Focus on Cellulose ethers

I-HPMC isebenzisa kwezemithi

I-HPMC isebenzisa kwezemithi

IHydroxypropyl methylcellulose (HPMC) iphuma ku-cellulose esetshenziswa kakhulu embonini yezemithi ngezakhiwo zayo ezihlukile. I-semi-synthetic, i-polymer encibilikayo emanzini, kanye ne-non-ionic engasetshenziswa njenge-thickener, binder, i-ejenti yokwakha ifilimu, kanye nokothambisa. I-HPMC isizuze ukuduma kwezemithi ngenxa yekhono layo lokuthuthukisa ikhwalithi nokuzinza kwamafomu omthamo.

Impahla Incazelo
Isakhiwo samakhemikhali I-semisynthetic cellulose derivative
Isisindo samangqamuzana 10,000-1,500,000 g/mol
Izinga lokushintsha 0.9-1.7
Ukuncibilika Incibilika emanzini nasezincibilikisini eziningi eziphilayo
ukuzinza kwe-pH Izinzile phezu kwebanga le-pH elibanzi
Ukuzinza okushisayo Izinzile kufikela ku-200°C
I-Viscosity Ingasukela kokuphansi kuye phezulu kuye ngebanga
Usayizi wezinhlayiya I-100 mesh (150 microns) noma encane
Ukubukeka Impushana emhlophe ukuya kokumhlophe noma ama-granules
Iphunga Ayinaphunga
Nambitha Enganambitheki
Ubuthi Ayinabuthi futhi ayicunuli
I-Allergenicity Okungeyona i-allergenic
Odla imifino/i-vegan Abadla imifino kanye ne-vegan

 

Kulesi sihloko, sizoxoxa ngokusetshenziswa okuhlukahlukene kwe-HPMC kwezemithi ngokuningiliziwe.

 

Ukwakhiwa Kwethebhulethi
I-HPMC ivamise ukusetshenziswa njengesihlanganisi ekwakhiweni kwethebhulethi. Isebenza njenge-ejenti ebophayo ngokuthuthukisa izici ezihlangene ze-tablet granules, okuholela kumaphilisi aqinile futhi angakwazi ukuwohloka. Ukwengeza, i-HPMC isetshenziswa njengesahlukanisi ekwakhiweni kwethebhulethi, ekhuthaza ukuhlakazeka kwethebhulethi nokuhlakazwa. I-HPMC ingasetshenziswa futhi njengento yokumboza amaphilisi, esiza ukuvikela umuthi endaweni, ukuthuthukisa ukuzinza, nokulawula ukukhululwa kwezidakamizwa.

Ukwakhiwa kweCapsule
I-HPMC isetshenziswa njenge-capsule material ekwenzeni amaphilisi e-gelatin aqinile nathambile. Ingenye ye-gelatin njengoba iyimifino, ayinabuthi, futhi ayiyona i-allergenic. Amaphilisi e-HPMC nawo azinze kakhulu kunamaphilisi e-gelatin, njengoba awahlushwa ukuxhumanisa nokushintsha umbala. Amaphilisi e-HPMC angenziwa ukuthi ancibilike esiswini noma emathunjini, kuye ngephrofayili yokukhululwa edingekayo yomuthi.

Ukwakhiwa Kwamehlo
I-HPMC isetshenziswa ekwakhiweni kwe-ophthalmic njengesithuthukisi se-viscosity, enikeza isikhathi sokuxhumana esengeziwe neso kanye nokukhululwa kwezidakamizwa isikhathi eside. Ibuye isetshenziswe njenge-lubricant, enciphisa ukucasuka futhi ithuthukise ukunethezeka kwesiguli.

Ukwakhiwa Kwezihloko
I-HPMC isetshenziswa ekwakhiweni kwezihloko njenge-ejenti yokujiya, ehlinzeka nge-viscosity nokuthungwa kokhilimu, amajeli, namaloshini. Kungase futhi kuthuthukise ukuzinza kokubunjwa ngokunciphisa i-synersis nokuvimbela ukuhlukaniswa kwesigaba.

Ukwakhiwa Kwabazali
I-HPMC isetshenziswa ekwakhiweni kwabazali njengesiqinisi nokujiya. Kuyasiza ukugcina ukuzinza ngokomzimba kokubunjwa, ukuvimbela ukuhlangana kwezinhlayiyana kanye ne-sedimentation. Ibuye isetshenziswe njenge-ejenti yokumisa izidakamizwa ezingancibiliki kahle, iqinisekisa ukusatshalaliswa okufanayo komuthi ekwakhiweni.

