HPMC solubility na organic solvents

Hydroxypropyl methylcellulose (HPMC) bụ polymer soluble mmiri nke a na-ejikarị na ụlọ ọrụ dị iche iche, gụnyere ihe owuwu, ọgwụ na mmepụta nri.Otú ọ dị, HPMC nwekwara ike agbaze na ụfọdụ organic solvents, nke nwere ike inye ọzọ mgbanwe na versatility maka dị iche iche ngwa.

The solubility nke HPMC na organic solvents na-adabere n'ụdị dị iche iche, gụnyere molekụla arọ nke polymer, ogo nnọchi nke hydroxypropyl na methyl otu, na polarity na hydrogen-bonding Njirimara nke ihe mgbaze.N'ozuzu, HPMC nwere ibu molekụla dị elu na ogo nke nnọchi ga-enwe obere solubility na ihe mgbaze organic.N'ụzọ dị iche, ihe mgbaze nwere polarity dị elu yana ihe njikọ njikọ hydrogen siri ike ga-enwe oke solubility.

Ụfọdụ ihe mgbaze organic nkịtị nwere ike igbari HPMC gụnyere methanol, ethanol, isopropanol, acetone, na ethyl acetate.Methanol na ethanol bụ ihe mgbaze a na-ejikarị eme ihe maka HPMC, na ha nwere ike igbari HPMC na mkpokọta sitere na 5-10% site na ibu.Isopropanol nwere ike igbari HPMC na ntinye aka ruru 20% site na ibu, ebe acetone na ethyl acetate nwere ike igbari HPMC na mkpokọta ruru 5% site na ibu.

Solubility nke HPMC na organic solvents nwere ike imetụta ọtụtụ ihe, gụnyere okpomọkụ nke ihe mgbaze, usoro nke ịgwakọta, na ọnụnọ nke ọzọ mgbakwunye ma ọ bụ Efrata.N'ozuzu, ịba ụba okpomọkụ nke ihe mgbaze nwere ike ịbawanye solubility nke HPMC, ọ bụ ezie na okpomọkụ ekwesịghị ịdị elu nke na-eme ka mmebi ma ọ bụ decomposition nke polymer.Na mgbakwunye, ụfọdụ ụzọ nke ịgwakọta, dị ka ultrasonic ma ọ bụ magnetik akpali akpali, nwere ike welie solubility nke HPMC site n'ịkwalite mma dispersion na nkesa nke polima na mgbaze.

Solubility nke HPMC na organic solvents nwekwara ike na-emetụta ọnụnọ nke ndị ọzọ mgbakwunye ma ọ bụ Efrata.Dịka ọmụmaatụ, enwere ike iji surfactants ma ọ bụ cosolvents iji melite solubility nke HPMC na ụfọdụ ihe mgbaze organic, ma ọ bụ iji dozie njirimara nke ngwaahịa ikpeazụ.Agbanyeghị, ọ dị mkpa iji nlezianya nwalee mgbakwunye ndị a iji hụ na ha anaghị egbochi ike ma ọ bụ ihe onwunwe nke HPMC n'ụzọ ndị a na-atụghị anya ya.

Otu echiche dị mkpa mgbe ị na-eji HPMC na ihe mgbaze organic bụ ikike nkewa nkewa ma ọ bụ ọdịda nke polymer.Nke a nwere ike ime ma ọ bụrụ na ntinye nke HPMC na ihe mgbaze dị oke elu, ma ọ bụ ma ọ bụrụ na ihe mgbaze adịghị adaba na HPMC.Na mgbakwunye, ụfọdụ ihe mgbaze nwere ike ime ka HPMC mepụta gels ma ọ bụ ihe ndị ọzọ siri ike, nke nwere ike ịba uru maka ụfọdụ ngwa mana ọ gaghị adị mma maka ndị ọzọ.

Na mmechi, solubility nke HPMC na organic solvents nwere ike inye ọzọ mgbanwe na versatility maka dị iche iche ngwa, ma ọ dị mkpa iji nlezianya tụlee Njirimara nke ihe mgbaze na HPMC, nakwa dị ka usoro nke ịgwakọta na ihe ọ bụla ọzọ mgbakwunye ma ọ bụ Efrata.Site n'ịhọrọ ihe mgbaze kwesịrị ekwesị na ịgbaso usoro kachasị mma maka ịgwakọta na ịnwale, ọ ga-ekwe omume nweta ezigbo solubility na ihe onwunwe maka ọtụtụ ngwaahịa dabeere na HPMC.