1. Ubume beMichiza ye-HPMC:
I-HPMC yi-semi-synthetic, inert, i-viscoelastic polymer ephuma kwi-cellulose.Iqulethwe ngamayunithi aphinda-phindayo eemolekyuli zeglucose ezidityaniswe kunye, kunye namanqanaba ahlukeneyo okutshintsha.Ukutshintshwa kubandakanya i-hydroxypropyl (-CH2CHOHCH3) kunye namaqela e-methoxy (-OCH3) aqhotyoshelwe kwiiyunithi ze-anhydroglucose ze-cellulose.Olu tshintsho lunika iipropati ezizodwa kwi-HPMC, kubandakanywa nokunyibilika kwayo emanzini.
2. Ukudityaniswa kweHydrojeni:
Esinye sezizathu eziphambili zokunyibilika kwe-HPMC emanzini kukukwazi ukwenza iibhondi ze-hydrogen.Ukudibanisa i-Hydrogen kwenzeka phakathi kwamaqela e-hydroxyl (OH) e-HPMC kunye ne-molecule zamanzi.Amaqela e-hydroxyl kwiimolekyuli ze-HPMC anokunxibelelana neemolekyuli zamanzi ngokusebenzisa i-hydrogen bonding, iququzelele inkqubo yokuchithwa.La mandla e-intermolecular abalulekile ekwaphuleni amandla anomtsalane phakathi kweemolekyuli ze-HPMC kunye nokwenza ukuba zisasazeke emanzini.
3. Isidanga soTshintsho:
Iqondo lokutshintshela (DS) libhekisa kwiavareji yenani le-hydroxypropyl kunye namaqela e-methoxy ngeyunithi ye-anhydroglucose kwi-molecule ye-HPMC.Amaxabiso aphezulu e-DS aphucula ngokubanzi ukunyibilika kwamanzi kwe-HPMC.Oku kungenxa yokuba inani elongezelelweyo le-hydrophilic substituents liphucula intsebenziswano yepolymer kunye neemolekyuli zamanzi, ukukhuthaza ukuchithwa.
4. Ubunzima beMolekyuli:
Ubunzima bemolekyuli ye-HPMC ikwaphembelela ukunyibilika kwayo.Ngokubanzi, amabanga asezantsi obunzima bemolekyuli HPMC abonisa ukunyibilika okungcono emanzini.Oku kungenxa yokuba amakhonkco amancinci epolymer aneendawo ezifikeleleka ngakumbi zokunxibelelana neemolekyuli zamanzi, ezikhokelela ekunyibilikeni ngokukhawuleza.
5. Isimilo sokudumba:
I-HPMC inamandla okudumba kakhulu xa ibhengezwe emanzini.Oku kudumba kwenzeka ngenxa yobume bepolymer's hydrophilic kunye nokukwazi kwayo ukufunxa iimolekyuli zamanzi.Njengoko amanzi engena kwi-matrix ye-polymer, iphazamisa amandla e-intermolecular phakathi kwamatyathanga e-HPMC, okukhokelela ekuhlukaneni kwawo kunye nokusabalalisa kwi-solvent.
6. Indlela yokusasaza:
Ukunyibilika kwe-HPMC emanzini kukwaphenjelelwa yindlela yokusasazwa kwayo.Xa i-HPMC yongezwa emanzini, ingena kwinkqubo yokumanzisa, apho iimolekyuli zamanzi zijikeleze amasuntswana epolymer.Emva koko, iinqununu ze-polymer zichithakala kuyo yonke i-solvent, incediswa ngukuphazamiseka okanye ukuxutywa komatshini.Inkqubo yokusabalalisa iququzelelwa yi-hydrogen bonding phakathi kwe-HPMC kunye neemolekyuli zamanzi.
7. Amandla e-Ionic kunye ne-pH:
Amandla e-ionic kunye ne-pH yesisombululo inokuchaphazela ukunyibilika kwe-HPMC.I-HPMC inyibilika ngakumbi emanzini ngamandla e-ionic aphantsi kunye ne-pH ekufutshane-phakathi.Izisombululo zamandla e-ionic aphezulu okanye iimeko ezigqithisileyo ze-pH zinokuphazamisana ne-hydrogen bonding phakathi kwe-HPMC kunye ne-molecule zamanzi, ngaloo ndlela ukunciphisa ukunyibilika kwayo.
8. Ubushushu:
Ubushushu bunokuchaphazela ukunyibilika kwe-HPMC emanzini.Ngokubanzi, amaqondo okushisa aphezulu aphakamisa izinga lokuchithwa kwe-HPMC ngenxa yokwanda kwamandla e-kinetic, okukhuthaza ukunyakaza kwee-molecular kunye nokusebenzisana phakathi kwepolymer kunye ne-molecule yamanzi.
9. Ukugxila:
Ukuxinwa kwe-HPMC kwisisombululo kunokuchaphazela ukunyibilika kwayo.Kwiindawo ezisezantsi, i-HPMC inyibilika ngokulula emanzini.Nangona kunjalo, njengoko uxinaniso lukhula, amatyathanga epolymer anokuqalisa ukudityaniswa okanye ukubambisa, okukhokelela ekunciphiseni ukunyibilika.
10. Indima kuCwangciso lwezaMachiza:
I-HPMC isetyenziswa ngokubanzi kuqulunqo lwamachiza njengepolymer ye-hydrophilic ukuphucula ukunyibilika kwechiza, ukufumaneka kwe-bioavailability, kunye nokukhululwa okulawulwayo.Ukunyibilika kwayo okugqwesileyo kwamanzi kuvumela ukulungiswa kweefom zedosi ezizinzileyo nezihlakazeka ngokulula ezifana neetafile, iicapsules, kunye nokuxhonywa.
ukunyibilika kwe-HPMC emanzini kubalelwa kubume bayo beekhemikhali ezizodwa, ezibandakanya i-hydrophilic hydroxypropyl kunye namaqela e-methoxy, iququzelela ukuhlangana kwe-hydrogen kunye neemolekyuli zamanzi.Ezinye izinto ezinje ngeqondo lokutshintsha, ubunzima bemolekyuli, isimilo sokudumba, indlela yokusasazeka, amandla e-ionic, i-pH, ubushushu, kunye noxinzelelo nazo zinefuthe kwiipropati zayo zokunyibilika.Ukuqonda ezi zinto kubalulekile ekusebenziseni i-HPMC ngempumelelo kwizicelo ezahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa, kunye namanye amashishini.
Ixesha lokuposa: Mar-21-2024