HPMC shine polymer Semi-Synthetic wanda aka samo daga cellulose.Saboda kyawawan kauri, ƙarfafawa da ƙirƙirar kayan fim, ana amfani dashi sosai a cikin magunguna, abinci, kayan kwalliya da sauran masana'antu.Nazarin halayen danko yana da mahimmanci don inganta aikin sa a aikace-aikace daban-daban.
1. Ma'aunin danko:
Viscometer Rotational: Viscometer na jujjuya yana auna ƙarfin ƙarfin da ake buƙata don jujjuya igiya a madaidaicin gudu lokacin da aka nutsar da shi cikin samfur.Ta hanyar bambanta juzu'i da saurin jujjuyawa na sandal, za'a iya tantance danko a nau'ikan juzu'i daban-daban.Wannan hanya tana ba da damar halayyar ɗankowar HPMC a ƙarƙashin yanayi daban-daban.
Capillary Viscometer: A capillary viscometer yana auna magudanar ruwa ta bututun capillary ƙarƙashin rinjayar nauyi ko matsa lamba.Ana tilasta maganin HPMC ta cikin bututun capillary kuma an ƙididdige danko bisa ga yawan kwarara da matsa lamba.Ana iya amfani da wannan hanyar don nazarin dankowar HPMC a ƙananan ƙimar ƙarfi.
2. Ma'aunin Rheological:
Dynamic Shear Rheometry (DSR): DSR tana auna martanin wani abu zuwa nakasar juzu'i mai ƙarfi.Samfurori na HPMC sun kasance suna fuskantar damuwa mai ƙarfi na oscillatory kuma an auna abubuwan da suka haifar.Halin viscoelastic na mafita na HPMC ana iya siffanta shi ta hanyar nazarin hadadden danko (η*) da ma'aunin ma'auni (G') da modulus asarar (G").
Gwaje-gwajen rarrafe da farfadowa: Waɗannan gwaje-gwajen sun haɗa da gabatar da samfuran HPMC zuwa matsananciyar damuwa ko damuwa na tsawon lokaci (lokacin raɗaɗi) sannan sa ido kan farfadowa na gaba bayan an sami sassauci ko damuwa.Halin rarrafe da farfadowa suna ba da haske game da kaddarorin viscoelastic na HPMC, gami da nakasar sa da ƙarfin dawo da shi.
3. Nazarin dogaro da hankali da zafin jiki:
Scan Na Tattaunawa: Ana yin ma'aunin danko sama da kewayon abubuwan tattarawar HPMC don nazarin alakar da ke tsakanin danko da tattarawar polymer.Wannan yana taimakawa wajen fahimtar ingancin kauri na polymer da halayen dogaro da hankali.
Binciken yanayin zafi: Ana yin ma'aunin danko a yanayin zafi daban-daban don nazarin tasirin zafin jiki akan dankowar HPMC.Fahimtar dogaro da zafin jiki yana da mahimmanci ga aikace-aikace inda HPMCs ke fuskantar canjin zafin jiki, kamar ƙirar magunguna.
4. Binciken nauyin kwayoyin halitta:
Girman Ware Chromatography (SEC): SEC yana raba kwayoyin polymer bisa girmansu a cikin bayani.Ta hanyar nazarin bayanin martaba, ana iya ƙaddara rarraba nauyin kwayoyin halitta na samfurin HPMC.Fahimtar dangantakar dake tsakanin nauyin kwayoyin halitta da danko yana da mahimmanci don tsinkayar halayen rheological na HPMC.
5. Samfura da Kwaikwayo:
Samfuran ka'idar: Za'a iya amfani da nau'ikan ka'idoji daban-daban, kamar samfurin Carreau-Yasuda, ƙirar giciye ko ƙirar doka, don bayyana ɗabi'ar ɗankowar HPMC ƙarƙashin yanayi daban-daban.Waɗannan samfuran suna haɗa sigogi kamar ƙimar ƙarfi, taro, da nauyin kwayoyin halitta don tsinkayar ɗanko daidai.
Kwamfuta Kwamfuta: Simulators na Fluid Dynamics (CFD) suna ba da haske game da yanayin kwararar mafita na HPMC a cikin rikitattun geometries.Ta hanyar ƙididdige ma'auni na gudanarwa na kwararar ruwa, simintin CFD na iya hasashen rarraba danko da tsarin gudana a ƙarƙashin yanayi daban-daban.
6. Karatun a wuri da in vitro:
Ma'auni na cikin-wuri: Dabarun cikin-wuri sun haɗa da nazarin canje-canje na ɗanko na ainihin lokaci a cikin takamaiman yanayi ko aikace-aikace.Misali, a cikin magungunan magunguna, ma'aunin wuri na iya sa ido kan sauye-sauyen danko yayin rarrabuwar kwamfutar hannu ko aikace-aikacen gel.
Gwajin In vitro: Gwajin In vitro yana daidaita yanayin yanayin jiki don kimanta halayen ɗankowar abubuwan tushen HPMC da aka yi niyya don gudanar da baki, ido, ko na zahiri.Waɗannan gwaje-gwajen suna ba da bayanai masu mahimmanci game da aiki da kwanciyar hankali na ƙira a ƙarƙashin yanayin ilimin halitta masu dacewa.
7.Babban fasaha:
Microrheology: Dabarun ƙwayoyin ƙwayoyin cuta, irin su watsawar haske mai ƙarfi (DLS) ko microrheology tracking barbashi (PTM), ba da damar bincikar abubuwan da ke tattare da hadaddun ruwaye a sikelin ƙarami.Waɗannan fasahohin na iya ba da haske game da halayen HPMC a matakin ƙwayoyin cuta, suna haɓaka ma'aunin rheological macroscopic.
Nukiliya Resonance Magnetic Resonance (NMR) Spectroscopy: NMR spectroscopy za a iya amfani da shi don nazarin ƙarfin kwayoyin halitta da hulɗar HPMC a cikin bayani.Ta hanyar sa ido kan sauye-sauyen sinadarai da lokutan shakatawa, NMR yana ba da bayanai masu mahimmanci akan canje-canjen yanayi na HPMC da ma'amalar polymer-kawar da ke shafar danko.
Nazarin halayen danko na HPMC yana buƙatar tsarin dabaru da yawa, gami da dabarun gwaji, ƙirar ƙira, da hanyoyin bincike na gaba.Ta hanyar amfani da haɗin viscometry, rheometry, nazarin kwayoyin halitta, ƙirar ƙira, da fasaha na ci gaba, masu bincike za su iya samun cikakkiyar fahimta game da kaddarorin rheological na HPMC kuma su inganta aikin sa a cikin aikace-aikace iri-iri.
Lokacin aikawa: Fabrairu-29-2024