Hydroxypropyl methylcellulose (HPMC) ke semi-synthetic, polymer e qhibilihang ka metsing e nkiloeng ho selulose.E sebelisoa haholo liindastering tse fapaneng, ho kenyelletsa le tsa meriana, lijo, kaho le litlolo, ka lebaka la thepa ea eona e ikhethang joalo ka ho tenya, ho tlama, ho etsa lifilimi le ho tsitsisa.Leha ho le joalo, ke habohlokoa ho hlokomela hore HPMC ha e na sebaka se khethehileng sa ho qhibiliha hobane ha e kene ka mokhoa oa 'nete oa ho qhibiliha joaloka lisebelisoa tsa kristale.Ho e-na le hoo, e kena ts'ebetsong ea ho senyeha ha mocheso ha e futhumala.
1. Thepa ea HPMC:
HPMC ke phofo e tšoeu ho isa ho e tšoeu e sa nkhang hamonate, e qhibilihang ka metsing le metsoako e mengata ea tlhaho.Thepa ea eona e fapana ho latela lintlha tse kang degree of substitution (DS), boima ba molek'hule, le kabo ea boholo ba likaroloana.Ka kakaretso, e na le litšobotsi tse latelang:
Sebopeho se seng sa ionic: HPMC ha e jare tefo ea motlakase ka tharollo, e etsa hore e lumellane le mefuta e mengata ea lisebelisoa tse ling.
Ho etsa lifilimi: HPMC e ka etsa lifilimi tse hlakileng, tse tenyetsehang ha li omme, tse fumanang lits'ebetso ka har'a likoahelo, lifiliming, le liforomong tsa litekanyetso tse laoloang tsa tokollo litlhare.
Thickening agent: E fana ka viscosity ho litharollo, e etsa hore e sebelisoe lihlahisoa tsa lijo, litlolo le meriana.
Hydrophilic: HPMC e na le kamano e phahameng ea metsi, e thusang ho qhibiliha ha eona le thepa ea ho etsa lifilimi.
2. Tšimoloho ea HPMC:
HPMC e entsoe ka letoto la karabelo ea lik'hemik'hale e kenyelletsang cellulose, propylene oxide, le methyl chloride.Mokhoa ona o kenyelletsa etherification ea cellulose e nang le propylene oxide e lateloang ke methylation e nang le methyl chloride.The degree of substitution (DS) ea hydroxypropyl le lihlopha tsa methoxy li ka laoloa ho lokisa thepa ea HPMC e hlahisoang.
3. Likopo tsa HPMC:
Indasteri ea meriana: HPMC e sebelisoa haholo e le mothusi oa litlhahlobo tsa meriana, ho kenyeletsoa matlapa, li-capsules, litharollo tsa mahlo, le mefuta ea litekanyetso tse laoloang.
Indasteri ea lijo: E sebelisoa e le seteifatsi, se tsitsisa, le emulsifier lihlahisoa tsa lijo tse kang li-sauces, sopho, ice cream le lintho tse bakang bohobe.
Indasteri ea kaho: HPMC e eketsoa lihlahisoa tse thehiloeng ho samente ho ntlafatsa ts'ebetso, ho boloka metsi, le ho khomarela.E boetse e sebelisoa ho li-adhesives tsa lithaele, lirekere le li-renders.
Indasteri ea litlolo: HPMC e sebelisoa mefuteng e fapaneng ea litlolo tse kang litlolo, litlolo, le li-shampoo bakeng sa ho tiisa le ho tsitsisa.
4. Boitšoaro ba Mocheso oa HPMC:
Joalokaha ho boletsoe pejana, HPMC ha e na sebaka se khethehileng sa ho qhibiliha ka lebaka la tlhaho ea eona ea amorphous.Ho e-na le hoo, ha mocheso o futhumala, ha o chesa.Ts'ebetso ea ho senyeha e kenyelletsa ho khaoha ha litlamo tsa lik'hemik'hale ka har'a ketane ea polymer, e lebisang ho thehoeng ha lihlahisoa tse senyehang tsa ho bola.
The degradation mocheso oa HPMC itšetlehile ka lintlha tse 'maloa, ho akarelletsa le boima ba eona ba molek'hule, tekanyo ea ho fetola, le ho ba teng ha li-additives.Ka tloaelo, ho senyeha ha mocheso oa HPMC ho qala ho pota 200 ° C 'me ho tsoela pele ka mocheso o ntseng o eketseha.Boemo ba ho senyeha bo ka fapana haholo ho latela sehlopha se ikhethileng sa HPMC le sekhahla sa ho futhumatsa.
Nakong ea ho senyeha ha mocheso, HPMC e sebetsana le mekhoa e 'maloa e ts'oanang, ho kenyelletsa le ho felloa ke metsi, depolymerization, le ho senyeha ha lihlopha tse sebetsang.Lihlahisoa tse ka sehloohong tsa ho bola li kenyelletsa metsi, carbon dioxide, carbon monoxide, methanol, le li-hydrocarbon tse fapa-fapaneng.
5. Mekhoa ea Tlhahlobo ea Thermal bakeng sa HPMC:
Boitšoaro ba mocheso oa HPMC bo ka ithutoa ho sebelisoa mekhoa e fapaneng ea tlhahlobo, ho kenyelletsa:
Tlhahlobo ea Thermogravimetric (TGA): TGA e lekanya tahlehelo ea boima ba sampuli e le mosebetsi oa mocheso, e fana ka tlhahisoleseding mabapi le botsitso ba eona ba mocheso le kinetics ea ho bola.
Differential scanning calorimetry (DSC): DSC e lekanya mocheso o phallang ho kena kapa ho tsoa sampuling e le ts'ebetso ea mocheso, e lumellang ho khetholla liphetoho tsa mekhahlelo le liketsahalo tsa mocheso tse kang ho qhibiliha le ho senyeha.
Fourier-transform infrared spectroscopy (FTIR): FTIR e ka sebelisoa ho lekola liphetoho tsa lik'hemik'hale ho HPMC nakong ea ho senyeha ha mocheso ka ho hlahloba liphetoho tsa lihlopha tse sebetsang le sebopeho sa limolek'hule.
6. Qetello:
HPMC ke polymer e feto-fetohang e nang le mefuta e mengata ea ts'ebeliso ea meriana, lijo, kaho le litlolo.Ho fapana le lisebelisoa tsa kristale, HPMC ha e na sebaka se khethehileng sa ho qhibiliha empa e senyeha ha mocheso o chesa.Mocheso oa mocheso o itšetlehile ka lintlha tse fapaneng 'me hangata o qala ho pota 200 ° C.Ho utloisisa boits'oaro ba mocheso oa HPMC ho bohlokoa bakeng sa ts'ebetso ea eona e nepahetseng le ts'ebetso liindastering tse fapaneng.
Nako ea poso: Mar-09-2024