IHydroxypropylmethylcellulose (HPMC) yipolymer eyenziweyo evela kwiselulosi.Njenge-thickener, emulsifier kunye ne-stabilizer, isetyenziswa kakhulu kumayeza, ukutya kunye namashishini okuthambisa.I-HPMC ikwasetyenziswa kwizinto zokwakha ezifana nesamente, udaka kunye negypsum ukuphucula ukusebenza kunye nokugcinwa kwamanzi.Kweli nqaku, siza kuxubusha ukuveliswa kwe-HPMC kunye nokusetyenziswa kwayo kumashishini ahlukeneyo.
Imveliso ye-HPMC
I-HPMC idityaniswe ngokuphendula i-cellulose nge-propylene oxide kunye ne-methyl chloride phantsi kweemeko ze-alkaline.Inkqubo ibandakanya la manyathelo alandelayo:
Inyathelo 1: Unyango lwe-alkaline ye-cellulose
I-cellulose iphathwa ngesisombululo se-caustic se-sodium hydroxide ukuyiguqula kwi-alkaline cellulose.Olu nyango lwenza amaqela e-hydroxyl e-cellulose asebenze ngakumbi, aququzelele ukusabela okulandelayo.
Inyathelo lesi-2: Ukuphendula ngePropylene oxide
Kwisinyathelo esilandelayo, i-propylene oxide yongezwa kwi-cellulose ye-alkali phantsi kokushisa okulawulwayo kunye neemeko zoxinzelelo.Ukusabela kuqhutyelwa phambi kwe-catalyst efana ne-amine ephezulu okanye i-alkali metal hydroxide.Ipropylene oxide idibana kunye namaqela e-hydroxyl yeselulosi ukwenza i-hydroxypropyl cellulose.
Inyathelo lesi-3: Ukwenziwa kweQuaternization ngeMethyl Chloride
IHydroxypropylcellulose emva koko yafakwa iquaternized kunye nemethyl chloride ukuvelisa iHPMC.Ukusabela kuqhutyelwa phantsi kweemeko ze-alkaline, kwaye iqondo le-quaternization lingalawulwa ngokulungelelanisa inani le-methyl chloride.
Isiphumo se-HPMC sahlanjwa, sahluzwa kwaye somiswa ukuze sifumane umgubo omhlophe, okhululekileyo.Iipropati ze-HPMC, ezifana ne-viscosity, i-solubility, kunye neempawu ze-gel, zinokulungiswa ngokutshintsha i-degree of substitution (DS) ye-hydroxypropyl kunye namaqela e-methyl.
Ukusetyenziswa kwe-HPMC
I-HPMC inoluhlu olubanzi lwezicelo kumashishini ahlukeneyo.Ezinye izicelo eziphawulekayo zixoxwa ngezantsi:
Ishishini lamachiza
I-HPMC isetyenziswa kakhulu kushishino loxubo mayeza njengento etyebisayo, ibhinda kunye nefilimu yangaphambili.Isetyenziswe kwi-tablet formulations ukulawula ukukhutshwa kweziyobisi.I-HPMC isebenza njengesibophelelo ngokucinezela umxube womgubo kwifomu yedosi eqinileyo.Kwakhona kuphucula ukunyibilika kunye ne-bioavailability yamachiza anganyibiliki kakuhle ngokwenza i-dispersions ezinzileyo kunye efanayo.
ishishini lokutya
I-HPMC isetyenziswa kushishino lokutya njenge-emulsifier, i-thickener kunye ne-stabilizer.Isetyenziswa ngokuqhelekileyo kwiimveliso zokubhaka, i-ayisikrimu kunye neemveliso zobisi.I-HPMC iphucula ukuthungwa kunye nokuhambelana kokutya ngokuthintela ukuhlukana kwezithako kunye nokunciphisa i-syneresis.Ikwaphucula incasa kunye nobomi beshelufa yokutya.
Ishishini lezithambiso
I-HPMC isetyenziswa kushishino lwezithambiso njenge-thickener kunye ne-emulsifier.Isetyenziswa kwiimveliso zokhathalelo lwesikhumba kunye neenwele ezifana nezithambiso, iikhrimu, iishampu kunye nezipholileyo.I-HPMC iphucula ukuthungwa kunye nokungaguquguquki kwezi mveliso kwaye ibonelela ngokufuma kunye nezibonelelo zokumisela.
ishishini lokwakha
I-HPMC isetyenziswa kushishino lokwakha njengokongeza kwisamente, udaka kunye negypsum.Iphucula ukusebenza kunye nokugcinwa kwamanzi kwezi zixhobo, ngaloo ndlela ukwandisa amandla abo kunye nokuqina.I-HPMC ikwanciphisa umngcipheko wokuqhekeka kunye nokuncipha ngexesha lokumisa.
ukuququmbela
Ukuqukumbela, i-HPMC yipolymer eguquguqukayo neguquguqukayo enezicelo kumashishini ahlukeneyo.Ilungiswa ngonyango lwe-alkali ye-cellulose, ukuphendula nge-propylene oxide, kunye ne-quaternization nge-methyl chloride.Iipropati ze-HPMC zinokulungiswa ngokutshintsha iqondo lokuthatha indawo.I-HPMC idlala indima ebalulekileyo kumashishini amayeza, ukutya, izithambiso kunye nokwakha ngokuphucula ukuthungwa, ukuhambelana kunye nokusebenza kweemveliso ezahlukeneyo.I-non-toxicity yayo kunye ne-biocompatibility yenza ukuba ibe yinto ekhuselekileyo nexabisekileyo kula mashishini.
Ixesha lokuposa: Aug-03-2023