Mokhoa oa Tlhahiso ea Phase ea Mokelikeli oa ho Hlahisa Hydroxypropyl Methyl Cellulose (HPMC)

Hydroxypropyl methyl cellulose (HPMC) ke cellulose ether e sebelisoang haholo lits'ebetsong tse fapaneng tsa indasteri le tsa meriana ka lebaka la thepa ea eona e ntle ea 'mele le ea lik'hemik'hale.HPMC hangata e hlahisoa ka mekhoa e fapaneng, ho kenyeletsoa mokhoa oa tlhahiso ea mokelikeli.

Mokhoa oa tlhahiso ea mokelikeli ke mokhoa oa ho itšoara ka lik'hemik'hale o kenyelletsang karabelo ea methyl cellulose (MC) le propylene oxide (PO) ebe ka propylene glycol (PG) tlas'a maemo a itseng.Tshebetso ena e kenyelletsa mehato e latelang:

1. Tokisetso ea Methyl Cellulose (MC)

MC e fumanoa ka ho alafa selulose ka alkali ebe ka methylating ka methyl chloride.The degree of substitution (DS) ea MC e etsa qeto ea thepa ea eona mme e ka laoloa ka ho fapanyetsana maemo a karabelo.

2. Ho lokisoa ha Propylene Oxide (PO)

PO e lokiselitsoe ke oxidation ea propylene e sebelisang moea kapa oksijene ka pel'a mokelikeli.Boitšoaro bo etsoa ka mocheso o phahameng le likhatello ho etsa bonnete ba hore ho na le chai e ngata ea PO.

3. Karabelo ea MC le PO

Boitšoaro ba MC le PO bo etsoa ka pel'a motsoako le motsoako o kang toluene kapa dichloromethane.Phello ke exothermic 'me e hlahisa mocheso, o lokelang ho laoloa ho qoba liketso tse ka balehang.

4. Ho lokisoa ha Propylene Glycol (PG)

PG e lokiselitsoe ke hydrolysis ea propylene oxide e sebelisa metsi kapa acid e loketseng kapa catalyst ea motheo.Boitšoaro bo etsoa tlas'a maemo a bonolo ho fumana chai e ngata ea PG.

5. Maikutlo a MC-PO le PG

Sehlahisoa sa MC-PO se sebetsanoa le PG ka pel'a ntho e thusang le mokelikeli o kang ethanol kapa methanol.Phetoho ena e boetse ke exothermic 'me e baka mocheso, o lokelang ho laoloa ho qoba liketso tse ka balehang.

6. Ho hlatsoa le ho Omisa

Kamora karabelo, sehlahisoa se hlatsuoa ka metsi ebe se omisoa ho fumana HPMC.Hangata sehlahisoa se hloekisoa ho sebelisoa letoto la mehato ea ho hloekisa le ea centrifugation ho tlosa litšila leha e le life.

Mokhoa oa tlhahiso ea mokelikeli o na le melemo e 'maloa ho feta mekhoa e meng, ho kenyelletsa le chai e ngata, theko e tlase, le scalability e bonolo.Karabelo e ka etsoa ka sekepe se le seng, ho fokotsa tlhokahalo ea lisebelisoa tse rarahaneng le mekhoa.

Leha ho le joalo, mokhoa oa tlhahiso ea mokelikeli o boetse o na le mathata.Boitšoaro bo ka hlahisa mocheso, o lokelang ho laoloa ka hloko ho qoba litaba tsa polokeho.Tšebeliso ea lihlapolli le eona e ka baka likotsi tsa tikoloho le bophelo bo botle, ’me mokhoa oa ho hloekisa o ka nka nako le ho bitsa chelete e ngata.

Qetellong, mokhoa oa tlhahiso ea mokelikeli ke mokhoa o sebelisoang haholo bakeng sa ho hlahisa HPMC.Mokhoa ona o kenyelletsa karabelo ea MC le PO le PG tlasa maemo a itseng, e lateloe ke tlhoekiso le ho omisa.Le hoja mokhoa ona o na le litšitiso tse itseng, melemo ea oona e etsa hore e be khetho e ratoang bakeng sa likopo tsa indasteri le tsa meriana.