HPMC solubility mune organic solvents

Hydroxypropyl methylcellulose (HPMC) i polymer inonyungudika nemvura inowanzoshandiswa mumaindasitiri akasiyana siyana, kusanganisira kuvaka, mishonga, uye kugadzira chikafu.Nekudaro, HPMC inogona zvakare kunyungudika mune mamwe organic zvinonyungudutsa, izvo zvinogona kupa kumwe kuchinjika uye kuita kwakasiyana-siyana kwekushandisa kwakasiyana.

Kunyungudika kweHPMC muorganic solvents kunoenderana nezvinhu zvakasiyana, zvinosanganisira huremu hwemamorekuru epolymer, dhigirii rekutsiviwa kwemapoka ehydroxypropyl nemamethyl, uye polarity uye hydrogen-bonding zvivakwa zvezvinonyungudutsa.Kazhinji, HPMC ine huremu hwemamorekuru hwepamusoro uye dhigirii rekutsiva ichave yakaderera solubility muorganic solvents.Kusiyana neizvi, zvinonyungudutsa zvine polarity yakakwira uye yakasimba hydrogen bonding zvivakwa zvichave nekunyungudika kukuru.

Zvimwe zvakajairika organic zvinonyungudutsa zvinogona kunyungudutsa HPMC zvinosanganisira methanol, ethanol, isopropanol, acetone, uye ethyl acetate.Methanol uye ethanol ndiwo anonyanya kushandiswa zvinonyungudutsa zveHPMC, uye anogona kunyungudutsa HPMC muzvikamu zvinotangira pa5-10% nekurema.Isopropanol inogona kunyungudutsa HPMC muzvikamu zvinosvika 20% nehuremu, nepo acetone uye ethyl acetate inogona kunyungudutsa HPMC muhuwandu hunosvika 5% nehuremu.

Kunyungudika kweHPMC mune organic solvents kunogona kukanganiswa nehuwandu hwezvinhu, kusanganisira tembiricha yezvinonyungudutsa, nzira yekusanganisa, uye kuvapo kwezvimwe zvinowedzera kana zvigadzirwa.Kazhinji, kuwedzera tembiricha yekunyungudutsa kunogona kuwedzera kunyungudika kweHPMC, kunyangwe tembiricha isingafanire kunge yakakwira zvekuti ikonzere kuparara kana kuparara kwepolymer.Mukuwedzera, dzimwe nzira dzekusanganisa, dzakadai se ultrasonic kana magnetic kubvongodza, dzinogona kuwedzera kunyunguduka kweHPMC nekusimudzira kupararira kuri nani uye kugovera kwepolymer mune solvent.

Iyo solubility yeHPMC mune organic solvents inogona zvakare kukanganiswa nekuvapo kwezvimwe zvinowedzera kana zvinongedzo.Semuyenzaniso, ma surfactants kana cosolvents anogona kushandiswa kuvandudza kunyungudika kweHPMC mune mamwe organic solvents, kana kugadzirisa zvimiro zvechigadzirwa chekupedzisira.Nekudaro, zvakakosha kuti unyatso kuyedza izvi zvinowedzera kuti uone kuti hazvikanganise kunyungudika kana zvivakwa zveHPMC nenzira dzisingatarisirwe.

Imwe yakakosha yekutarisisa kana uchishandisa HPMC mune organic zvinonyungudutsa ndiyo mukana wekuparadzanisa chikamu kana kunaya kwepolymer.Izvi zvinogona kuitika kana kuwanda kweHPMC mune solvent kwakanyanyisa, kana kana iyo solvent isingaenderane neHPMC.Pamusoro pezvo, zvimwe zvinonyungudutsa zvinogona kuita kuti HPMC iumbe majirosi kana zvimwe zvinhu zvakasimba, izvo zvinogona kubatsira kune mamwe maapplication asi zvingave zvisingadiwe kune vamwe.

Mukupedzisa, iyo solubility yeHPMC mune organic solvents inogona kupa kuwedzera kuchinjika uye kuita kwakasiyana-siyana kune akasiyana maapplication, asi zvakakosha kuti titarise zvakanyanya maitiro eiyo solvent uye HPMC, pamwe nenzira yekusanganisa uye chero zvimwe zvinowedzera kana zvigadzirwa.Nekusarudza iyo inonyungudutsa yakakodzera uye nekutevera akanakisa maitiro ekusanganisa uye kuyedzwa, zvinokwanisika kuwana yakakwana solubility uye zvivakwa zveyakasiyana siyana yeHPMC-yakavakirwa zvigadzirwa.