ehlawuliswa kakubi kunye namaqela asebenzayo ahlawulwe kakuhle kwi-HPMC, njengamaqela e-quaternary ammonium, nawo anegalelo kwi-mucoadhesion.Ngokubanzi, umatshini we-mucoadhesion ubandakanya ukudibana okuntsonkothileyo kwe-hydrogen bonding, entanglement, kunye ne-electrostatic interactions phakathi kwe-HPMC kunye ne-mucosal surfaces.
3. Izinto eziPhembelela i-Mucoadhesion:
Izinto ezininzi zinefuthe kwiipropathi ze-mucoadhesive ze-HPMC, ngaloo ndlela zichaphazela ukusebenza kwayo kwiinkqubo zokuhanjiswa kweziyobisi.Ezi zinto ziquka ubunzima bemolekyuli ye-HPMC, ukugxininiswa kwepolymer ekuqulunqweni, i-degree of substitution (DS), kunye ne-pH yendawo engqongileyo.Ngokubanzi, ubunzima bemolekyuli ephezulu ye-HPMC ibonisa amandla amakhulu okuncamathela kwe-mucoadhesive ngenxa yokonyuka komxokelelwane wekhonkco kunye ne-mucins.Ngokufanayo, ugxininiso olulolona lufanelekileyo lwe-HPMC lubalulekile ekufezekiseni i-mucoadhesion eyaneleyo, njengoko ugxininiso oluphezulu kakhulu lunokukhokelela ekwakhekeni kwejeli, luthintele ukuncamathela.Iqondo lokuthatha indawo ye-HPMC nalo lidlala indima ebalulekileyo, kunye ne-DS ephezulu yokuphucula iimpawu ze-mucoadhesive ngokwandisa inani lamaqela akhoyo e-hydroxyl ukwenzela ukusebenzisana.Ngaphezu koko, i-pH yendawo ye-mucosal ichaphazela i-mucoadhesion, njengoko inokuchaphazela imeko ye-ionization yamaqela asebenzayo kwi-HPMC, ngaloo ndlela iguqula ukusebenzisana kwe-electrostatic kunye ne-mucins.
4. Iindlela zoVavanyo:
Zininzi iindlela ezisetyenzisiweyo ukuvavanya iipropathi ze-mucoadhesive ze-HPMC kwimiqulu yamayeza.Ezi zibandakanya imilinganiselo yamandla okuqina, izifundo zerheological, i-ex vivo kunye ne-vivo mucoadhesion assays, kunye neendlela zokucinga ezifana ne-atomic force microscopy (AFM) kunye nokuskena i-electron microscopy (SEM).Imilinganiselo yamandla e-tensile ibandakanya ukubeka ijeli ye-polymer-mucin kumandla omatshini kunye nokulinganisa amandla afunekayo ukuze kukhutshwe i-detachment, ukubonelela ngengqiqo kumandla we-mucoadhesive.Izifundo ze-Rheological zivavanya i-viscosity kunye neempawu zokubambelela kwiifom ze-HPMC phantsi kweemeko ezahlukeneyo, zinceda ekuphuculeni iiparamitha zokuqulunqa.Uvavanyo lwe-Ex vivo kunye ne-vivo ye-mucoadhesion lubandakanya ukusetyenziswa kweefom ze-HPMC kwi-mucosal surfaces elandelwa yi-quantification ye-adhesion usebenzisa ubuchule obunjengohlalutyo lwe-texture okanye ukuhlolwa kwe-histological.Iindlela zokucinga ezifana ne-AFM kunye ne-SEM zinika ukuqinisekiswa okubonakalayo kwe-mucoadhesion ngokutyhila i-morphology yokusebenzisana kwe-polymer-mucin kwinqanaba le-nanoscale.
5. Izicelo kwiiNkqubo zokuHanjiswa kweZiyobisi:
Iipropati ze-HPMC ze-mucoadhesive zifumana izicelo ezahlukeneyo kwiinkqubo zokuhanjiswa kweziyobisi, ezivumela ukukhululwa okujoliswe kuyo kunye nokugcinwa okuqhubekayo kwee-arhente zonyango.Ekuhanjisweni kweziyobisi ngomlomo, i-HPMC-based based mucoadhesive formulations inokubambelela kwi-mucosa yesisu, ukwandisa ixesha lokuhlala kweziyobisi kunye nokuphucula ukufunxa.Iinkqubo ze-Buccal kunye neelwimi ezingaphantsi kokuhanjiswa kweziyobisi zisebenzisa i-HPMC ukukhuthaza ukubambelela kwi-oral mucosal surfaces, ukuququzelela ukuhanjiswa kweziyobisi ngokwenkqubo okanye kwendawo.Imixube ye-Ophthalmic equlethe i-HPMC iphucula ukugcinwa kwechiza lamehlo ngokubambelela kwi-epithelium ye-cornea kunye ne-conjunctival, iphucula ukusebenza konyango lwe-topical.Ngaphaya koko, iinkqubo zokuhanjiswa kweziyobisi kwilungu lobufazi zisebenzisa iijeli zeHPMC ezincamathelayo ukubonelela ngokukhutshwa okuzinzileyo kwezithinteli kukhulelwa okanye ii-antimicrobial agents, ezibonelela ngendlela engangeneleliyo yolawulo lwamachiza.
I-Hydroxypropyl Methylcellulose (HPMC) ibonisa iimpawu eziphawulekayo ze-mucoadhesive, iyenza ibe yinxalenye ebalulekileyo kwiindlela ezahlukeneyo zokwenziwa kwamayeza.Ukukwazi kwayo ukubambelela kumphezulu we-mucosal kwandisa ixesha lokuhlala kweziyobisi, kwandisa ukufunxa, kwaye kuququzelele ukuhanjiswa kwechiza ekujoliswe kulo.Ukuqonda indlela ye-mucoadhesion, izinto ezichaphazela ukubambelela, iindlela zokuvavanya, kunye nokusetyenziswa kwiinkqubo zokuhanjiswa kweziyobisi kubalulekile ekusebenziseni amandla apheleleyo e-HPMC ekuqulunqweni kwamayeza.Uphando olongezelelweyo kunye nokulungiswa kweenkqubo ze-mucoadhesive ze-HPMC zibambe isithembiso sokuphucula iziphumo zonyango kunye nokuthotyelwa kwesigulane kwintsimi yokuhanjiswa kweziyobisi.
Ixesha lokuposa: Apr-03-2024