1. Tsarin Sinadarai na HPMC:
HPMC Semi-synthetic ne, inert, polymer viscoelastic da aka samu daga cellulose.Ya ƙunshi maimaita raka'a na kwayoyin glucose da aka haɗe tare, tare da nau'o'in canji daban-daban.Canjin ya ƙunshi hydroxypropyl (-CH2CHOHCH3) da ƙungiyoyin methoxy (-OCH3) waɗanda ke haɗe zuwa raka'o'in anhydroglucose na cellulose.Wannan canji yana ba da kadarori na musamman ga HPMC, gami da narkewar ruwa.
2. Haɗin Ruwa:
Ɗaya daga cikin dalilan farko na narkewar ruwa na HPMC shine ikonsa na samar da haɗin gwiwar hydrogen.Haɗin hydrogen yana faruwa tsakanin ƙungiyoyin hydroxyl (OH) na HPMC da kwayoyin ruwa.Ƙungiyoyin hydroxyl a cikin kwayoyin HPMC suna iya yin hulɗa tare da kwayoyin ruwa ta hanyar haɗin gwiwar hydrogen, suna sauƙaƙe tsarin rushewa.Wadannan rundunonin kwayoyin halitta suna da mahimmanci don wargaza runduna masu ban sha'awa tsakanin kwayoyin HPMC da ba da damar tarwatsa su cikin ruwa.
3. Digiri na Canji:
Matsayin maye gurbin (DS) yana nufin matsakaicin adadin hydroxypropyl da ƙungiyoyin methoxy a kowace naúrar anhydroglucose a cikin kwayoyin HPMC.Maɗaukakin ƙimar DS gabaɗaya yana haɓaka solubility na ruwa na HPMC.Wannan saboda karuwar adadin abubuwan maye gurbin ruwa yana inganta hulɗar polymer tare da kwayoyin ruwa, yana inganta rushewa.
4. Nauyin Kwayoyin Halitta:
Nauyin kwayoyin halitta na HPMC kuma yana tasiri da solubility.Gabaɗaya, ƙananan makin HPMC suna nuna mafi kyawu a cikin ruwa.Wannan saboda ƙananan sarƙoƙi na polymer suna da ƙarin wuraren samun damar yin hulɗa tare da kwayoyin ruwa, wanda ke haifar da rushewa cikin sauri.
5. Halayen Kumburi:
HPMC yana da ikon kumbura sosai lokacin da aka fallasa ruwa.Wannan kumburi yana faruwa ne saboda yanayin hydrophilic na polymer da kuma ikonsa na ɗaukar kwayoyin ruwa.Yayin da ruwa ke shiga matrix na polymer, yana rushe rundunonin intermolecular tsakanin sarƙoƙi na HPMC, wanda ke haifar da rabuwa da tarwatsewa a cikin sauran ƙarfi.
6. Tsarin Watsawa:
Solubility na HPMC a cikin ruwa kuma yana tasiri ta hanyar watsawa.Lokacin da aka ƙara HPMC a cikin ruwa, ana yin aikin jika, inda kwayoyin ruwa ke kewaye da ƙwayoyin polymer.Daga baya, ƙwayoyin polymer suna tarwatsa ko'ina cikin sauran ƙarfi, suna taimakon tashin hankali ko haɗawar inji.Ana sauƙaƙe tsarin watsawa ta hanyar haɗin gwiwar hydrogen tsakanin HPMC da kwayoyin ruwa.
7. Ƙarfin Ionic da pH:
Ƙarfin ionic da pH na maganin zai iya rinjayar solubility na HPMC.HPMC ya fi narkewa cikin ruwa tare da ƙarancin ƙarfin ionic da pH na kusa-tsaki.Maganin ƙarfin ƙarfin ionic ko matsananciyar yanayin pH na iya tsoma baki tare da haɗin gwiwar hydrogen tsakanin HPMC da kwayoyin ruwa, don haka rage narkewar sa.
8. Zazzabi:
Zazzabi kuma na iya yin tasiri akan solubility na HPMC a cikin ruwa.Gabaɗaya, yanayin zafi mafi girma yana haɓaka ƙimar rushewar HPMC saboda haɓakar kuzarin motsa jiki, wanda ke haɓaka motsin ƙwayoyin cuta da hulɗa tsakanin polymer da ƙwayoyin ruwa.
9. Hankali:
Ƙaddamar da HPMC a cikin maganin zai iya tasiri ga solubility.A ƙananan ƙididdiga, HPMC ya fi saurin narkewa cikin ruwa.Duk da haka, yayin da maida hankali ya karu, sarƙoƙin polymer na iya fara haɗuwa ko haɗuwa, wanda zai haifar da raguwar solubility.
10. Gudunmawa a cikin Tsarin Magunguna:
Ana amfani da HPMC sosai a cikin ƙirar magunguna azaman polymer na hydrophilic don haɓaka solubility na miyagun ƙwayoyi, haɓakar halittu, da sakin sarrafawa.Kyakkyawan solubility na ruwa yana ba da izini don shirye-shiryen barga da sauƙin rarraba nau'ikan nau'ikan sashi kamar allunan, capsules, da dakatarwa.
Solubility na HPMC a cikin ruwa ana danganta shi da tsarin sinadarai na musamman, wanda ya haɗa da hydrophilic hydroxypropyl da ƙungiyoyin methoxy, sauƙaƙe haɗin gwiwar hydrogen tare da kwayoyin ruwa.Wasu dalilai kamar matakin maye gurbin, nauyin kwayoyin halitta, halayen kumburi, tsarin watsawa, ƙarfin ionic, pH, zafin jiki, da maida hankali kuma suna yin tasiri ga abubuwan solubility.Fahimtar waɗannan abubuwan yana da mahimmanci don amfani da HPMC yadda ya kamata a aikace-aikace daban-daban, gami da magunguna, abinci, kayan kwalliya, da sauran masana'antu.
Lokacin aikawa: Maris 21-2024