I-HPMC isebenzisa kwezemithi

IHydroxypropyl methylcellulose (HPMC) iphuma ku-cellulose esetshenziswa kakhulu embonini yezemithi ngezakhiwo zayo ezihlukile.I-semi-synthetic, i-polymer encibilikayo emanzini, kanye ne-non-ionic engasetshenziswa njenge-thickener, binder, i-ejenti yokwakha ifilimu, kanye nokothambisa.I-HPMC isizuze ukuduma kwezemithi ngenxa yekhono layo lokuthuthukisa ikhwalithi nokuzinza kwamafomu omthamo.

Kulesi sihloko, sizoxoxa ngokusetshenziswa okuhlukahlukene kwe-HPMC kwezemithi ngokuningiliziwe.

Ukwakhiwa Kwethebhulethi
I-HPMC ivamise ukusetshenziswa njengesihlanganisi ekwakhiweni kwethebhulethi.Isebenza njenge-ejenti ebophayo ngokuthuthukisa izakhiwo ezihlangene ze-tablet granules, okuholela kumaphilisi aqinile futhi angakwazi ukuwohloka.Ukwengeza, i-HPMC isetshenziswa njengesahlukanisi ekwakhiweni kwethebhulethi, ekhuthaza ukuhlakazeka kwethebhulethi nokuhlakazwa.I-HPMC ingasetshenziswa futhi njengento yokuhlanganisa amaphilisi, esiza ukuvikela umuthi endaweni ezungezile, ukuthuthukisa ukuzinza, nokulawula ukukhululwa kwezidakamizwa.

Ukwakhiwa kweCapsule
I-HPMC isetshenziswa njenge-capsule material ekwenzeni amaphilisi e-gelatin aqinile nathambile.Ingenye ye-gelatin njengoba iyimifino, ayinabuthi, futhi ayiyona i-allergenic.Amaphilisi e-HPMC nawo azinze kakhulu kunamaphilisi e-gelatin, njengoba awahlushwa ukuxhumanisa nokushintsha umbala.Amaphilisi e-HPMC angenziwa ukuthi ancibilike esiswini noma emathunjini, kuye ngephrofayili yokukhululwa edingekayo yomuthi.

Ukwakhiwa Kwamehlo
I-HPMC isetshenziswa ekwakhiweni kwe-ophthalmic njengesithuthukisi se-viscosity, enikeza isikhathi sokuxhumana esengeziwe neso kanye nokukhululwa kwezidakamizwa isikhathi eside.Ibuye isetshenziswe njenge-lubricant, enciphisa ukucasuka futhi ithuthukise ukunethezeka kwesiguli.

Ukwakhiwa Kwezihloko
I-HPMC isetshenziswa ekwakhiweni kwezihloko njenge-ejenti yokujiya, ehlinzeka nge-viscosity nokuthungwa kokhilimu, amajeli, namaloshini.Kungase futhi kuthuthukise ukuzinza kokubunjwa ngokunciphisa i-synersis nokuvimbela ukuhlukaniswa kwesigaba.

Ukwakhiwa Kwabazali
I-HPMC isetshenziswa ekwakhiweni kwabazali njengesiqinisi nokujiya.Kuyasiza ukugcina ukuzinza ngokomzimba kokubunjwa, ukuvimbela ukuhlangana kwezinhlayiyana kanye ne-sedimentation.Ibuye isetshenziswe njenge-ejenti yokumisa izidakamizwa ezingancibiliki kahle, iqinisekisa ukusatshalaliswa okufanayo komuthi ekwakhiweni.

Ukwakhiwa Kokukhishwa Okulawulwayo
I-HPMC ijwayele ukusetshenziswa ekuthuthukisweni kokwakhiwa kokukhishwa okulawulwayo.Ingasetshenziswa njengento ye-matrix, ekhulula kancane kancane umuthi ngokuhamba kwesikhathi.I-HPMC ingase futhi isetshenziselwe ukuguqula izinga lokukhululwa kwezidakamizwa ngokushintsha ukugxiliswa kwe-polymer, isisindo samangqamuzana, kanye nezinga lokushintshwa.

