Ukudilutywa kwe-Hydroxypropyl Methylcellulose (HPMC) kubandakanya ukuyisasaza kwisinyibilikisi ngelixa igcina ugxininiso olufunekayo.I-HPMC yipolymer ephuma kwiselulosi, edla ngokusetyenziswa kumayeza, kwizinto zokuthambisa, nakwizinto zokwakha zokujiya, ukubopha, kunye neempawu zokwenza ifilim.Ukunciphisa kunokuba yimfuneko kwizicelo ezahlukeneyo, ezifana nokulungelelanisa i-viscosity okanye ukufezekisa ukuhambelana okufunekayo.
1. Ukuqonda i-HPMC:
IiPropati zeMichiza: I-HPMC yipolima enyibilikayo emanzini enokunyibilika okwahluka-hlukeneyo ngokuxhomekeke kwiqondo lokuthatha indawo (DS) kunye nobunzima bemolekyuli (MW).
I-Viscosity: I-viscosity yayo kwisisombululo ixhomekeke ekugxininiseni, ubushushu, i-pH, kunye nobukho beetyuwa okanye ezinye izongezo.
2. Ukukhethwa kwesinyibilikisi:
Amanzi: I-HPMC iqhele ukunyibilika emanzini abandayo, yenze izisombululo ezicacileyo okanye ezinodaka.
Ezinye izinyibilikisi: I-HPMC inokunyibilika kwezinye izinyibilikisi ezimhlophe ezifana neealkoholi (umzekelo, i-ethanol), ii-glycols (umzekelo, ipropylene glycol), okanye imixube yamanzi kunye nezinyibilikisi eziphilayo.Ukhetho luxhomekeke kwisicelo esithile kunye neempawu ezifunwayo zesisombululo.
3. Ukumisela Ugxininiso olufunekayo:
Iingqwalasela: Ugxininiso olufunekayo luxhomekeke kusetyenziso olucetywayo, njengokuqina, ukwenza ifilimu, okanye njenge-agent ebophelelayo.
I-Initial Concentration: I-HPMC ixhaphake ngokunikezelwa kwifomu ye powder kunye namabakala e-viscosity achaziweyo.Ugxininiso lokuqala luboniswa ngokuqhelekileyo kwipakethe yemveliso.
4. Amanyathelo okulungiselela:
Ukulinganisa: Ukulinganisa ngokuchanekileyo inani elifunekayo le-HPMC powder usebenzisa ibhalansi echanekileyo.
IMeasuring Solvent: Yenza umlinganiselo wesixa esifanelekileyo sesinyibilikisi (umzekelo, amanzi) esifunekayo ukuxutywa.Qinisekisa ukuba isinyibilikisi sicocekile kwaye kukhethwa ukuba sikumgangatho ofanelekileyo wesicelo sakho.
Ukukhethwa Kwesikhongozeli: Khetha isikhongozeli esicocekileyo esinokwamkela umthamo wesisombululo sokugqibela ngaphandle kokuphuphuma.
Izixhobo zokuxuba: Sebenzisa izixhobo ezishukumisayo ezifanelekileyo kumthamo kunye ne-viscosity yesisombululo.I-magnetic stirrers, ii-overhead stirrers, okanye izixube eziphathwa ngesandla zidla ngokusetyenziswa.
5. Inkqubo yokuxuba:
Ukuxutywa okubandayo: Kwi-HPMC enyibilikayo emanzini, qala ngokudibanisa isinyibilikisi esilinganisiweyo kwisitya sokuxuba.
Ukongezwa ngokuthe ngcembe: Yongeza kancinane i-HPMC powder ebekwe ngaphambili kwi-solvent ngelixa uvuselela ngokuqhubekayo ukukhusela i-clumping.
Ukuphazamiseka: Gcina ukuvuselela de i-HPMC powder ihlakazwe ngokupheleleyo kwaye akukho ziqhuma ezihlalayo.
Ixesha le-Hydration: Vumela isisombululo se-hydrate ixesha elaneleyo, ngokuqhelekileyo iiyure ezininzi okanye ubusuku bonke, ukuqinisekisa ukuchithwa okupheleleyo kunye ne-viscosity efanayo.
6. Uhlengahlengiso kunye noVavanyo:
Ukulungelelaniswa kwe-Viscosity: Ukuba kuyimfuneko, lungisa i-viscosity yesisombululo se-HPMC ngokongeza ipowder eyongeziweyo yokunyuka kwe-viscosity okanye i-solvent yokunciphisa i-viscosity.
