Capsule Grade HPMC for Pharma Application

I-Hydroxypropyl methylcellulose (HPMC) i-polymer eguquguqukayo esetyenziswa ngokubanzi kwishishini lamachiza ngenxa yeempawu zayo ezizodwa ezifana ne-solubility ephezulu, i-biocompatibility, kunye ne-non-toxicity.ICapsule grade HPMC, ekwabizwa ngokuba yi-hypromellose, yenzelwe ngokukodwa ukusetyenziswa kumaqokobhe e-capsule amayeza.Kweli nqaku, siza kuxoxa ngeepropati, ukuveliswa, kunye nokusetyenziswa kwe-capsule grade HPMC.

Iipropati zeCapsule Grade HPMC

ICapsule grade HPMC yi-semi-synthetic, inert, kunye nepolima enyibilikayo emanzini ephuma kwiselulosi.Ngumgubo omhlophe ukuya kumhlophe ongenavumba, ongenancasa, kwaye okhululekileyo.Iimpawu eziphambili ze-capsule grade HPMC zezi:

I-solubility ephezulu: I-Capsule grade HPMC inyibilika ngokukhawuleza emanzini kwaye yenza izisombululo ezicacileyo.Inobushushu obuphantsi be-gelation, oku kuthetha ukuba ingenza iigels kumaqondo aphantsi.

I-non-toxicity: iCapsule grade HPMC yipolymer engeyiyo inetyhefu ekhuselekileyo ukuba isetyenziswe ngabantu.Ikwavunywe ngamaqumrhu ahlukeneyo olawulo afana ne-US FDA, i-European Pharmacopoeia, kunye ne-Japan Pharmacopoeia.

I-Biocompatibility: I-Capsule grade HPMC iyahambelana neenkqubo zebhayoloji kwaye ayibangeli nayiphi na imiphumo emibi kwimpilo yabantu.

Ukuzinza kwe-pH: I-Capsule grade HPMC izinzile kuluhlu olubanzi lwemilinganiselo ye-pH, eyenza ilungele ukusetyenziswa kwi-acidic, neutral, kunye neendawo ezisisiseko.

Iipropati zokwenza ifilimu: I-Capsule grade HPMC inokwenza ifilimu eyomeleleyo kwaye eguquguqukayo ekwazi ukumelana nokuqhekeka, ukuxobula, kunye nokwaphuka.

Iimpawu zokukhutshwa okulawulwayo: I-Capsule grade HPMC ingasetyenziselwa ukulawula ukukhutshwa kwamachiza kwigobolondo le-capsule, eyenza kube luncedo ekuphuhliseni ukukhutshwa okukhutshiweyo okwandisiweyo.

Ukwenziwa kweCapsule Grade HPMC

ICapsule grade HPMC iveliswa ngokuguqula iikhemikhali zeselulosi yendalo ngepropylene oxide kunye nemethyl chloride.Iqondo lokuthatha indawo (DS) ye-HPMC ixhomekeke kumlinganiselo wepropylene oxide ukuya kwimethyl chloride esetyenziswa ekuphenduleni.Ixabiso le-DS libonisa inani lamaqela e-hydroxyl kwi-cellulose efakwe endaweni ye-hydroxypropyl kunye namaqela e-methyl.

Capsule grade HPMC iyafumaneka kumabanga ahlukeneyo, ngokuxhomekeke viscosity yayo kunye neqondo lokuthatha indawo.I-viscosity ye-HPMC ngumlinganiselo wobunzima bayo be-molecular kunye neqondo le-polymerization.Ukuphakama kwe-viscosity, ukuphakama kwe-molecular weight and thicker solution.Iqondo lokutshintshwa limisela ukunyibilika kunye neempawu ze-gelation ze-HPMC.

