I-HPMC i-semi-synthetic polymer etholakala ku-cellulose.Ngenxa yokuqina kwayo okuhle kakhulu, ukuzinzisa kanye nezakhiwo zefilimu, isetshenziswa kakhulu kwezokwelapha, ukudla, izimonyo nezinye izimboni.Ukutadisha ukuziphatha kwayo kwe-viscosity kubalulekile ukuze kwandiswe ukusebenza kwayo ezinhlelweni ezahlukene.
1. Ukulinganiswa kwe-viscosity:
I-Rotational Viscometer: I-viscometer ejikelezayo ikala i-torque edingekayo ukuze uzungezise i-spindle ngesivinini esingaguquki lapho icwiliswa kusampula.Ngokushintsha i-geometry kanye nesivinini sokujikeleza kwe-spindle, i-viscosity kumazinga ahlukahlukene wokugunda inganqunywa.Le ndlela yenza ukubonakaliswa kwe-viscosity ye-HPMC ngaphansi kwezimo ezahlukene.
I-Capillary Viscometer: I-capillary viscometer ikala ukugeleza koketshezi ngeshubhu le-capillary ngaphansi kwethonya lamandla adonsela phansi noma ingcindezi.Isixazululo se-HPMC siphoqelelwa ngeshubhu le-capillary futhi i-viscosity ibalwa ngokusekelwe izinga lokugeleza kanye nokwehla kwengcindezi.Le ndlela ingasetshenziswa ukutadisha i-viscosity ye-HPMC ngamanani aphansi okugunda.
2.Isilinganiso se-Rheological:
I-Dynamic Shear Rheometry (DSR): I-DSR ikala impendulo yento ekugugelekeni okuguquguqukayo kwe-shear.Amasampula e-HPMC angaphansi kwengcindezi ye-shear oscillatory futhi izinhlobo eziwumphumela zalinganiswa.Ukuziphatha kwe-viscoelastic kwezixazululo ze-HPMC kungabonakala ngokuhlaziya i-viscosity eyinkimbinkimbi (η*) kanye nemodulus yesitoreji (G') kanye nemodulus yokulahlekelwa (G”).
Ukuhlolwa kokukhula nokululama: Lezi zivivinyo zibandakanya ukufaka amasampula e-HPMC ekucindezelekeni okungapheli noma ubunzima isikhathi eside (isigaba se-creep) bese kuqapha ukululama okulandelayo ngemva kokudalulwa kwengcindezi noma ubunzima.Ukuziphatha kokunyonyoba nokululama kunikeza ukuqonda ngezakhiwo ze-viscoelastic ze-HPMC, okuhlanganisa ukuguquguquka kwayo namandla okubuyisela.
3. Izifundo ezincike ekugxileni nezinga lokushisa:
I-Concentration Scan: Izilinganiso ze-Viscosity zenziwa phezu kwebanga lokugxila kwe-HPMC ukuze kufundwe ubudlelwano phakathi kwe-viscosity nokugxilisa kwe-polymer.Lokhu kusiza ukuqonda ukusebenza kahle kokuqina kwe-polymer nokuziphatha kwayo okuncike ekugxilweni kwayo.
Ukuskena kwezinga lokushisa: Izilinganiso ze-viscosity zenziwa emazingeni okushisa ahlukene ukuze kufundwe umthelela wezinga lokushisa ku-viscosity ye-HPMC.Ukuqonda ukuncika kwezinga lokushisa kubalulekile ezinhlelweni zokusebenza lapho ama-HPMC ethola khona izinguquko zezinga lokushisa, njengokwakheka kwemithi.
4. Ukuhlaziywa kwesisindo samangqamuzana:
I-Size Exclusion Chromatography (SEC): I-SEC ihlukanisa ama-molecule e-polymer ngokusekelwe kusayizi wawo esixazululweni.Ngokuhlaziya iphrofayili ye-elution, ukusatshalaliswa kwesisindo samangqamuzana esampula ye-HPMC kunganqunywa.Ukuqonda ubudlelwano phakathi kwesisindo samangqamuzana kanye ne-viscosity kubalulekile ekubikezeleni ukuziphatha kwe-rheological kwe-HPMC.
