HPMC YeTablet film coating

HPMC, kana Hydroxypropyl Methylcellulose, chinhu chinowanzo shandiswa muindasitiri yemishonga, kunyanya kugadzirwa kwemahwendefa emufirimu.Mafirimu ekuputira anoshandiswa pamapiritsi kuchengetedza chinhu chinoshanda, mask inonaka isingafadzi kana kunhuhwirira, uye kuvandudza kutaridzika kwehwendefa.HPMC chinhu chakanakira mabhaisikopo ekuputira nekuda kweiyo biocompatibility, yakaderera muchetura, uye yakanakisa firimu-kugadzira zvimiro.

HPMC inonzi hydrophilic polymer inonyungudika mumvura, ichiita kuti ive yakakodzera kushandiswa mune aqueous film coatings.Iyo zvakare yakagadzikana pamazinga akasiyana epH, izvo zvinoita kuti ive yakakodzera kushandiswa mune dzakasiyana siyana dzekugadzira zvinodhaka.Iyo firimu-kugadzira kugona kweHPMC kunokonzerwa nekukwanisa kwayo kugadzira network yehydrogen zvisungo nemamorekuru emvura, izvo zvinoguma mune yakasimba uye inoshanduka firimu.

Iko kushandiswa kweHPMC mune piritsi firimu rejasi kunopa akati wandei mabhenefiti, anosanganisira:

Chitarisiko chakavandudzwa: HPMC inogona kushandiswa kugadzira akatsetseka, anopenya mafirimu anowedzera kutaridzika kwehwendefa.Inowanikwawo mumhando dzakasiyana dzemavara, zvichibvumira kugadziridzwa kwechimiro chehwendefa.

Inodzorwa kuburitswa: HPMC inogona kushandiswa kugadzira inodzorwa-kuburitsa maumbirwo, ayo anogona kupa kuburitswa kwakasimba kwechinhu chinoshanda pane imwe nguva yakatarwa.Izvi zvinogona kunyanya kubatsira kune zvinodhaka zvinoda yakatarwa dosing chirongwa.

Kuravira masking: HPMC inogona kushandiswa kuvhara zvinonaka zvisingafadzi kana kunhuhwirira kwakabatana nemimwe mishonga, zvichiita kuti zvive nyore kumedza.

Dziviriro: HPMC inogona kushandiswa kuchengetedza iyo inoshanda mupiritsi kubva mukuora nekuda kwekuratidzwa kune mwenje, hunyoro, kana zvimwe zvakatipoteredza.

Biocompatibility: HPMC ndeye biocompatible, zvichireva kuti inobvumirwa zvakanaka nemuviri wemunhu uye haiburitse chero mhedzisiro yakaipa.

Paunenge uchishandisa HPMC yepiritsi firimu rejasi, pane akati wandei zvinhu zvinofanirwa kuverengerwa, zvinosanganisira:

Solubility: HPMC ndeye hydrophilic zvinhu uye inonyungudika mumvura.Nekudaro, iyo solubility yeHPMC inogona kukanganiswa nezvinhu zvakaita sepH, tembiricha, uye ionic simba.Izvo zvakakosha kuti usarudze iyo chaiyo mhando yeHPMC yeyakagadzirirwa application kuti ive nechokwadi chekuti inonyungudika nemazvo.

Viscosity: HPMC inowanikwa mumhando dzakasiyana-siyana dzeviscosity mamakisi, izvo zvinogona kukanganisa kureruka kwekugadzirisa uye ukobvu hweiyo firimu rinobuda.Iyo yakakodzera viscosity giredhi inofanirwa kusarudzwa zvichibva pane chaiyo yekuumba zvinodiwa.

Concentration: Iyo yekumisikidzwa kweHPMC mune yekubikira mhinduro inogona kukanganisa ukobvu uye mechaniki zvimiro zvefirimu.Iko kusungirirwa kwakakodzera kunofanira kugadziriswa zvichienderana nezvinodiwa zvekugadzirisa.

Kugadzirisa maparamendi: Iwo maparamendi ekugadzirisa ekuisa iyo firimu yekuputira, senge tembiricha, humidity, uye kuyerera kwemhepo, inogona kukanganisa kunaka kwerinobuda firimu.Izvo zvakakosha kuti unyatso kudzora ma parameter aya kuti uve nechokwadi chekuenderana kwemafirimu emhando.

Maitiro ekushandisa iyo HPMC firimu yekuputira pahwendefa inosanganisira akati wandei matanho, anosanganisira:

Kugadzirira kwekugadzirisa kwekugadzirisa: HPMC inowanzonyungudutswa mumvura kana musanganiswa wemvura-doro kugadzira mhinduro yekuputira.Iyo yakakodzera yekumisikidza uye viscosity giredhi yeHPMC inofanirwa kusarudzwa zvichibva pane chaiyo yekuumba zvinodiwa.

Kupfapfaidza mushonga wekuputira: Chipiritsi chinoiswa mupani yekuputira uye chichitenderedzwa apo mushonga wekupotera uchipfapfaidzwa pamusoro pehwendefa uchishandisa pfuti yekupfapfaidza.Iyo yekuputira mhinduro inogona kupfapfaidzwa muzvikamu zvakawanda kuti uwane ukobvu hunodiwa.

Kuomesa firimu: Mahwendefa akavharidzirwa anobva aomeswa muvheni inopisa yemhepo kuti abvise solvent uye kusimbisa firimu.Mamiriro ekuomeswa anofanira kunyatsodzorwa kuti ave nechokwadi chokuti firimu haina kunyanya kuomeswa kana kuoma.

Kuongorora uye kurongedza: Mahwendefa akavharidzirwa anoongororwa mhando uye kuenderana