Izicelo zeCapsule Grade HPMC

ICapsule grade HPMC isetyenziswa kakhulu kwishishini lamayeza ukwenza amaqokobhe e capsule.Amaqokobhe eCapsule asetyenziselwa ukugquma izinto zeziyobisi kwaye abonelele ngendlela efanelekileyo nekhuselekileyo yokuhambisa amayeza kwizigulana.Ezona zicelo ziphambili ze-capsule grade HPMC kushishino lwamayeza zezi:

Iipilisi zeVegetarian: I-Capsule grade HPMC yindlela ethandwayo kwi-gelatin capsules, ephuma kwimithombo yezilwanyana.Iicapsules zeVegetarian ezenziwe kwi-HPMC zifanelekile ukusetyenziswa kwi-vegan kunye ne-vegetarian formulations kwaye zinomlinganiselo ophantsi wokufuma, ozenza zizinze kwaye kulula ukuziphatha.

Ukuqulunqwa kokukhutshwa okulawulwayo: I-Capsule grade HPMC ingasetyenziselwa ukulawula ukukhutshwa kweziyobisi kwigobolondo le-capsule.Ireyithi yokukhutshwa kweziyobisi inokulawulwa ngokulungelelanisa i-viscosity kunye neqondo lokuthatha indawo ye-HPMC.Oku kwenza i-capsule grade HPMC ibe luncedo ekuphuhliseni imixube ekhutshiweyo eyandisiweyo enokubonelela ngonikezelo lwamachiza oluzinzileyo kwithuba lexesha.

I-Enteric-coated capsules: iCapsule grade HPMC ingasetyenziselwa ukwenza i-enteric-coated capsules, eziyilelwe ukukhulula ichiza emathunjini kunokuba isisu.I-Enteric-coated capsules iluncedo kumachiza anokuthi achaphazeleke kwimeko ye-asidi yesisu okanye abangele ukucaphuka kwi-lining yesisu.

Ukufihla incasa: ICapsule grade HPMC ingasetyenziselwa ukugquma incasa ekrakrayo yamachiza anencasa engathandekiyo.I-HPMC ingasetyenziselwa ukwenza incasa yokugquma incasa kumasuntswana echiza, nto leyo enokuphucula ukuthotyelwa kwesigulane kunye nokwamkeleka.

Ukwandiswa kokunyibilika: ICapsule grade HPMC inokuphucula ukunyibilika kwamachiza anganyibiliki kakuhle ngokwenza ukusasazwa okuqinileyo.I-HPMC ingasetyenziselwa ukugquma amasuntswana echiza kunye nokuphucula ukumanzisa kunye neempawu zabo zokutshatyalaliswa.

Umxhasi: ICapsule grade HPMC ingasetyenziswa njenge excipient kwimixube eyahlukeneyo yamayeza enjengeepilisi, i-ointments, kunye nokunqunyanyiswa.Inokuthi isebenze njenge-binder, i-disintegrant, i-emulsifier, kunye ne-stabilizer, kuxhomekeke ekuqulunqweni.

Ukuqukumbela

ICapsule grade HPMC yipolymer eguquguqukayo kwaye isetyenziswa ngokubanzi kwishishini lamayeza.Ineempawu ezizodwa ezifana ne-solubility ephezulu, i-non-toxicity, kunye ne-biocompatibility, eyenza ibe yinto efanelekileyo yokusetyenziswa kwiigobolondo ze-capsule.Inkqubo yokwenziwa komgangatho we-capsule ye-HPMC ibandakanya ukuguqulwa kweekhemikhali zeselulosi yendalo kunye nepropylene oxide kunye ne-methyl chloride ukufumana i-viscosity efunwayo kunye neqondo lokutshintshwa.I-Capsule grade HPMC ifumana izicelo ezahlukeneyo kwishishini loxubo mayeza, njengokwenza ii-capsules zemifuno, iifomsuleli ezikhutshwayo ezilawulwayo, i-enteric-coated capsules, i-taste-masking, ukuphuculwa kwe-solubility, kunye ne-excipient kwiindlela ezahlukeneyo zokuxutywa.