IHydroxypropylmethylcellulose (HPMC) iyipolymer ethandwayo esetshenziswa ezimbonini ezifana nemithi, ezokwakha, ukudla nokunakekela komuntu siqu.Kuyindlela eguquliwe ye-cellulose etholwe ngokuphendula i-methylcellulose nge-propylene oxide.I-HPMC iyimpushana emhlophe noma emhlophe, engenaphunga, enganambitheki, encibilika kalula emanzini, i-ethanol nezinye izincibilikisi eziphilayo.Leli phepha lixoxa ngezinkomba zobuchwepheshe eziyinhloko ze-HPMC.
i-viscosity
I-Viscosity iyinkomba yezobuchwepheshe ebaluleke kakhulu ye-HPMC, enquma ukuziphatha kwayo nokusetshenziswa kwayo ezimbonini ezihlukahlukene.I-HPMC ine-viscosity ephezulu, okusho ukuthi inokuthungwa okuminyene, okufana noju.I-viscosity ye-HPMC ingalungiswa ngokushintsha izinga lokushintshwa kwamaqembu e-hydroxyl.Lapho izinga lokushintsha liphakeme, i-viscosity iyanda.
Izinga lokushintsha
I-degree of substitution (DS) ingenye inkomba yezobuchwepheshe ebalulekile ye-HPMC, ebhekisela enanini lamaqembu e-hydroxyl esikhundleni samaqembu e-hydroxypropyl namaqembu e-methyl.I-DS ye-HPMC ngokuvamile isukela ku-0.1 kuye ku-1.7, nge-DS ephakeme ebonisa ukuguqulwa okukhulu.I-DS ye-HPMC ithinta ukuncibilika kwayo, i-viscosity kanye nezakhiwo zejeli.
isisindo samangqamuzana
Isisindo samangqamuzana e-HPMC futhi siyinkomba yezobuchwepheshe ebalulekile ethinta izakhiwo zayo ezingokomzimba namakhemikhali njengokuncibilika, i-viscosity, kanye ne-gelation.I-HPMC ivamise ukuba nesisindo sengqamuzana esingu-10,000 kuya ku-1,000,000 wama-Daltons, anesisindo samangqamuzana aphezulu abonisa amaketanga amade e-polymer.Isisindo samangqamuzana e-HPMC sithinta ukusebenza kahle kwayo kokuqina, amandla okwenza ifilimu kanye namandla okubamba amanzi.
PH inani
Inani le-pH le-HPMC liyinkomba ebalulekile yezobuchwepheshe ethinta ukunyibilika kwayo kanye nokubonakala kwayo.I-HPMC iyancibilika ezixazululweni ezine-asidi ne-alkaline, kodwa i-viscosity yayo iphezulu ngaphansi kwezimo ezine-asidi.I-pH ye-HPMC ingalungiswa ngokungeza i-asidi noma isisekelo.I-HPMC ngokuvamile ine-pH ephakathi kuka-4 no-9.
umswakama
Umswakamo we-HPMC uyinkomba yezobuchwepheshe ebalulekile ethinta ukuzinza kwesitoreji nokusebenza kwayo.I-HPMC iyi-hygroscopic, okusho ukuthi imunca umswakama ovela emoyeni.Umswakama we-HPMC kufanele ugcinwe ungaphansi kuka-7% ukuze kuqinisekiswe ukuzinza kanye nekhwalithi yayo.Umswakama ophezulu ungaholela ekukhoneni kwe-polymer, i-clumping kanye nokuwohloka.
Okuqukethwe komlotha
Okuqukethwe komlotha we-HPMC kuyinkomba ebalulekile yezobuchwepheshe ethinta ubumsulwa nekhwalithi yayo.Umlotha ubhekisela ensaleni ye-inorganic esele ngemva kokushiswa kwe-HPMC.Okuqukethwe komlotha we-HPMC kufanele kube ngaphansi kuka-7% ukuze kuqinisekiswe ubumsulwa nekhwalithi yayo.Umlotha omningi ungase ubonise ukuba khona kokungcola noma ukungcola ku-polymer.
Izinga lokushisa le-Gelation
Izinga lokushisa lejeli le-HPMC liyinkomba ebalulekile yezobuchwepheshe ethinta ukusebenza kwayo kwejeli.I-HPMC ingangena ngaphansi kwezimo ezithile zokushisa nezimo zokuhlushwa.Izinga lokushisa le-gelation le-HPMC lingashintshwa ngokushintsha izinga lokushintshwa kanye nesisindo samangqamuzana.Izinga lokushisa le-gelling le-HPMC livamise ukuba ngu-50 kuya ku-90°C.
Ekuphetheni
IHydroxypropylmethylcellulose (HPMC) iyi-polymer esebenza ngezinto eziningi enezinhlobonhlobo zokucaciswa.Izinkomba zobuchwepheshe eziyinhloko ze-HPMC zifaka i-viscosity, izinga lokushintsha, isisindo samangqamuzana, inani le-pH, okuqukethwe komlotha, okuqukethwe komlotha, izinga lokushisa le-gelation, njll. Lezi zinkomba zobuchwepheshe zithinta izakhiwo zomzimba namakhemikhali e-HPMC futhi zinquma ukusebenza kwayo ezimbonini ezihlukahlukene.Ngokwazi lokhu kucaciswa, singakhetha uhlobo olulungile lwe-HPMC kuhlelo lwethu lokusebenza oluthile futhi siqinisekise ikhwalithi yayo nokuzinza.
Isikhathi sokuthumela: Sep-04-2023