I-HPMC isebenzisa kwezemithi
IHydroxypropyl methylcellulose (HPMC) iphuma ku-cellulose esetshenziswa kakhulu embonini yezemithi ngezakhiwo zayo ezihlukile. I-semi-synthetic, i-polymer encibilikayo emanzini, kanye ne-non-ionic engasetshenziswa njenge-thickener, binder, i-ejenti yokwakha ifilimu, kanye nokothambisa. I-HPMC isizuze ukuduma kwezemithi ngenxa yekhono layo lokuthuthukisa ikhwalithi nokuzinza kwamafomu omthamo.
Impahla | Incazelo |
---|---|
Isakhiwo samakhemikhali | I-semisynthetic cellulose derivative |
Isisindo samangqamuzana | 10,000-1,500,000 g/mol |
Izinga lokushintsha | 0.9-1.7 |
Ukuncibilika | Incibilika emanzini nasezincibilikisini eziningi eziphilayo |
ukuzinza kwe-pH | Izinzile phezu kwebanga le-pH elibanzi |
Ukuzinza okushisayo | Izinzile kufikela ku-200°C |
I-Viscosity | Ingasukela kokuphansi kuye phezulu kuye ngebanga |
Usayizi wezinhlayiya | I-100 mesh (150 microns) noma encane |
Ukubukeka | Impushana emhlophe ukuya kokumhlophe noma ama-granules |
Iphunga | Ayinaphunga |
Nambitha | Enganambitheki |
Ubuthi | Ayinabuthi futhi ayicunuli |
I-Allergenicity | Okungeyona i-allergenic |
Odla imifino/i-vegan | Abadla imifino kanye ne-vegan |
Kulesi sihloko, sizoxoxa ngokusetshenziswa okuhlukahlukene kwe-HPMC kwezemithi ngokuningiliziwe.
Ukwakhiwa Kwethebhulethi
I-HPMC ivamise ukusetshenziswa njengesihlanganisi ekwakhiweni kwethebhulethi. Isebenza njenge-ejenti ebophayo ngokuthuthukisa izici ezihlangene ze-tablet granules, okuholela kumaphilisi aqinile futhi angakwazi ukuwohloka. Ukwengeza, i-HPMC isetshenziswa njengesahlukanisi ekwakhiweni kwethebhulethi, ekhuthaza ukuhlakazeka kwethebhulethi nokuhlakazwa. I-HPMC ingasetshenziswa futhi njengento yokumboza amaphilisi, esiza ukuvikela umuthi endaweni, ukuthuthukisa ukuzinza, nokulawula ukukhululwa kwezidakamizwa.
Ukwakhiwa kweCapsule
I-HPMC isetshenziswa njenge-capsule material ekwenzeni amaphilisi e-gelatin aqinile nathambile. Ingenye ye-gelatin njengoba iyimifino, ayinabuthi, futhi ayiyona i-allergenic. Amaphilisi e-HPMC nawo azinze kakhulu kunamaphilisi e-gelatin, njengoba awahlushwa ukuxhumanisa nokushintsha umbala. Amaphilisi e-HPMC angenziwa ukuthi ancibilike esiswini noma emathunjini, kuye ngephrofayili yokukhululwa edingekayo yomuthi.
Ukwakhiwa Kwamehlo
I-HPMC isetshenziswa ekwakhiweni kwe-ophthalmic njengesithuthukisi se-viscosity, enikeza isikhathi sokuxhumana esengeziwe neso kanye nokukhululwa kwezidakamizwa isikhathi eside. Ibuye isetshenziswe njenge-lubricant, enciphisa ukucasuka futhi ithuthukise ukunethezeka kwesiguli.
Ukwakhiwa Kwezihloko
I-HPMC isetshenziswa ekwakhiweni kwezihloko njenge-ejenti yokujiya, ehlinzeka nge-viscosity nokuthungwa kokhilimu, amajeli, namaloshini. Kungase futhi kuthuthukise ukuzinza kokubunjwa ngokunciphisa i-synersis nokuvimbela ukuhlukaniswa kwesigaba.
Ukwakhiwa Kwabazali
I-HPMC isetshenziswa ekwakhiweni kwabazali njengesiqinisi nokujiya. Kuyasiza ukugcina ukuzinza ngokomzimba kokubunjwa, ukuvimbela ukuhlangana kwezinhlayiyana kanye ne-sedimentation. Ibuye isetshenziswe njenge-ejenti yokumisa izidakamizwa ezingancibiliki kahle, iqinisekisa ukusatshalaliswa okufanayo komuthi ekwakhiweni.
