Ngaba i-HPMC yihydrogel?

IHydroxypropyl methylcellulose (HPMC) yipolymer esetyenziswa ngeendlela ezahlukeneyo kumashishini ahlukeneyo ngenxa yeempawu zayo ezizodwa.Nangona ingasetyenziselwa ukwenza i-hydrogels phantsi kweemeko ezithile, ayisiyiyo i-hydrogel ngokwayo.

1. Intshayelelo kwi-HPMC:

IHydroxypropyl methylcellulose (HPMC) yi-semi-synthetic polymer ephuma kwi-cellulose, ipholima yendalo efumaneka kwiindonga zeeseli zezityalo.Yenziwa ngokuphatha i-cellulose nge-alkali kwaye emva koko iphendule ngepropylene oxide kunye ne-methyl chloride.Ipolymer enesiphumo ibonisa uluhlu lweepropathi ezenza ukuba zixabiseke kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa kunye nokwakha.

2. Iipropati ze-HPMC:

I-HPMC ineempawu ezininzi eziluncedo:

a.Ukunyibilika kwamanzi:

I-HPMC iyanyibilika emanzini, yenze izisombululo ze-viscous.Le propati iluncedo ngokukhethekileyo kumayeza, apho ingasetyenziselwa ukudala ukumiswa, i-emulsions, kunye nokuqulunqwa kweziyobisi ezilawulwayo.

b.Isakhono sokwenza ifilim:

I-HPMC inokwenza iifilimu eziguquguqukayo nezingafihliyo xa iphoswe kwizisombululo zayo ezinamanzi.Ezi filimu zifumana usetyenziso kwiingubo zeetafile, iipilisi, kunye neefilimu zomlomo.

c.Isilungisi seRheology:

I-HPMC isebenza njenge-thickener kunye ne-rheology modifier kwizisombululo ezinamanzi.I-viscosity yayo inokulungelelaniswa ngokulungelelanisa izinto ezifana nobunzima be-molecular kunye neqondo lokuthatha indawo.

d.Biocompatibility:

I-HPMC i-biocompatible kwaye ayinayo ityhefu, iyenza ilungele ukusetyenziswa kumayeza, izithambiso, kunye neemveliso zokutya.

3. Usetyenziso lwe-HPMC:

I-HPMC ifumana izicelo ezixhaphakileyo kuwo wonke amashishini ahlukeneyo:

a.Amachiza:

Kuqulunqo lwamayeza, i-HPMC isetyenziswa njenge-binder, i-disintegrant, i-agent-coating agent, kunye ne-matrix yokukhululwa okuqhubekayo.Iphucula ingqibelelo yethebhulethi, ilawula i-kinetics yokukhululwa kweziyobisi, kwaye iphucula ukuthotyelwa kwesigulane.

b.Ishishini lokutya:

Kushishino lokutya, i-HPMC iqeshwe njenge-thickener, emulsifier, stabilizer, kunye ne-gelling agent.Inegalelo kuthungelwano, i-viscosity, kunye nokuzinza kweemveliso zokutya ezifana neesosi, izinxibo, kunye nezimuncumuncu.

c.Izithambiso:

I-HPMC isetyenziswa kwizinto zokuthambisa kunye neemveliso zokhathalelo lobuqu njenge-thickener, i-arhente exhomayo, ifilimu yangaphambili, kunye ne-emulsifier.Inika iipropathi ezinqwenelekayo ze-rheological kwiikhrimu, izinto zokuthambisa, kunye neejeli ngelixa zikhulisa uzinzo kunye neempawu zoluvo.

d.Ulwakhiwo:

Kushishino lokwakha, i-HPMC isetyenziswa kwimathiriyeli yesamente njengearhente yokugcina amanzi, isixhasi sokusebenza, kunye nearhente yokujiya.Iphucula iimpawu zodaka kunye ne-plaster, ezifana nokunamathela, ukudibanisa, kunye nokuxhathisa i-sag.

4. Ukwenziwa kweHydrogel kunye ne-HPMC:

Nangona i-HPMC ngokwayo ayiyona i-hydrogel, inokuthatha inxaxheba ekubunjweni kwe-hydrogel phantsi kweemeko ezifanelekileyo.I-hydrogel yinethiwekhi yamakhonkco e-polymer ekwazi ukufunxa kunye nokugcina amanzi amaninzi.Ukwenziwa kwee-hydrogel ze-HPMC ngokuqhelekileyo kubandakanya ukunqumla amatsheyina epolymer ukwenza inethiwekhi ene-dimensional-dimensional ekwaziyo ukufunxa amanzi.

a.Iiarhente ezidibanisayo:

Ii-agent ezidibanisayo ezifana ne-glutaraldehyde, i-genipin, okanye iindlela zomzimba ezifana ne-freeze-nying cycle zingaqeshwa ukuwela amatyathanga e-HPMC.Oku kunqunyulwa kweziphumo ekwenziweni kwenethiwekhi ye-hydrogel ngaphakathi kwe-matrix ye-HPMC.

b.Ukudumba:

Iimpawu ze-hydrogel ze-HPMC zinokulungelelaniswa ngokulungelelanisa izinto ezifana neqondo lokutshintshela, ubunzima bemolekyuli, kunye noxinaniso olunqamlezayo.Amanqanaba aphezulu okutshintsha kunye nobunzima beemolekyuli ngokubanzi bukhokelela ekwandeni kwe-hydrogel amandla okudumba.

c.Ukusetyenziswa kwe-HPMC Hydrogels:

I-HPMC hydrogels ifumana izicelo ekuhanjisweni kweziyobisi, ukuphiliswa kwenxeba, ubunjineli beethishu, kunye neelensi zoqhagamshelwano.I-biocompatibility yabo, iipropathi ezinokutyhutyhwa, kunye nokukwazi ukugcina amanzi kubenza bafaneleke kwizicelo ezahlukeneyo ze-biomedical.

I-HPMC yipolymer eguquguqukayo enezicelo ezahlukeneyo kuwo wonke amayeza, ukutya, izinto zokuthambisa, kunye namashishini okwakha.Ngelixa ingeyiyo i-hydrogel ngokwendalo, inokuthatha inxaxheba ekwenziweni kwe-hydrogel ngokudibanisa amakhonkco ayo epolymer.Iziphumo ze-HPMC ze-hydrogels zibonisa iipropati ezifana nokufunxa kwamanzi kunye nokugcinwa, okwenza zibe luncedo kwizicelo ze-biomedical.Njengoko uphando luqhubeka nokuphonononga ukusetyenziswa kwenoveli kunye noyilo lwe-HPMC, ukubaluleka kwayo kumashishini ahlukeneyo kulindeleke ukuba kwandiswe ngakumbi.