HPMC ukunyibilika kwizinyibilikisi eziphilayo

IHydroxypropyl methylcellulose (HPMC) yipolima enyibilikayo emanzini eqhele ukusetyenziswa kumashishini ahlukeneyo, kuquka ukwakhiwa, amayeza, kunye nemveliso yokutya.Nangona kunjalo, i-HPMC inokunyibilika kwizinyibilikisi ezithile eziphilayo, ezinokubonelela ngokuguquguquka okongezelelweyo kunye nokuguquguquka kwezicelo ezahlukeneyo.

I-solubility ye-HPMC kwi-solvents yezinto eziphilayo ixhomekeke kwizinto ezahlukeneyo, kubandakanywa ubunzima be-molecular ye-polymer, iqondo lokutshintshwa kwe-hydroxypropyl kunye namaqela e-methyl, kunye neepropati ze-polarity kunye ne-hydrogen-bonding ye-solvent.Ngokubanzi, i-HPMC enobunzima obuphezulu bemolekyuli kunye nenqanaba lokuthatha indawo iya kuba ne-solubility ephantsi kwizinyibilikisi zendalo.Ngokwahlukileyo, izinyibilikisi ezine-polarity ephezulu kunye neepropathi ezinamandla zokudibanisa i-hydrogen ziya kuba nokunyibilika okukhulu.

Ezinye izinyibilikisi eziqhelekileyo eziphilayo ezinokunyibilika HPMC ziquka methanol, ethanol, isopropanol, acetone, kunye ethyl acetate.I-Methanol kunye ne-ethanol zezona zinyibiliki zisetyenziswa kakhulu kwi-HPMC, kwaye zinokunyibilikisa i-HPMC ekugxininiseni ukusuka kwi-5-10% ngobunzima.I-Isopropanol inokunyibilikisa i-HPMC ekugxininiseni ukuya kwi-20% ngobunzima, ngelixa i-acetone kunye ne-ethyl acetate inokutshabalalisa i-HPMC ekugxininiseni ukuya kwi-5% ubunzima.

I-solubility ye-HPMC kwi-solvents ye-organic inokuchatshazelwa liqela lezinto, kubandakanywa ubushushu be-solvent, indlela yokuxuba, kunye nobukho bezinye izongezo okanye izithako.Ngokubanzi, ukwandisa ubushushu be-solvent kunokunyusa ukunyibilika kwe-HPMC, nangona iqondo lokushisa akufanele libe phezulu kakhulu kubangele ukuthotywa okanye ukubola kwepolymer.Ukongezelela, ezinye iindlela zokuxuba, ezifana ne-ultrasonic okanye i-magnetic stirring, inokuphucula i-solubility ye-HPMC ngokukhuthaza ukusabalalisa okungcono kunye nokusabalalisa i-polymer kwi-solvent.

I-solubility ye-HPMC kwi-solvents eziphilayo inokuchatshazelwa kubukho bezinye izongezo okanye izithako.Umzekelo, ii-surfactants okanye i-cosolvents zingasetyenziselwa ukuphucula ukunyibilika kwe-HPMC kwizinyibilikisi ezithile eziphilayo, okanye ukunyenyisa iipropathi zemveliso yokugqibela.Nangona kunjalo, kubalulekile ukuvavanya ngononophelo ezi zongezo ukuqinisekisa ukuba aziphazamisi ukunyibilika okanye iipropathi zeHPMC ngeendlela ebezingalindelekanga.

Enye ingqalelo ebalulekileyo xa usebenzisa i-HPMC kwizinyibilikisi zendalo yinto enokwenzeka yokwahlulwa kwesigaba okanye imvula yepolymer.Oku kunokwenzeka ukuba i-concentration ye-HPMC kwi-solvent iphezulu kakhulu, okanye ukuba i-solvent ayihambelani ne-HPMC.Ukongeza, ezinye izinyibilikisi zinokubangela ukuba i-HPMC yenze iijeli okanye ezinye izinto ezizii-semi-solid, ezinokuba luncedo kwezinye izicelo kodwa zisenokunganqweneleki kwabanye.

Ukuqukumbela, i-solubility ye-HPMC kwi-solvents ye-organic inokubonelela ngokuguquguquka okongezelelweyo kunye nokuguquguquka kwezicelo ezahlukeneyo, kodwa kubalulekile ukuqwalasela ngokucophelela iimpawu ze-solvent kunye ne-HPMC, kunye nendlela yokuxuba kunye naziphi na ezinye izongezo okanye izithako.Ngokukhetha i-solvent efanelekileyo kunye nokulandela iindlela ezifanelekileyo zokuxuba kunye nokuvavanya, kunokwenzeka ukufezekisa ukunyibilika okuphezulu kunye neepropati zoluhlu olubanzi lweemveliso ezisekelwe kwi-HPMC.