IHydroxypropylmethylcellulose (HPMC) yipolymer eyaziwayo esetyenziswa kumashishini afana namayeza, ukwakhiwa, ukutya kunye nokhathalelo lomntu.Yindlela eguqulweyo ye-cellulose efunyenwe ngokuphendula i-methylcellulose kunye nepropylene oxide.I-HPMC ngumgubo omhlophe okanye omhlophe, ongenavumba, ongenancasa, onyibilika ngokulula emanzini, ethanol kunye nezinye izinyibilikisi eziphilayo.Eli phepha lixoxa ngezona zalathisi zobugcisa ze-HPMC.
i-viscosity
I-Viscosity yeyona nto ibalulekileyo yesalathiso sobugcisa be-HPMC, emisela indlela yokuziphatha kwayo kunye nokusetyenziswa kumashishini ahlukeneyo.I-HPMC ine-viscosity ephezulu, ethetha ukuba inobunzima obufana nobusi.I-viscosity ye-HPMC inokulungiswa ngokutshintsha iqondo lokutshintshwa kwamaqela e-hydroxyl.Iqondo eliphezulu lokutshintshwa, liphezulu i-viscosity.
Iqondo lokutshintsha
Iqondo lokuthatha indawo (DS) sesinye isalathisi sobugcisa esibalulekileyo se-HPMC, esibhekisa kwinani lamaqela e-hydroxyl endaweni yawo ngamaqela e-hydroxypropyl kunye namaqela e-methyl.I-DS ye-HPMC iqhelekile ukusuka kwi-0.1 ukuya kwi-1.7, kunye ne-DS ephezulu ebonisa ukuguqulwa okukhulu.I-DS ye-HPMC ichaphazela ukunyibilika kwayo, i-viscosity kunye neempawu zejeli.
ubunzima bemolekyuli
Ubunzima bemolekyuli ye-HPMC kwakhona isalathiso esibalulekileyo sobugcisa esichaphazela iipropati zayo zomzimba kunye neekhemikhali ezifana nokunyibilika, i-viscosity, kunye ne-gelation.I-HPMC idla ngokuba nobunzima bemolekyuli obuyi-10,000 ukuya kwi-1,000,000 yeeDaltons, ezinobunzima obuphezulu bemolekyuli obubonisa amatyathanga epolymer amade.Ubunzima bemolekyuli ye-HPMC buchaphazela ukusebenza kakuhle kwayo, ukukwazi ukwenza ifilimu kunye nomthamo wokubamba amanzi.
PH ixabiso
Ixabiso le-pH le-HPMC lisalathiso esibalulekileyo sobugcisa esichaphazela ukunyibilika kwayo kunye ne-viscosity.I-HPMC iyanyibilika kwizisombululo ze-acidic kunye ne-alkaline, kodwa i-viscosity yayo iphezulu phantsi kweemeko ze-acidic.I-pH ye-HPMC inokuhlengahlengiswa ngokudibanisa i-asidi okanye isiseko.I-HPMC ine-pH phakathi kwe-4 kunye ne-9.
umxholo wokufuma
Isiqulatho sokufuma se-HPMC sisalathiso esibalulekileyo sobugcisa esichaphazela ukuzinza kwayo kokugcinwa kunye nokusebenza kokucubungula.I-HPMC yi-hygroscopic, nto leyo ethetha ukuba ifunxa ukufuma emoyeni.Isiqulatho sokufuma se-HPMC kufuneka sigcinwe ngaphantsi kwe-7% ukuqinisekisa uzinzo kunye nomgangatho wayo.Ukufuma okuphezulu kunokukhokelela kwi-polymer caking, i-clumping kunye nokuthotywa.
Umxholo wothuthu
Umxholo wothuthu lwe-HPMC sisalathiso esibalulekileyo sobugcisa esichaphazela ubunyulu kunye nomgangatho.Umlotha ubhekisa kwintsalela ye-inorganic eshiywe emva kokuba i-HPMC itshisiwe.Umxholo wothuthu lwe-HPMC kufuneka ube ngaphantsi kwe-7% ukuqinisekisa ukucoceka kunye nomgangatho.Umxholo omlotha ophezulu unokubonisa ubukho bokungcola okanye ukungcola kwipolymer.
Ubushushu beGelation
Ubushushu bejeli ye-HPMC sisalathiso esibalulekileyo sobugcisa esichaphazela ukusebenza kwayo kwejeli.I-HPMC inokwenza ijeli phantsi kobushushu obuthile kunye neemeko zoxinaniso.Ubushushu be-gelation ye-HPMC inokuhlengahlengiswa ngokutshintsha iqondo lokuthatha indawo kunye nobunzima bemolekyuli.Ubushushu be-gelling ye-HPMC buqhele ukuba ngama-50 ukuya kuma-90°C.
ukuququmbela
I-Hydroxypropylmethylcellulose (HPMC) i-polymer esebenza ngeendlela ezininzi ezinoluhlu olubanzi lweenkcukacha.Iimpawu eziphambili zobugcisa ze-HPMC ziquka i-viscosity, i-degree of substitution, ubunzima be-molecular, ixabiso le-pH, umxholo wokufuma, umxholo wothuthu, ubushushu be-gelation, njl. Ezi zalathisi zobugcisa zichaphazela iipropati zomzimba kunye neekhemikhali ze-HPMC kunye nokumisela ukusebenza kwayo kumashishini ahlukeneyo.Ngokwazi ezi nkcukacha, sinokukhetha uhlobo oluchanekileyo lwe-HPMC kwisicelo sethu esithile kwaye siqinisekise umgangatho kunye nokuzinza.
Ixesha lokuposa: Sep-04-2023