Ukulungiswa kwe-pH: Ngokuxhomekeke kwisicelo, ukulungiswa kwe-pH kunokuba yimfuneko ngokusebenzisa izongezo ze-asidi okanye ze-alkaline.Nangona kunjalo, izisombululo ze-HPMC zihlala zizinzile kuluhlu olubanzi lwe-pH.
Uvavanyo: Yenza imilinganiselo ye-viscosity usebenzisa i-viscometers okanye i-rheometers ukuqinisekisa ukuba isisombululo sihlangabezana neenkcukacha ezifunwayo.
7. Ukugcinwa kunye nokuphatha:
Ukukhethwa Kwesikhongozeli: Dlulisa isisombululo se-HPMC esixutyiweyo kwizikhongozeli ezifanelekileyo zokugcina, kukhethwa ukuba i-opaque ukukhusela ekuvezweni kokukhanya.
Ukuleyibhelishwa: Faka iilebhile ngokucacileyo kwizikhongozeli kunye neziqulatho, ugxininiso, umhla wokulungiselela, kunye nalo naluphi na olunye ulwazi olufanelekileyo.
Iimeko Zokugcina: Gcina isisombululo kwindawo epholileyo, eyomileyo kude nelanga elithe ngqo kunye namaqondo obushushu agqithisileyo ukuthintela ukuthotywa.
Ubomi beShelf: Izisombululo ze-HPMC ngokubanzi zinozinzo oluhle kodwa kufuneka zisetyenziswe ngexesha elifanelekileyo ukuphepha ungcoliseko lwe-microbial okanye utshintsho kwi-viscosity.
8. ImiGaqo yoKhuseleko:
Izixhobo zoKhuseleko zoMntu (i-PPE): Nxiba i-PPE efanelekileyo njengeiglavu kunye nezibuko zokhuseleko xa uphethe i-HPMC powder kunye nezisombululo zokuthintela ukucaphuka kwesikhumba kunye namehlo.
Ukungena komoya: Sebenza kwindawo enomoya ococekileyo ukuze ugweme ukuphefumla iincinci zothuli ezivela kwi-HPMC powder.
Ukucoca: Coca inkunkuma ngokukhawuleza kwaye ulahle inkunkuma ngokwemigaqo yasekhaya kunye nezikhokelo zomzi-mveliso.
9. Ukusombulula ingxaki:
I-Clumping: Ukuba ii-clumps zenza ngexesha lokuxuba, kwandisa ukuphazamiseka kwaye ucinge ukusebenzisa i-arhente yokuchitha okanye ukulungelelanisa inkqubo yokuxuba.
Ukuchithwa okunganeleyo: Ukuba i-HPMC powder ayichithi ngokupheleleyo, yongeza ixesha lokuxuba okanye ukushisa (ukuba kufanelekile) kwaye uqinisekise ukuba i powder yongezwa ngokuthe ngcembe ngelixa ivuselela.
Ukuhluka kwe-Viscosity: I-viscosity engahambelaniyo ingabangela ukuxuba okungafanelekanga, imilinganiselo engachanekanga, okanye ukungcola kwi-solvent.Phinda inkqubo yokucoca ngononophelo, uqinisekise ukuba zonke iinguqu zilawulwa.
10. Iingqwalasela zeSicelo:
Uvavanyo lokuhambelana: Yenza iimvavanyo zokuhambelana nezinye izithako okanye izongezo ezisetyenziswa ngokuqhelekileyo kwisicelo sakho ukuqinisekisa uzinzo kunye nokusebenza okufunayo.
Uvavanyo lokuSebenza: Vavanya ukusebenza kwesisombululo se-HPMC ehlanjululweyo phantsi kweemeko ezifanelekileyo ukuqinisekisa ukufaneleka kwayo kusetyenziso olujoliswe kuyo.
Amaxwebhu: Gcina iirekhodi ezineenkcukacha zenkqubo yokuhlanjululwa, kubandakanywa ukuqulunqwa, amanyathelo okulungiselela, iziphumo zovavanyo, kunye naluphi na uhlengahlengiso olwenziwe.
diluting HPMC kufuna ingqalelo ngenyameko izinto ezahlukeneyo ezifana ukhetho isinyibilikisi, ukuzimisela concentration, inkqubo ukuxuba, uvavanyo, kunye nokhuseleko.Ngokulandela amanyathelo acwangcisiweyo kunye nobuchule bokuphatha obufanelekileyo, ungalungiselela izisombululo ze-HPMC ezihambelana neemfuno zakho zesicelo.
Ixesha lokuposa: Mar-29-2024