Hydroxypropylmethylcellulose (HPMC) yog cov khoom siv ntau yam polymer muab los ntawm cov cellulose uas tau siv dav hauv ntau qhov kev lag luam vim nws cov khoom tshwj xeeb.Lub compound yog synthesized los ntawm ib tug series ntawm tshuaj hloov kho rau cellulose, ib tug natural polymer pom nyob rau hauv cov nroj tsuag cell phab ntsa.
raw khoom:
Source: Cellulose yog cov khoom siv tseem ceeb ntawm HPMC, uas muaj ntau nyob rau hauv cov xwm thiab muab rho tawm los ntawm cov nroj tsuag.Ntoo pulp thiab paj rwb linters yog feem ntau qhov chaw ntawm cellulose.
Kev rho tawm: Cov txheej txheem rho tawm cuam tshuam nrog kev rhuav tshem cov phab ntsa ntawm cov nroj tsuag thiab cais cov cellulose fibers.Ntau yam tshuaj thiab siv tshuab siv tau rau lub hom phiaj no.
Propylene oxide:
Tau qhov twg los: propylene oxide yog cov organic compound tau los ntawm petrochemical qhov chaw.
Kev Ua Haujlwm: propylene oxide yog siv los qhia cov pab pawg hydroxypropyl rau hauv cellulose molecules thaum lub sij hawm tsim cov txheej txheem, txhim kho cov dej solubility thiab hloov cov khoom ntawm lub cev ntawm HPMC.
Methyl chloride:
Source: Methyl chloride yog chlorinated hydrocarbon uas tuaj yeem tsim los ntawm methanol.
Kev Ua Haujlwm: Methyl chloride yog siv los qhia cov pab pawg methyl rau hauv cellulose molecules, uas ua rau tag nrho hydrophobicity ntawm HPMC.
Sodium hydroxide (NaOH):
Source: Sodium hydroxide, tseem hu ua caustic soda, yog lub hauv paus muaj zog thiab muaj kev lag luam.
Muaj nuj nqi: NaOH yog siv los catalyze cov tshuaj tiv thaiv thiab kho tus nqi pH ntawm cov tshuaj tiv thaiv sib tov thaum lub sij hawm txheej txheem synthesis.
Synthesis:
Lub synthesis ntawm HPMC suav nrog ob peb kauj ruam, thiab cov txheej txheem tshuaj tiv thaiv tuaj yeem ua tiav raws li hauv qab no:
Alkalizing:
Cellulose yog kho nrog sodium hydroxide los tsim alkaline cellulose.
Alkali cellulose yog ces reacted nrog propylene oxide los qhia hydroxypropyl pawg.
Methylation:
Hydroxypropylated cellulose yog ntxiv reacted nrog methyl chloride los qhia methyl pawg.
Cov kauj ruam no muab cov polymer ntxiv stability thiab hydrophobicity.
Neutralization thiab filtering:
Cov tshuaj tiv thaiv sib xyaw yog neutralized kom tshem tawm ntau dhau.
Lim tau ua los cais cov hloov kho cellulose.
Ntxuav thiab ziab:
Cov khoom sib cais yog ntxuav thiab qhuav kom tau hydroxypropyl methylcellulose hauv hmoov los yog granular daim ntawv.
Yam ntxwv solubility ntawm HPMC:
HPMC yog dej-soluble thiab nws solubility tuaj yeem hloov kho raws li qib kev hloov ntawm hydroxypropyl thiab methyl pawg.
Film forming peev xwm:
HPMC cov ntaub ntawv hloov tau yooj yim, pob tshab zaj duab xis haum rau kev siv hauv kev lag luam tshuaj thiab zaub mov.
viscosity:
Lub viscosity ntawm HPMC cov tshuaj tuaj yeem tswj tau thiab feem ntau yog siv los ua cov thickener thiab gelling tus neeg sawv cev hauv ntau cov qauv.
Thermal gelation:
Qee qib ntawm HPMC muaj cov khoom siv thermogelling, tsim cov gel thaum cua sov thiab rov qab mus rau cov tshuaj thaum txias.
Kev ua haujlwm saum npoo:
HPMC tuaj yeem siv los ua ib qho surfactant, thiab nws cov haujlwm saum npoo yog cuam tshuam los ntawm kev hloov pauv.
Cov tshuaj siv ntawm HPMC:
HPMC yog dav siv nyob rau hauv cov tshuaj formulations li binders, disintegrants, thiab tswj tso tawm cov neeg sawv cev nyob rau hauv cov ntsiav tshuaj thiab tsiav tshuaj.
Kev tsim kho kev lag luam:
Hauv kev tsim kho, HPMC yog siv los ua cov thickener hauv cov khoom siv cement xws li mortars thiab pobzeb adhesives.
kev lag luam zaub mov:
HPMC yog siv rau hauv kev lag luam khoom noj khoom haus ua cov thickener, emulsifier thiab stabilizer nyob rau hauv ntau yam khoom, nrog rau cov kua ntses, khoom qab zib thiab ice cream.
Cov khoom siv tu tus kheej:
Hauv cov tshuaj pleev ib ce thiab cov khoom siv tu tus kheej, HPMC yog siv rau hauv cov tshuaj pleev ib ce, tshuaj pleev thiab tshuaj zawv plaub hau vim nws cov khoom ua kom tuab thiab ruaj khov.
Paints thiab Coatings:
HPMC tau ntxiv rau cov xim thiab cov txheej txheem los tswj cov viscosity, txhim kho daim ntawv thov cov khoom thiab txhim kho cov khoom ua yeeb yaj kiab.
Ophthalmic Solutions:
HPMC yog siv rau hauv qhov muag tee thiab kua muag dag vim nws biocompatibility thiab mucoadhesive zog.
nyob rau hauv xaus:
Hydroxypropylmethylcellulose (HPMC) yog ib qho zoo tshaj plaws polymer synthesized los ntawm cov khoom siv txuas ntxiv dua tshiab cellulose.Nws cov khoom siv ntau yam thiab ntau yam kev siv ua rau nws yog cov khoom tseem ceeb hauv ntau qhov kev lag luam, los ntawm kev siv tshuaj mus rau kev tsim kho thiab khoom noj.Los ntawm kev ua tib zoo xaiv cov khoom siv raw thiab kev tswj cov khoom sib txuas, HPMCs nrog cov khoom siv kho kom haum tuaj yeem tsim kom tau raws li cov kev xav tau tshwj xeeb ntawm cov ntawv thov sib txawv.Raws li thev naus laus zis thiab kev xav tau txuas ntxiv mus, HPMC zoo li yuav nyob twj ywm tseem ceeb hauv kev tsim kho tshiab thiab txhim kho cov khoom lag luam ruaj khov thoob plaws kev lag luam.
Post lub sij hawm: Dec-18-2023