I-HPMC Yokugquma ifilimu yeCwecwe

I-HPMC, okanye i-Hydroxypropyl Methylcellulose, yinto esetyenziswa ngokuqhelekileyo kwishishini lamayeza, ngokukodwa ukuveliswa kweengubo zefilimu yethebhulethi.Iingubo zefilimu zifakwe kwiipilisi ukukhusela isithako esisebenzayo, imaski incasa engathandekiyo okanye ivumba, kunye nokuphucula ukubonakala kwethebhulethi.I-HPMC sisixhobo esifanelekileyo sokugquma ifilimu ngenxa yokuhambelana kwayo nezinto eziphilayo, ubuthi obuphantsi, kunye neempawu ezibalaseleyo zokwenza ifilim.

I-HPMC yipolymer eyi-hydrophilic enyibilikayo emanzini, iyenza ilungele ukusetyenziswa kwiingubo zefilimu ezinamanzi.Kwakhona izinzile kumanqanaba ahlukeneyo e-pH, okwenza ukuba ifaneleke ukusetyenziswa kuluhlu olubanzi lokuqulunqwa kwamachiza.Ifilimu yokwenza ifilimu ye-HPMC ibangelwa ukukwazi ukudala inethiwekhi ye-hydrogen bonds kunye neamolekyu zamanzi, eziphumela kwifilimu eqinile kwaye eguquguqukayo.

Ukusetyenziswa kwe-HPMC kwiingubo zefilimu yethebhulethi ibonelela ngeenzuzo ezininzi, kubandakanya:

Inkangeleko ephuculweyo: I-HPMC ingasetyenziselwa ukwenza iifilimu ezigudileyo, ezicwebezelayo eziphucula inkangeleko yethebhulethi.Ikwafumaneka kuluhlu lwemibala, evumela ukwenziwa kwembonakalo yethebhulethi.

Ukukhutshwa okulawulwayo: I-HPMC ingasetyenziselwa ukudala iifomyula ezilawulwayo, ezinokubonelela ngokukhutshwa okuzinzileyo kwesithako esisebenzayo kwixesha elithile.Oku kunokuba luncedo ngakumbi kumachiza afuna ishedyuli ethile yokudosa.

Ukufihla incasa: I-HPMC ingasetyenziselwa ukugquma incasa engathandekiyo okanye ivumba elinxulunyaniswa namanye amachiza, ezenza kube lula ukuwaginya.

Ukhuseleko: I-HPMC ingasetyenziselwa ukukhusela isithako esisebenzayo kwithebhulethi ekuthotyweni ngenxa yokuvezwa kukukhanya, ukufuma, okanye ezinye izinto zokusingqongileyo.

I-Biocompatibility: I-HPMC i-biocompatible, ithetha ukuba inyamezeleke kakuhle ngumzimba womntu kwaye ayivelisi nayiphi na imiphumo emibi.

Xa usebenzisa i-HPMC kwi-tablet film coatings, kukho izinto ezininzi ekufuneka zithathelwe ingqalelo, kubandakanya:

Ukunyibilika: I-HPMC yimathiriyeli ye-hydrophilic kwaye iyanyibilika emanzini.Nangona kunjalo, ukunyibilika kwe-HPMC kunokuchatshazelwa zizinto ezinjenge-pH, ubushushu, kunye namandla e-ionic.Kubalulekile ukukhetha uhlobo oluchanekileyo lwe-HPMC kwisicelo esijoliswe ekuqinisekiseni ukuba inyibilika ngokufanelekileyo.

I-Viscosity: I-HPMC ifumaneka kuluhlu lwamabakala e-viscosity, olunokuthi lube nefuthe lokukhululeka kokulungiswa kunye nobukhulu befilimu ebangelwayo.Ibakala elifanelekileyo le-viscosity kufuneka likhethwe ngokusekelwe kwiimfuno ezithile zokuqulunqa.

Ugxininiso: Ukugxininiswa kwe-HPMC kwisisombululo sokugquma kunokuchaphazela ubukhulu kunye neempawu zomatshini zefilimu.Ugxininiso olufanelekileyo kufuneka lugqitywe ngokusekelwe kwiimfuno ezithile zokuqulunqwa.

Iiparamitha zokucubungula: Iiparamitha zokusetyenzwa zokusebenzisa ifilimu yokugquma, njengeqondo lokushisa, ukufuma, kunye nokuhamba komoya, kunokuchaphazela umgangatho wefilimu enesiphumo.Kubalulekile ukulawula ngokucophelela ezi parameters ukuqinisekisa umgangatho wefilimu ohambelanayo.

Inkqubo yokufaka i-HPMC yokugquma ifilimu kwithebhulethi ibandakanya amanyathelo amaninzi, kuquka:

Ukulungiswa kwesisombululo sokugquma: I-HPMC idla ngokuchithwa emanzini okanye kumxube wotywala wamanzi ukwenza isisombululo sokugquma.Ugxininiso olufanelekileyo kunye nebakala le-viscosity le-HPMC kufuneka likhethwe ngokusekelwe kwiimfuno ezithile zokuqulunqa.

Ukutshiza isisombululo sokugquma: Ithebhulethi ifakwe kwi-pan yokugubungela kwaye ijikelezwe ngelixa isisombululo sokugubungela sitshizwa phezu kwethebhulethi usebenzisa isibhamu sokutshiza.Isisombululo sokugquma sinokutshizwa kwiingqimba ezininzi ukufezekisa ubukhulu obufunwayo.

Ukomisa ifilimu: Iipilisi ezigqunyiweyo zomiswa kwi-oven yomoya oshushu ukususa i-solvent kunye nokuqinisa ifilimu.Iimeko zokumisa kufuneka zilawulwe ngononophelo ukuze kuqinisekiswe ukuba ifilimu ayidli kakhulu okanye yomiswe.

Ukuhlolwa kunye nokupakishwa: Iipilisi ezigqunyiweyo zihlolwe umgangatho kunye nokuhambelana