Yenziwa njani ihydroxypropylcellulose?

I-Hydroxypropylcellulose (HEC) iphuma kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zezityalo.I-HPC isetyenziswa kakhulu kumashishini ahlukeneyo afana namayeza, izinto zokuthambisa kunye nemizi-mveliso yokutya ngenxa yeempawu zayo ezibalaseleyo zokwenza ifilimu kunye nokutyeba.I-synthesis ye-hydroxypropylcellulose ibandakanya amanyathelo amaninzi kwaye inkqubo ingaba nzima.

Intshayelelo yehydroxypropylcellulose:

1. Ukusebenzisa i-cellulose njengesixhobo sokuqala:

Imithombo ephambili ye-cellulose zizinto zezityalo ezifana ne-pulp yomthi okanye ikotoni.I-Cellulose yi-polymer ehambelanayo eyenziwe ngeeyunithi ze-glucose ezidityaniswe ngamabhondi e-β-1,4-glycosidic.Inenqanaba eliphezulu lepolymerization, kunye namawaka eeyunithi zeglucose ezenza amatyathanga amade.

2. Impendulo ye-Etherification:

Ukwenziwa kwe-hydroxypropylcellulose kubandakanya ukuqaliswa kwamaqela e-hydroxypropyl kwi-cellulose backbone nge-etherification.Le mpendulo ibandakanya ukusetyenziswa kwepropylene oxide njenge-alkylating agent.

Iselulosi + ipropylene oxide → ialkali-catalyzed hydroxypropyl cellulose + by-product cellulose + propylene oxide alkali-catalyzed hydroxypropyl cellulose + by-product

Isiseko se-catalysis sibalulekile ukukhuthaza ukusabela phakathi kwamaqela e-cellulose hydroxyl kunye nepropylene oxide.Eli nyathelo lidla ngokuqhutywa phantsi kweemeko ezilawulwayo ukuze kuqinisekiswe iqondo elinqwenelekayo lokutshintshwa (DS) kwamaqela e-hydroxypropyl kwikhonkco leselulosi.

3. IHydroxypropylation:

I-Hydroxypropylation ibandakanya ukongezwa kwamaqela e-hydroxypropyl kwi-cellulose backbone.Olu hlengahlengiso lunika ukunyibilika okuphuculweyo kunye nezinye iipropathi ezinqwenelekayo kwipolymer cellulosic.Iimeko zokusabela, kubandakanywa ubushushu, uxinzelelo kunye nexesha lokuphendula, zilawulwa ngononophelo ukufezekisa iimpawu zemveliso ezifunwayo.

4. Unyango lwealkali:

Emva kwe-hydroxypropylation, unyango lwe-alkaline luhlala lusetyenziselwa ukunciphisa nayiphi na i-acidic eseleyo engcolileyo kunye nokulungelelanisa i-pH yomxube wokuphendula.Eli nyathelo libalulekile kwinkqubo elandelayo yokucoca.

5. Amanyathelo okucoca:

Emva kokusabela kwe-etherification, amanyathelo amaninzi okucoca aqhele ukwenziwa ukufumana i-high-purity hydroxypropylcellulose.La manyathelo angaquka:

Hlamba: Hlamba umxube wokuphendula ukuze ususe ii-reagents ezishiyekileyo, iimveliso eziphumayo kunye neselulosi engaphendulwanga.

Ukuhluzwa: Ukucoca kusetyenziselwa ukwahlula ubumdaka obuqinileyo kumxube wokusabela.

Ukomisa: Iselulosi emanzi yehydroxypropyl iye yomiswa ukuze kususwe nakuphi na ukufuma okushiyekileyo.

6. Ukulawulwa kobunzima bemolekyuli:

Ubunzima be-molecular of hydroxypropylcellulose bunokulawulwa ngexesha lokudibanisa ukulungelelanisa iimpawu zayo kwizicelo ezithile.Oku kuphunyezwa ngokulungelelanisa iimeko zokusabela, njengobungakanani be-reagents kunye nexesha lokuphendula.

Imveliso yemizi-mveliso:

1. Inkqubo engapheliyo okanye eqhubekayo:

Ukuveliswa kwe-hydroxypropyl cellulose kunokwenziwa kwibhetshi okanye iinkqubo eziqhubekayo.Inkqubo yebhetshi ifanelekile kwimveliso encinci, ngelixa inkqubo eqhubekayo ifaneleka ngakumbi kwimveliso enkulu.

2. Ulawulo lomgangatho:

Amanyathelo okulawula umgangatho aphunyezwa kuzo zonke izigaba zenkqubo yokuvelisa ukuqinisekisa ukuhambelana kunye nokucoceka kwemveliso yokugqibela.Iindlela zokuhlalutya ezifana nechromatography, i-spectroscopy kunye nezifundo ze-rheological zisetyenziselwa ukuvavanya iiparamitha eziphambili ezifana neqondo lokuthatha indawo, ubunzima bemolekyuli kunye nokucoceka.

Ukusetyenziswa kweSelulosi yeHydroxypropyl:

1. Ishishini lamachiza:

I-Hydroxypropylcellulose isetyenziswa ngokubanzi kumalungiselelo amayeza njenge-binder, i-disintegrant kunye ne-ejenti yokukhululwa elawulwayo.Ukuhambelana kwayo kunye noluhlu olubanzi lwamachiza kunye nokungazenzi kwayo kuyenza ibe ngumxhasi oguquguqukayo.

2. Ishishini lezithambiso:

Kwishishini lezithambiso, i-hydroxypropylcellulose isetyenziswa ekuqulunqweni kweemveliso zokhathalelo lweenwele, iikhrimu zesikhumba kunye nezinye iimveliso zokhathalelo lomntu.Iimpawu zayo zokwenza ifilimu zenza ukuba zixabiseke kwiimveliso zokunakekelwa kweenwele.

3. Ishishini lokutya:

Kwishishini lokutya, i-hydroxypropylcellulose isetyenziswa njenge-thickener kunye ne-gelling agent.Ifumaneka kwiindidi zokutya kwaye inceda ukuphucula ukuthungwa nokuzinza kwabo.

I-synthesis ye-hydroxypropylcellulose ibandakanya i-etherification ye-cellulose ngokongezwa kwamaqela e-hydroxypropyl.Ukusabela ngokuqhelekileyo kubangelwa yisiseko, kulandelwa ngamanyathelo okucoca ukufumana imveliso ecocekileyo kakhulu.Ukuveliswa kwemizi-mveliso kunokwenziwa ngebhetshi okanye iinkqubo eziqhubekayo kunye namanyathelo okulawula umgangatho ongqongqo.I-Hydroxypropylcellulose inoluhlu olubanzi lwezicelo kwi-pharmaceutical, izimonyo kunye namashishini okutya ngenxa yeempawu zayo ezizodwa kunye nokuguquguquka.Ukuphuculwa okuqhubekayo kweenkqubo zemveliso kunye nophuhliso lwezicelo ezintsha kugxininisa