HPMC bụ mucoadhesive

Hydroxypropyl Methylcellulose (HPMC) bụ polymer vasatail nwere ọtụtụ ngwa na ọgwụ, ntecha, nri, na ụlọ ọrụ ndị ọzọ.Otu n'ime njirimara ya a ma ama bụ ihe eji eme ya, nke na-eme ka ọ bụrụ ihe bara uru na usoro nnyefe ọgwụ na-elekwasị anya n'elu mucosal.Nghọta nke ọma gbasara akụrụngwa mucoadhesive HPMC dị mkpa maka ịkwalite ojiji ya na usoro ọgwụ maka nsonaazụ ọgwụgwọ emelitere.

1. Okwu mmalite:

Hydroxypropyl Methylcellulose (HPMC) bụ ihe na-emepụta mkpụrụ ndụ ihe nketa nke cellulose, nke a na-ejikarị eme ihe n'ụdị ọgwụ n'ihi ike ya, adịghị egbu egbu, na ihe ndị dị ịrịba ama physicochemical.N'ime ọtụtụ ngwa ya, akụrụngwa mucoadhesive nke HPMC enwetala nlebara anya dị ukwuu na ngalaba nke usoro nnyefe ọgwụ.Mucoadhesion na-ezo aka n'ikike nke ụfọdụ ihe na-agbaso n'elu mucosal, na-agbatị oge obibi ha na ịkwalite mmịnye ọgwụ.Ọdịdị mucoadhesive nke HPMC na-eme ka ọ bụrụ onye na-ekwe nkwa maka ịmepụta usoro nnyefe ọgwụ na-elekwasị anya na anụ ahụ mucosal dị ka eriri afọ eriri afọ, elu anya, na oghere buccal.Akwụkwọ a chọrọ ịbanye n'ime mucoadhesive Njirimara nke HPMC, na-akọwapụta usoro ya, ihe ndị na-emetụta mucoadhesion, ụzọ nyocha, na ngwa dị iche iche na usoro ọgwụ.

2. Usoro nke Mucoadhesion:

Njirimara mucoadhesive nke HPMC na-esi na nhazi ya pụrụ iche na mmekọrịta ya na elu mucosal.HPMC nwere otu hydrophilic hydroxyl, nke na-enyere ya aka ịmepụta njikọ hydrogen na glycoproteins dị na akpụkpọ anụ mucosal.Mmekọrịta intermolecular a na-enyere aka nguzobe njikọ anụ ahụ n'etiti HPMC na elu mucosal.Na mgbakwunye, ụdọ polymer nke HPMC nwere ike jikọta ya na agbụ mucin, na-eme ka adhesion dịkwuo elu.Mmekọrịta electrostatic n'etiti mucins ebubo na-adịghị mma yana otu ndị na-arụ ọrụ nke ọma na HPMC, dị ka otu ammonium quaternary, na-enyekwa aka na mucoadhesion.N'ozuzu, usoro nke mucoadhesion na-agụnye mkparịta ụka dị mgbagwoju anya nke njikọ hydrogen, njikọ, na mmekọrịta electrostatic n'etiti HPMC na elu mucosal.

3. Ihe na-emetụta Mucoadhesion:

Ọtụtụ ihe na-emetụta njirimara mucoadhesive nke HPMC, si otú ahụ na-emetụta arụmọrụ ya na sistemụ nnyefe ọgwụ.Ihe ndị a gụnyere ịdị arọ molekụla nke HPMC, itinye uche nke polymer na nhazi, ogo nnọchi (DS), na pH nke gburugburu gburugburu.Na mkpokọta, HPMC dị arọ molekụla dị elu na-egosipụta ike mucoadhesive ka ukwuu n'ihi ụbara yinye njikọ na mucins.N'otu aka ahụ, itinye uche kacha mma nke HPMC dị oke mkpa maka ịnweta mucoadhesion zuru oke, ebe ọ bụ na oke elu nwere ike ibute nguzobe gel, na-egbochi nrapanye.Ogo nke nnọchi nke HPMC na-arụkwa ọrụ dị mkpa, yana DS dị elu na-eme ka akụrụngwa mucoadhesive na-abawanye site na ịbawanye ọnụ ọgụgụ nke otu hydroxyl dị maka mmekọrịta.Ọzọkwa, pH nke mucosal elu na-emetụta mucoadhesion, n'ihi na ọ nwere ike imetụta ọnọdụ ionization nke otu ndị na-arụ ọrụ na HPMC, si otú ahụ na-agbanwe mmekọrịta electrostatic na mucins.

