Hydroxypropylmethylcellulose (HPMC) ke polymer e tsebahalang e sebelisoang liindastering tse kang meriana, kaho, lijo le tlhokomelo ea botho.Ke mofuta o fetotsoeng oa selulose o fumanoang ka ho arabela methylcellulose ka propylene oxide.HPMC ke phofo e tšoeu kapa e bosoeu, e sa nkheng, e sa latsoeheng, e qhibilihang habonolo ka metsing, ethanol le lihlapolli tse ling tsa tlhaho.Pampiri ena e bua ka matšoao a mantlha a tekheniki a HPMC.
viscosity
Viscosity ke index ea bohlokoa ka ho fetisisa ea tekheniki ea HPMC, e khethollang boitšoaro ba eona le ts'ebeliso ea eona liindastering tse fapaneng.HPMC e na le viscosity e phahameng, ho bolelang hore e na le sebopeho se teteaneng, se kang mahe a linotši.The viscosity ea HPMC e ka fetoloa ka ho fetola tekanyo ea ho kenya sebaka sa lihlopha tsa hydroxyl.Ha tekanyo ea ho nkela sebaka e phahame, e phahamisa viscosity.
Boemo ba ho nka sebaka
The degree of substitution (DS) ke sesupo se seng sa bohlokoa sa tekheniki sa HPMC, se bolelang palo ea lihlopha tsa hydroxyl tse nkeloang sebaka ke lihlopha tsa hydroxypropyl le lihlopha tsa methyl.DS ea HPMC hangata e tloha ho 0.1 ho isa ho 1.7, 'me DS e phahameng e bonts'a phetoho e kholoanyane.DS ea HPMC e ama ho solubility, viscosity le thepa ea gel.
boima ba molek'hule
Boima ba limolek'hule tsa HPMC hape ke index ea bohlokoa ea tekheniki e amang thepa ea eona ea 'mele le ea lik'hemik'hale joalo ka solubility, viscosity, le gelation.HPMC hangata e na le boima ba molek'hule ho tloha ho 10,000 ho isa ho 1,000,000 Daltons, e nang le litekanyo tse phahameng tsa limolek'hule tse bontšang liketane tse telele tsa polymer.Boima ba limolek'hule tsa HPMC bo ama ts'ebetso ea eona e matla, bokhoni ba ho etsa filimi le matla a ho boloka metsi.
PH boleng
Boleng ba pH ba HPMC ke index ea bohlokoa ea tekheniki e amang ho solubility le viscosity ea eona.HPMC e qhibiliha ka litharollo tsa asiti le alkaline, empa viscosity ea eona e phahame ka tlas'a maemo a asiti.PH ea HPMC e ka fetoloa ka ho eketsa asiti kapa setsi.HPMC hangata e na le pH lipakeng tsa 4 le 9.
mongobo
Mongobo oa HPMC ke index ea bohlokoa ea tekheniki e amang botsitso ba polokelo le ts'ebetso ea ts'ebetso.HPMC ke hygroscopic, e bolelang hore e monya mongobo moeeng.Mongobo oa HPMC o lokela ho bolokoa ka tlase ho 7% ho netefatsa botsitso le boleng ba eona.Mongobo o phahameng o ka lebisa ho polima caking, clumping le ho senyeha.
Likahare tsa molora
Likahare tsa molora tsa HPMC ke index ea bohlokoa ea tekheniki e amang bohloeki le boleng ba eona.Molora o bolela masalla a inorganic a setseng ka mor'a hore HPMC e chesoe.Likahare tsa molora tsa HPMC li lokela ho ba ka tlase ho 7% ho netefatsa bohloeki le boleng ba eona.Molora o phahameng o ka bontša boteng ba litšila kapa tšilafalo ho polymer.
Mocheso oa mocheso
Thempereichara ea gel ea HPMC ke index ea bohlokoa ea tekheniki e amang ts'ebetso ea eona ea gel.HPMC ka gel tlas'a mocheso itseng le maemo a mahloriso.Mocheso oa mocheso oa HPMC o ka fetoloa ka ho fetola tekanyo ea ho fetola le boima ba limolek'hule.Thempereichara ea gelling ea HPMC hangata ke 50 ho isa ho 90°C.
ha re phethela
Hydroxypropylmethylcellulose (HPMC) ke polymer e sebetsang ka bongata e nang le mefuta e mengata ea litlhaloso.Lipontšo tse ka sehloohong tsa tekheniki tsa HPMC li kenyelletsa viscosity, tekanyo ea ho fetola, boima ba limolek'hule, boleng ba pH, mongobo, dikahare tsa molora, mocheso oa gelation, joalo-joalo matšoao ana a botekgeniki a ama thepa ea 'mele le lik'hemik'hale tsa HPMC le ho etsa qeto ea hore na e sebetsa joang liindastering tse sa tšoaneng.Ka ho tseba litlhaloso tsena, re ka khetha mofuta o nepahetseng oa HPMC bakeng sa ts'ebeliso ea rona e ikhethileng mme ra netefatsa boleng ba eona le botsitso.
Nako ea poso: Sep-04-2023