IHydroxypropylmethylcellulose (HPMC) iyi-polymer esebenzayo etholakala ku-cellulose esetshenziswa kakhulu ezimbonini ezahlukahlukene ngenxa yezakhiwo zayo ezihlukile.I-compound ihlanganiswa ngochungechunge lwezinguquko zamakhemikhali ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo.
impahla eluhlaza:
Umthombo: I-Cellulose iwumthombo oyinhloko we-HPMC, egcwele imvelo futhi ekhishwe ezitshalweni.I-Wood pulp kanye ne-cotton linters yimithombo evame kakhulu ye-cellulose.
Ukuhlukaniswa: Inqubo yokukhipha ihilela ukudiliza izindonga zamaseli esitshalo kanye nokuhlukanisa imicu ye-cellulose.Izindlela ezahlukahlukene zamakhemikhali nezemishini zingasetshenziselwa le njongo.
I-Propylene oxide:
Umthombo: I-Propylene oxide iyinhlanganisela yezinto eziphilayo etholakala emithonjeni ye-petrochemical.
Umsebenzi: I-Propylene oxide isetshenziselwa ukwethula amaqembu e-hydroxypropyl kuma-molecule e-cellulose ngesikhathi senqubo yokuhlanganiswa, ithuthukisa ukunyibilika kwamanzi futhi iguqule izakhiwo ezibonakalayo ze-HPMC ewumphumela.
I-Methyl chloride:
Umthombo: I-Methyl chloride iyi-hydrocarbon ene-chlorinated engahlanganiswa kusuka ku-methanol.
Umsebenzi: I-Methyl chloride isetshenziselwa ukwethula amaqembu e-methyl kuma-molecule e-cellulose, okunomthelela ku-hydrophobicity yonke ye-HPMC.
I-sodium hydroxide (NaOH):
Umthombo: I-sodium hydroxide, eyaziwa nangokuthi i-caustic soda, iyisisekelo esiqinile futhi iyatholakala ngokuthengiswa.
Umsebenzi: I-NaOH isetshenziselwa ukwenza ukusabela nokulungisa inani le-pH lengxube yokusabela phakathi nenqubo yokuhlanganisa.
I-synthesis:
Ukuhlanganiswa kwe-HPMC kuhilela izinyathelo ezimbalwa, futhi uhlelo lokusabela lungafingqwa ngale ndlela elandelayo:
I-Alkalizing:
I-Cellulose iphathwa nge-sodium hydroxide ukuze ikhiqize i-alkaline cellulose.
I-alkali cellulose ibe isisabela nge-propylene oxide ukwethula amaqembu e-hydroxypropyl.
I-Methylation:
I-Hydroxypropylated cellulose iphinde iphendule nge-methyl chloride ukwethula amaqembu e-methyl.
Lesi sinyathelo sinikeza i-polymer ukuzinza okwengeziwe kanye ne-hydrophobicity.
Ukungathathi hlangothi nokuhlunga:
Ingxube yokusabela yayingashintshiwe ukuze isuse isisekelo eseqile.
Ukuhlunga kwenziwa ukuze kuhlukaniswe i-cellulose eshintshiwe.
Ukugeza nokomisa:
Umkhiqizo ohlukanisiwe uyagezwa bese uyomiswa ukuze kutholwe i-hydroxypropyl methylcellulose iyimpushana noma ifomu eliyimbudumbudu.
Isici sokunyibilika kwe-HPMC:
I-HPMC ayincibiliki emanzini futhi ukunyibilika kwayo kungalungiswa ngokuya ngezinga lokushintshanisa i-hydroxypropyl namaqembu e-methyl.
Amandla okwenza ifilimu:
I-HPMC yenza amafilimu aguquguqukayo, asobala afanele ukusetshenziswa ezimbonini zemithi nezokudla.
I-Viscosity:
I-viscosity yesisombululo se-HPMC ingalawulwa futhi ivame ukusetshenziswa njenge-ejenti yokuqina kanye ne-gelling ekwakhiweni okuhlukahlukene.
I-Thermal Gelation:
Amabanga athile e-HPMC abonisa izici ze-thermogelling, akha ijeli lapho ishiselwa futhi ibuyela kusixazululo lapho selehlile.
Umsebenzi ongaphezulu:
I-HPMC ingasetshenziswa njenge-surfactant, futhi umsebenzi wayo ongaphezulu uthintwa yizinga lokushintsha.
Izidakamizwa ezisetshenziswayo ze-HPMC:
I-HPMC isetshenziswa kakhulu ekwenziweni kwemithi njengezibophezelo, ama-disintegrants, nama-ejenti okukhululwa alawulwayo kumaphilisi namaphilisi.
Imboni yezokwakha:
Emkhakheni wezokwakha, i-HPMC isetshenziswa njengokujiya emikhiqizweni esekwe usimende njengodaka namathayela anamathelayo.
imboni yokudla:
I-HPMC isetshenziswa embonini yezokudla njengento ejiyayo, i-emulsifier kanye ne-stabilizer emikhiqizweni eyahlukene, okuhlanganisa amasoso, ama-dessert no-ayisikhilimu.
Imikhiqizo yokunakekelwa komuntu siqu:
Ezimonyoni nasezikhiqizweni zokunakekelwa komuntu siqu, i-HPMC isetshenziswa ekwenziweni okufana nokhilimu, izinto zokuthambisa kanye nama-shampoos ngenxa yokujiya kwayo nokuzinza.
Amapende nama-Coatings:
I-HPMC yengezwa kumapende nasezimbotsheni ukuze kulawulwe i-viscosity, kuthuthukiswe izakhiwo zohlelo futhi kuthuthukiswe izici zokwenza ifilimu.
Izixazululo ze-Ophthalmic:
I-HPMC isetshenziswa kumaconsi esweni nasezinyembezini zokwenziwa ngenxa yokuhambisana kwayo kwezinto eziphilayo kanye nezakhiwo zokunamathisela i-mucoadhesive.
Ekuphetheni:
I-Hydroxypropylmethylcellulose (HPMC) iyi-polymer ephawulekayo ehlanganiswe kusukela ku-cellulose yesisetshenziswa esivuselelekayo.Izakhiwo zayo ezinemisebenzi eminingi kanye nohlu olubanzi lwezinhlelo zokusebenza ziyenza ibe isithako esiyinhloko ezimbonini ezihlukahlukene, kusukela kwezokwelapha kuya kwezokwakha nokudla.Ngokukhetha ngokucophelela izinto zokusetshenziswa kanye nokulawula amapharamitha okuhlanganiswa, ama-HPMC anezici ezenziwe ngokwezifiso angakhiqizwa ukuze ahlangabezane nezidingo ezithile zezinhlelo zokusebenza ezahlukene.Njengoba ubuchwepheshe nezidingo ziqhubeka nokuvela, i-HPMC kungenzeka ihlale ibambe iqhaza ekusunguleni izinto ezintsha nasekuthuthukisweni kwemikhiqizo esimeme kuzo zonke izimboni.
Isikhathi sokuthumela: Dec-18-2023