HPMC solubility hauv cov kuab tshuaj organic

Hydroxypropyl methylcellulose (HPMC) yog cov dej-soluble polymer feem ntau siv hauv ntau yam lag luam, suav nrog kev tsim kho, tshuaj, thiab kev tsim khoom noj.Txawm li cas los xij, HPMC tseem tuaj yeem yaj hauv qee cov kuab tshuaj organic, uas tuaj yeem muab tau yooj yim dua thiab ntau yam rau ntau yam kev siv.

Kev solubility ntawm HPMC nyob rau hauv cov kuab tshuaj organic nyob ntawm ntau yam, nrog rau qhov hnyav molecular ntawm cov polymer, qib ntawm kev hloov ntawm hydroxypropyl thiab methyl pawg, thiab polarity thiab hydrogen-bonding zog ntawm cov kuab tshuaj.Feem ntau, HPMC nrog qhov hnyav dua molecular thiab qib ntawm kev hloov pauv yuav muaj qis solubility hauv cov kuab tshuaj organic.Nyob rau hauv sib piv, cov kuab tshuaj nrog polarity ntau dua thiab muaj zog hydrogen bonding zog yuav muaj ntau dua solubility.

Qee cov kuab tshuaj organic uas tuaj yeem yaj HPMC muaj xws li methanol, ethanol, isopropanol, acetone, thiab ethyl acetate.Methanol thiab ethanol yog cov kuab tshuaj feem ntau siv rau HPMC, thiab lawv tuaj yeem yaj HPMC hauv qhov ntau ntawm 5-10% los ntawm qhov hnyav.Isopropanol tuaj yeem yaj HPMC hauv qhov siab txog li 20% los ntawm qhov hnyav, thaum acetone thiab ethyl acetate tuaj yeem yaj HPMC hauv qhov siab txog li 5% los ntawm qhov hnyav.

Kev solubility ntawm HPMC hauv cov kuab tshuaj organic tuaj yeem cuam tshuam los ntawm ntau yam, suav nrog qhov kub thiab txias ntawm cov kuab tshuaj, cov txheej txheem ntawm kev sib xyaw, thiab muaj lwm yam tshuaj ntxiv lossis cov khoom xyaw.Feem ntau, nce qhov kub ntawm cov kuab tshuaj tuaj yeem ua rau cov kuab tshuaj HPMC nce ntxiv, txawm hais tias qhov kub thiab txias yuav tsum tsis txhob siab dhau los ua rau degradation lossis decomposition ntawm cov polymer.Tsis tas li ntawd, qee txoj kev sib xyaw, xws li ultrasonic lossis sib nqus nplawm, tuaj yeem txhim kho cov solubility ntawm HPMC los ntawm kev txhawb nqa zoo dua dispersion thiab faib cov polymer hauv cov kuab tshuaj.

Kev solubility ntawm HPMC hauv cov kuab tshuaj organic kuj tuaj yeem cuam tshuam los ntawm kev muaj lwm cov tshuaj ntxiv lossis cov khoom xyaw.Piv txwv li, surfactants los yog cosolvents yuav siv tau los txhim kho cov solubility ntawm HPMC nyob rau hauv tej yam organic solvents, los yog kho cov khoom ntawm cov khoom kawg.Txawm li cas los xij, nws yog ib qho tseem ceeb uas yuav tau ua tib zoo sim cov tshuaj ntxiv no kom ntseeg tau tias lawv tsis cuam tshuam nrog kev solubility lossis cov khoom ntawm HPMC hauv txoj kev tsis xav tau.

Ib qho kev txiav txim siab tseem ceeb thaum siv HPMC hauv cov kuab tshuaj organic yog lub peev xwm rau theem sib cais lossis nag lossis daus ntawm cov polymer.Qhov no tuaj yeem tshwm sim yog tias qhov concentration ntawm HPMC hauv cov kuab tshuaj siab dhau, lossis yog tias cov kuab tshuaj tsis sib haum nrog HPMC.Tsis tas li ntawd, qee cov kuab tshuaj tuaj yeem ua rau HPMC tsim cov gels lossis lwm yam khoom siv ib nrab, uas tuaj yeem pab tau rau qee qhov kev siv tab sis tej zaum yuav tsis tsim nyog rau lwm tus.

Hauv kev xaus, kev solubility ntawm HPMC hauv cov kuab tshuaj organic tuaj yeem muab tau yooj yim dua thiab ntau yam rau ntau yam kev siv, tab sis nws yog ib qho tseem ceeb uas yuav tsum ua tib zoo xav txog cov khoom hnyav thiab HPMC, nrog rau txoj kev sib tov thiab lwm yam tshuaj ntxiv lossis cov khoom xyaw.Los ntawm kev xaiv cov kuab tshuaj uas tsim nyog thiab ua raws li cov kev coj ua zoo tshaj plaws rau kev sib xyaw thiab kev sim, nws muaj peev xwm ua tiav qhov zoo tshaj plaws solubility thiab cov khoom rau ntau yam ntawm HPMC-based khoom.