Ukwakhiwa kwe-Mucoadhesive
I-HPMC isetshenziswa ekwakhiweni kwe-mucoadhesive ngenxa yekhono layo lokunamathela kuma-mucosal surfaces.Lesi sakhiwo singasetshenziswa ukuthuthukisa ukulethwa kwezidakamizwa ku-mucosa yomlomo, yamakhala, kanye ne-vaginal.I-HPMC ingase futhi yelule isikhathi sokuhlala sokwenza, ithuthukise ukumuncwa kwezidakamizwa kanye nokuba khona kwe-bioavailability.

Ukuthuthukiswa Kokuncibilika
I-HPMC ingasetshenziswa ukuthuthukisa ukunyibilika kwezidakamizwa ezingancibiliki kahle.I-HPMC yenza ama-complexes nomuthi, okwandisa ukuncibilika kwawo kanye nezinga lokuqedwa.Ubunzima buncike esisindweni samangqamuzana kanye nezinga lokushintshwa kwe-HPMC.

I-Rheology Modifier
I-HPMC ingasetshenziswa njenge-rheology modifier ekwakhiweni okuhlukahlukene.Ingakhuphula noma yehlise i-viscosity yokwakheka, kuye ngesisindo samangqamuzana nezinga lokushintshwa kwe-HPMC.Lesi sakhiwo singasetshenziswa ukulungisa izici zokugeleza kokwakheka, okwenza kube lula ukuphatha nokucubungula.

Ukwakhiwa Kokunakekelwa Komlomo
I-HPMC isetshenziswa ekwakhiweni kokunakekelwa komlomo njenge-thickener ne-binder.Ingathuthukisa ukuthungwa kanye ne-viscosity ye-toothpaste,kanye nokuthuthukisa ukuzinza kwayo.Ukwengeza, i-HPMC ingasebenza njenge-ejenti eyenza ifilimu, inikeze umgoqo ovikelayo emazinyweni nasezinsinini.

Ukwakhiwa kwe-Suppository
I-HPMC isetshenziswa ekwakhiweni kwe-suppository njengento eyisisekelo.Inganikeza ukukhululwa okulawulwayo komuthi futhi ithuthukise ukuthobela kwesiguli.Ama-suppositories e-HPMC awacasuli futhi awanabo ubuthi, okuwenza afanelekele ukusetshenziswa ezindaweni ezibucayi.

Ukwakhiwa Kokunakekelwa Kwenxeba
I-HPMC isetshenziswa ekwakhiweni kokunakekelwa kwezilonda njenge-ejenti ejiya futhi eyenza ifilimu.Kungasiza ukwakha umgoqo ovikelayo esilondeni, ukuvimbela ukutheleleka kwamagciwane kanye nokukhuthaza ukuphulukiswa.I-HPMC ingaphinde ithuthukise i-viscosity kanye nokuthungwa kwezingubo zamanxeba, ikwenze kube lula ukukusebenzisa nokukhipha.

Ukwakhiwa Kwezilwane
I-HPMC isetshenziswa ekwenziweni kodokotela wezilwane njengesihlanganisi kanye ne-disintegrant kumaphilisi namaphilisi.Ingasetshenziswa futhi njenge-thickener kuma-gel kanye nama-paste.I-HPMC iphephile ukuthi isetshenziswe ezilwaneni futhi ayinayo imiphumela emibi empilweni yazo.

I-excipient
I-HPMC ivamise ukusetshenziswa njenge-excipient ekwenziweni kwemithi.Kuyi-polymer eguquguqukayo engasetshenziswa ukuguqula izici zokwakheka.I-HPMC ayisebenzi futhi ayinabo ubuthi, okuyenza ifanelekele ukusetshenziswa kuzinhlobo eziningi zemithamo.

Sengiphetha, i-HPMC iyi-polymer esetshenziswa kakhulu embonini yezemithi ngenxa yezakhiwo zayo ezihlukile.Isetshenziswa njenge-binder, disintegrant, coating material, capsule material, viscosity enhancer, lubricant, stabilizer, suspending agent, matrix material, mucoadhesive, solubility enhancer, rheology modifier, i-ejenti eyenza ifilimu, kanye ne-excipient.I-HPMC ayinabo ubuthi, ayinabo ubuthi, futhi iphephile ukuthi isetshenziswe kubantu nasezilwaneni.Ukuguquguquka kwayo kuyenza ibe yingxenye ebalulekile ekwenziweni kwemithi ehlukahlukene.