5. Ukumodela kanye Nokulingiswa:
Amamodeli wetiyori: Amamodeli etiyori ahlukahlukene, njengemodeli ye-Carreau-Yasuda, imodeli ye-Cross noma imodeli yomthetho wamandla, angasetshenziswa ukuchaza ukuziphatha kwe-viscosity kwe-HPMC ngaphansi kwezimo ezihlukene zokugunda.Lawa mamodeli ahlanganisa amapharamitha afana nesilinganiso se-shear, ukugxila, nesisindo samangqamuzana ukubikezela ngokunembile i-viscosity.
Ukulingisa Kwekhompyutha: Ukulingiswa kweComputational Fluid Dynamics (CFD) kunikeza ukuqonda ngokuziphatha kokugeleza kwezixazululo ze-HPMC kumajiyometri ayinkimbinkimbi.Ngokuxazulula izibalo ezibusayo zokugeleza koketshezi, ukulingisa kwe-CFD kungabikezela ukusatshalaliswa kwe-viscosity namaphethini okugeleza ngaphansi kwezimo ezihlukene.
6. Izifundo ze-in situ ne-in vitro:
Izilinganiso ze-in-situ: Amasu e-in-situ abandakanya ukufunda izinguquko ze-viscosity zesikhathi sangempela endaweni ethile noma isicelo.Isibonelo, ekwenziweni kwemithi, izilinganiso ze-situ zingaqapha izinguquko ze-viscosity ngesikhathi sokuhlakazeka kwethebhulethi noma ukusetshenziswa kwejeli ye-topical.
Ukuhlolwa kwe-in vitro: Ukuhlolwa kwe-in vitro kulingisa izimo zomzimba ukuze kuhlolwe ukuziphatha kwe-viscosity kokubunjwa okususelwe ku-HPMC okuhloselwe ukuphatha ngomlomo, amehlo, noma i-topical.Lezi zivivinyo zinikeza ulwazi olubalulekile ekusebenzeni nasekuzinzeni kokwakheka ngaphansi kwezimo zebhayoloji ezifanele.
7.Ubuchwepheshe obuthuthukisiwe:
I-Microrheology: Amasu e-Microrheology, afana nokusabalalisa ukukhanya okunamandla (DLS) noma i-particle tracking microrheology (PTM), avumela ukuhlola izici ze-viscoelastic zoketshezi oluyinkimbinkimbi esikalini esincane.Lawa masu anganikeza imininingwane ngokuziphatha kwe-HPMC ezingeni lamangqamuzana, agcwalise izilinganiso ze-rheological macroscopic.
I-Nuclear Magnetic Resonance (NMR) Spectroscopy: I-NMR spectroscopy ingasetshenziswa ukutadisha amandla e-molecular dynamics kanye nokusebenzisana kwe-HPMC ekuxazululeni.Ngokuqapha amashifu amakhemikhali nezikhathi zokuphumula, i-NMR inikeza ulwazi olubalulekile mayelana nezinguquko zokuvumelana kwe-HPMC kanye nokusebenzisana kwe-polymer-solvent ethinta i-viscosity.
Ukutadisha ukuziphatha kwe-viscosity ye-HPMC kudinga indlela ye-multidisciplinary, okuhlanganisa amasu okuhlola, ukumodela kwethiyori, nezindlela zokuhlaziya ezithuthukile.Ngokusebenzisa inhlanganisela ye-viscometry, i-rheometry, ukuhlaziywa kwamangqamuzana, ukumodela, namasu athuthukile, abacwaningi bangathola ukuqonda okuphelele kwezakhiwo ze-rheological ze-HPMC futhi bandise ukusebenza kwayo ezinhlelweni ezihlukahlukene.
Isikhathi sokuthumela: Feb-29-2024