4. Ụzọ nyocha:

A na-eji ọtụtụ ụzọ iji nyochaa njirimara mucoadhesive nke HPMC na usoro ọgwụ.Ndị a gụnyere nha ike tensile, ọmụmụ rheological, ex vivo na in vivo mucoadhesion assays, yana usoro onyonyo dị ka atomiki Force microscopy (AFM) na scanning eletrọn microscopy (SEM).Ntụle ike tensile gụnyere idobe polymer-mucin gel n'aka ndị ọrụ arụ ọrụ yana ịkọwa ike achọrọ maka ikewapụ, na-enye nghọta na ike mucoadhesive.Ọmụmụ ihe ọmụmụ rheological na-enyocha viscosity na nrapado Njirimara nke usoro HPMC n'okpuru ọnọdụ dị iche iche, na-enyere aka na njikarịcha nke usoro nhazi.Ex vivo na in vivo mucoadhesion assays gụnyere itinye usoro HPMC n'elu mucosal na-esote ọnụọgụ nke adhesion site na iji usoro dị ka nyocha ederede ma ọ bụ nyocha akụkọ ihe mere eme.Usoro eserese dị ka AFM na SEM na-enye nkwenye anya nke mucoadhesion site n'ikpughe ọdịdị nke mmekọrịta polymer-mucin na ọkwa nanoscale.

5. Ngwa dị na sistemụ nnyefe ọgwụ:

Ngwongwo mucoadhesive nke HPMC na-achọta ngwa dị iche iche na sistemụ nnyefe ọgwụ, na-eme ka ntọhapụ ndị ezubere iche maka ọgwụgwọ na-adịgide adịgide.Na nnyefe ọgwụ ọnụ, usoro mucoadhesive dabeere na HPMC nwere ike ịrapara na mucosa eriri afọ, na-agbatị oge obibi ọgwụ na ịkwalite nnabata.Sistemụ nnyefe ọgwụ na sublingual na-eji HPMC kwalite nrapagide na elu mucosal ọnụ, na-eme ka usoro nnyefe ma ọ bụ nke mpaghara.Usoro anya nke nwere HPMC na-akwalite njide ọgwụ anya site na ịrapagidesi ike na corneal na conjunctival epithelium, na-eme ka ọ dị mma nke ọgwụgwọ n'elu.Ọzọkwa, usoro nnyefe ọgwụ ikpu na-eji mucoadhesive HPMC gels iji nye ntọhapụ na-adịgide adịgide nke mgbochi mgbochi ma ọ bụ ọgwụ nje, na-enye ụzọ na-adịghị emerụ ahụ maka nchịkwa ọgwụ.

Hydroxypropyl Methylcellulose (HPMC) na-egosiputa Njirimara mucoadhesive dị ịrịba ama, na-eme ka ọ bụrụ akụkụ bara uru na usoro ọgwụ dị iche iche.Ikike ya ịrapagidesi ike na elu mucosal na-agbatị oge obibi ọgwụ, na-eme ka mmịnye dịkwuo mma, ma na-eme ka nnyefe ọgwụ ezubere iche dị mfe.Ịghọta usoro nke mucoadhesion, ihe ndị na-emetụta adhesion, ụzọ nyocha, na ngwa na usoro nnyefe ọgwụ dị mkpa maka ijikwa ike zuru oke nke HPMC na usoro ọgwụ.Nnyocha ndị ọzọ na njikarịcha sistemụ mucoadhesive dabeere na HPMC na-ekwe nkwa maka ịkwalite nsonaazụ ọgwụgwọ yana nnabata onye ọrịa n'ọhịa nnyefe ọgwụ.