Hanyar Samar da Liquid-lokaci na Samar da Hydroxypropyl Methyl Cellulose (HPMC)

Hydroxypropyl methyl cellulose (HPMC) ne cellulose ether yadu amfani a daban-daban masana'antu da kuma Pharmaceutical aikace-aikace saboda da kyau kwarai jiki da kuma sinadaran Properties.HPMC yawanci ana samarwa ta hanyoyi daban-daban, gami da hanyar samar da ruwa-lokaci.

Hanyar samar da ruwa-lokaci shine tsarin amsawar sinadarai wanda ya ƙunshi amsawar methyl cellulose (MC) tare da propylene oxide (PO) sannan tare da propylene glycol (PG) a ƙarƙashin wasu yanayi.Tsarin ya ƙunshi matakai masu zuwa:

1. Shiri na Methyl Cellulose (MC)

Ana samun MC ta hanyar magance cellulose tare da alkali sannan kuma methylating shi da methyl chloride.Matsayin maye gurbin (DS) na MC yana ƙayyade kaddarorin sa kuma ana iya sarrafa shi ta hanyar bambanta yanayin amsawa.

2. Shiri na Propylene Oxide (PO)

An shirya PO ta hanyar oxidation na propylene ta amfani da iska ko oxygen a gaban mai kara kuzari.Ana aiwatar da aikin a yanayin zafi da matsa lamba don tabbatar da yawan amfanin ƙasa na PO.

3. Amsa na MC tare da PO

Ana aiwatar da halayen MC tare da PO a gaban mai haɓakawa da sauran ƙarfi kamar toluene ko dichloromethane.Halin yana da exothermic kuma yana haifar da zafi, wanda dole ne a sarrafa shi don guje wa halayen gudu.

4. Shiri na Propylene Glycol (PG)

Ana shirya PG ta hanyar hydrolysis na propylene oxide ta amfani da ruwa ko mai dacewa acid ko tushe mai kara kuzari.Ana aiwatar da matakin a ƙarƙashin yanayi mai sauƙi don samun yawan amfanin ƙasa na PG.

5. Amsa na MC-PO tare da PG

Ana amsa samfurin MC-PO tare da PG a gaban mai kara kuzari da sauran ƙarfi kamar ethanol ko methanol.Har ila yau, abin da ya faru yana da exothermic kuma yana haifar da zafi, wanda dole ne a sarrafa shi don guje wa halayen gudu.

6. Wanka da bushewa

Bayan amsawa, ana wanke samfurin da ruwa kuma a bushe don samun HPMC.Yawanci ana tsarkake samfurin ta amfani da jerin matakan tacewa da centrifugation don cire duk wani ƙazanta.

Hanyar samar da ruwa-lokaci tana da fa'idodi da yawa akan wasu hanyoyin, gami da yawan amfanin ƙasa, ƙarancin farashi, da sauƙin ƙima.Ana iya aiwatar da martani a cikin jirgi ɗaya, rage buƙatar kayan aiki masu rikitarwa da matakai.

Koyaya, hanyar samar da ruwa-lokaci shima yana da wasu kurakurai.Halin zai iya haifar da zafi, wanda dole ne a kula da shi a hankali don kauce wa matsalolin tsaro.Hakanan amfani da kaushi na iya haifar da haɗarin muhalli da lafiya, kuma tsarin tsarkakewa na iya ɗaukar lokaci da tsada.

A ƙarshe, hanyar samar da ruwa-lokaci hanya ce da ake amfani da ita sosai don samar da HPMC.Hanyar ta ƙunshi amsawar MC tare da PO da PG a ƙarƙashin wasu yanayi, sannan tsarkakewa da bushewa.Yayin da hanyar tana da wasu kurakurai, fa'idodinta sun sa ya zama sanannen zaɓi don aikace-aikacen masana'antu da magunguna.