Ukwakhiwa Kokukhishwa Okulawulwayo
I-HPMC ijwayele ukusetshenziswa ekuthuthukisweni kokwakhiwa kokukhishwa okulawulwayo. Ingasetshenziswa njengento ye-matrix, ekhulula kancane kancane umuthi ngokuhamba kwesikhathi. I-HPMC ingase futhi isetshenziselwe ukuguqula izinga lokukhululwa kwezidakamizwa ngokushintsha ukugxiliswa kwe-polymer, isisindo samangqamuzana, kanye nezinga lokushintshwa.
Ukwakhiwa kwe-Mucoadhesive
I-HPMC isetshenziswa ekwakhiweni kwe-mucoadhesive ngenxa yekhono layo lokunamathela kuma-mucosal surfaces. Lesi sakhiwo singasetshenziswa ukuthuthukisa ukulethwa kwezidakamizwa ku-mucosa yomlomo, yamakhala, kanye ne-vaginal. I-HPMC ingase futhi yelule isikhathi sokuhlala sokwenza, ithuthukise ukumuncwa kwezidakamizwa kanye nokuba khona kwe-bioavailability.
Ukuthuthukiswa Kokuncibilika
I-HPMC ingasetshenziswa ukuthuthukisa ukunyibilika kwezidakamizwa ezingancibiliki kahle. I-HPMC yenza ama-complexes nomuthi, okwandisa ukuncibilika kwawo kanye nezinga lokuqedwa. Ubunzima buncike esisindweni samangqamuzana kanye nezinga lokushintshwa kwe-HPMC.
I-Rheology Modifier
I-HPMC ingasetshenziswa njenge-rheology modifier ekwakhiweni okuhlukahlukene. Ingakhuphula noma yehlise i-viscosity yokwakheka, kuye ngesisindo samangqamuzana nezinga lokushintshwa kwe-HPMC. Lesi sakhiwo singasetshenziswa ukulungisa izici zokugeleza kokwakheka, okwenza kube lula ukuphatha nokucubungula.
Ukwakhiwa Kokunakekelwa Komlomo
I-HPMC isetshenziswa ekwakhiweni kokunakekelwa komlomo njenge-thickener ne-binder. Ingathuthukisa ukuthungwa kanye ne-viscosity ye-toothpaste,kanye nokuthuthukisa ukuzinza kwayo. Ukwengeza, i-HPMC ingasebenza njenge-ejenti eyenza ifilimu, inikeze umgoqo ovikelayo emazinyweni nasezinsinini.
Ukwakhiwa kwe-Suppository
I-HPMC isetshenziswa ekwakhiweni kwe-suppository njengento eyisisekelo. Inganikeza ukukhululwa okulawulwayo komuthi futhi ithuthukise ukuthobela kwesiguli. Ama-suppositories e-HPMC awacasuli futhi awanabo ubuthi, okuwenza afanelekele ukusetshenziswa ezindaweni ezibucayi.
Ukwakhiwa Kokunakekelwa Kwenxeba
I-HPMC isetshenziswa ekwakhiweni kokunakekelwa kwezilonda njenge-ejenti ejiya futhi eyenza ifilimu. Kungasiza ukwakha umgoqo ovikelayo esilondeni, ukuvimbela ukutheleleka kwamagciwane kanye nokukhuthaza ukuphulukiswa. I-HPMC ingaphinde ithuthukise i-viscosity kanye nokuthungwa kwezingubo zamanxeba, ikwenze kube lula ukukusebenzisa nokukhipha.
Ukwakhiwa Kwezilwane
I-HPMC isetshenziswa ekwenziweni kodokotela wezilwane njengesihlanganisi kanye ne-disintegrant kumaphilisi namaphilisi. Ingasetshenziswa futhi njenge-thickener kuma-gel kanye nama-paste. I-HPMC iphephile ukuthi isetshenziswe ezilwaneni futhi ayinayo imiphumela emibi empilweni yazo.
I-excipient
I-HPMC ivamise ukusetshenziswa njenge-excipient ekwenziweni kwemithi. Kuyi-polymer eguquguqukayo engasetshenziswa ukuguqula izici zokwakheka. I-HPMC ayisebenzi futhi ayinabo ubuthi, okuyenza ifanelekele ukusetshenziswa kuzinhlobo eziningi zemithamo.
Sengiphetha, i-HPMC iyi-polymer esetshenziswa kakhulu embonini yezemithi ngenxa yezakhiwo zayo ezihlukile. Isetshenziswa njenge-binder, disintegrant, coating material, capsule material, viscosity enhancer, lubricant, stabilizer, suspending agent, matrix material, mucoadhesive, solubility enhancer, rheology modifier, i-ejenti eyenza ifilimu, kanye ne-excipient. I-HPMC ayinabo ubuthi, ayinabo ubuthi, futhi iphephile ukusetshenziswa kubantu nasezilwaneni. Ukuguquguquka kwayo kuyenza ibe yingxenye ebalulekile ekwenziweni kwemithi ehlukahlukene.
Isikhathi sokuthumela: Mar-05-2023