Ukwakhiwa Kokukhishwa Okulawulwayo
I-HPMC ijwayele ukusetshenziswa ekuthuthukisweni kokwakhiwa kokukhishwa okulawulwayo. Ingasetshenziswa njengento ye-matrix, ekhulula kancane kancane umuthi ngokuhamba kwesikhathi. I-HPMC ingase futhi isetshenziselwe ukuguqula izinga lokukhululwa kwezidakamizwa ngokushintsha ukugxiliswa kwe-polymer, isisindo samangqamuzana, kanye nezinga lokushintshwa.

Ukwakhiwa kwe-Mucoadhesive
I-HPMC isetshenziswa ekwakhiweni kwe-mucoadhesive ngenxa yekhono layo lokunamathela kuma-mucosal surfaces. Lesi sakhiwo singasetshenziswa ukuthuthukisa ukulethwa kwezidakamizwa ku-mucosa yomlomo, yamakhala, kanye ne-vaginal. I-HPMC ingase futhi yelule isikhathi sokuhlala sokwenza, ithuthukise ukumuncwa kwezidakamizwa kanye nokuba khona kwe-bioavailability.

Ukuthuthukiswa Kokuncibilika
I-HPMC ingasetshenziswa ukuthuthukisa ukunyibilika kwezidakamizwa ezingancibiliki kahle. I-HPMC yenza ama-complexes nomuthi, okwandisa ukuncibilika kwawo kanye nezinga lokuqedwa. Ubunzima buncike esisindweni samangqamuzana kanye nezinga lokushintshwa kwe-HPMC.

I-Rheology Modifier
I-HPMC ingasetshenziswa njenge-rheology modifier ekwakhiweni okuhlukahlukene. Ingakhuphula noma yehlise i-viscosity yokwakheka, kuye ngesisindo samangqamuzana nezinga lokushintshwa kwe-HPMC. Lesi sakhiwo singasetshenziswa ukulungisa izici zokugeleza kokwakheka, okwenza kube lula ukuphatha nokucubungula.

Ukwakhiwa Kokunakekelwa Komlomo
I-HPMC isetshenziswa ekwakhiweni kokunakekelwa komlomo njenge-thickener ne-binder. Ingathuthukisa ukuthungwa kanye ne-viscosity ye-toothpaste,kanye nokuthuthukisa ukuzinza kwayo. Ukwengeza, i-HPMC ingasebenza njenge-ejenti eyenza ifilimu, inikeze umgoqo ovikelayo emazinyweni nasezinsinini.

Ukwakhiwa kwe-Suppository
I-HPMC isetshenziswa ekwakhiweni kwe-suppository njengento eyisisekelo. Inganikeza ukukhululwa okulawulwayo komuthi futhi ithuthukise ukuthobela kwesiguli. Ama-suppositories e-HPMC awacasuli futhi awanabo ubuthi, okuwenza afanelekele ukusetshenziswa ezindaweni ezibucayi.

Ukwakhiwa Kokunakekelwa Kwenxeba
I-HPMC isetshenziswa ekwakhiweni kokunakekelwa kwezilonda njenge-ejenti ejiya futhi eyenza ifilimu. Kungasiza ukwakha umgoqo ovikelayo esilondeni, ukuvimbela ukutheleleka kwamagciwane kanye nokukhuthaza ukuphulukiswa. I-HPMC ingaphinde ithuthukise i-viscosity kanye nokuthungwa kwezingubo zamanxeba, ikwenze kube lula ukukusebenzisa nokukhipha.

Ukwakhiwa Kwezilwane
I-HPMC isetshenziswa ekwenziweni kodokotela wezilwane njengesihlanganisi kanye ne-disintegrant kumaphilisi namaphilisi. Ingasetshenziswa futhi njenge-thickener kuma-gel kanye nama-paste. I-HPMC iphephile ukuthi isetshenziswe ezilwaneni futhi ayinayo imiphumela emibi empilweni yazo.

I-excipient
I-HPMC ivamise ukusetshenziswa njenge-excipient ekwenziweni kwemithi. Kuyi-polymer eguquguqukayo engasetshenziswa ukuguqula izici zokwakheka. I-HPMC ayisebenzi futhi ayinabo ubuthi, okuyenza ifanelekele ukusetshenziswa kuzinhlobo eziningi zemithamo.

Sengiphetha, i-HPMC iyi-polymer esetshenziswa kakhulu embonini yezemithi ngenxa yezakhiwo zayo ezihlukile. Isetshenziswa njenge-binder, disintegrant, coating material, capsule material, viscosity enhancer, lubricant, stabilizer, suspending agent, matrix material, mucoadhesive, solubility enhancer, rheology modifier, i-ejenti eyenza ifilimu, kanye ne-excipient. I-HPMC ayinabo ubuthi, ayinabo ubuthi, futhi iphephile ukusetshenziswa kubantu nasezilwaneni. Ukuguquguquka kwayo kuyenza ibe yingxenye ebalulekile ekwenziweni kwemithi ehlukahlukene.

 

 


Isikhathi sokuthumela: Mar-05-2023
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