Kapsule Grade HPMC ya Pharma Application

Hydroxypropyl methylcellulose (HPMC) ndi polima yosunthika yomwe imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala chifukwa cha mawonekedwe ake apadera monga kusungunuka kwambiri, kuyanjana kwachilengedwe, komanso kusagwiritsa ntchito poizoni.Kapsule grade HPMC, yomwe imadziwikanso kuti hypromellose, idapangidwa kuti igwiritsidwe ntchito mu zipolopolo zamakapisozi amankhwala.M'nkhaniyi, tikambirana za katundu, kupanga, ndi ntchito kapisozi kalasi HPMC.

Katundu wa Capsule Grade HPMC

Kapisozi kalasi HPMC ndi semi-synthetic, inert, ndi madzi sungunuka polima yochokera mapadi.Ndi ufa woyera mpaka kuyera wopanda fungo, wosakoma, komanso wopanda pake.The katundu kapisozi kalasi HPMC ndi:

Kusungunuka kwakukulu: Kapsule grade HPMC imasungunuka mosavuta m'madzi ndikupanga mayankho omveka bwino.Lili ndi kutentha kwa gelation, zomwe zikutanthauza kuti zimatha kupanga ma gel pa kutentha kochepa.

Non-toxicity: Kapsule grade HPMC ndi polima wopanda poizoni yemwe ndi wotetezeka kuti anthu amwe.Imavomerezedwanso ndi mabungwe osiyanasiyana owongolera monga US FDA, European Pharmacopoeia, ndi Japan Pharmacopoeia.

Biocompatibility: Kapsule grade HPMC imagwirizana ndi machitidwe achilengedwe ndipo sizimayambitsa mavuto pa thanzi la munthu.

Kukhazikika kwa pH: Kapsule grade HPMC ndi yokhazikika pamitundu yambiri ya pH, zomwe zimapangitsa kuti zikhale zoyenera kugwiritsidwa ntchito m'malo a acidic, osalowerera ndale, komanso oyambira.

Kapangidwe ka filimu: Kapsule grade HPMC ikhoza kupanga filimu yolimba komanso yosinthika yomwe imagonjetsedwa ndi kusweka, kusenda, ndi kuthyoka.

Zotulutsa zoyendetsedwa: Kapsule grade HPMC ingagwiritsidwe ntchito kuwongolera kutulutsidwa kwa mankhwala kuchokera ku chipolopolo cha kapisozi, zomwe zimapangitsa kuti zikhale zothandiza popanga mapangidwe otulutsa nthawi yayitali.

Kupanga Capsule Grade HPMC

Kapisozi kalasi HPMC amapangidwa ndi mankhwala kusintha mapadi zachilengedwe ndi propylene okusayidi ndi methyl kolorayidi.Mlingo wa m'malo (DS) wa HPMC umadalira chiŵerengero cha propylene oxide ku methyl chloride yomwe imagwiritsidwa ntchito pochita.Mtengo wa DS ukuwonetsa kuchuluka kwa magulu a hydroxyl pa cellulose omwe asinthidwa ndi magulu a hydroxypropyl ndi methyl.

Kapisozi kalasi HPMC imapezeka m'makalasi osiyanasiyana, kutengera mamasukidwe ake akayendedwe ndi mlingo wa m'malo.The mamasukidwe akayendedwe a HPMC ndi muyeso wa maselo ake kulemera ndi digiri ya polymerization.Kuchuluka kwa viscosity, kukwezeka kwa molekyulu ndi kuchuluka kwa yankho.Mlingo wa m'malo umatsimikizira kusungunuka ndi gelation katundu wa HPMC.

Kugwiritsa ntchito Capsule Grade HPMC

Kapisozi kalasi HPMC chimagwiritsidwa ntchito makampani mankhwala kupanga kapisozi zipolopolo.Zipolopolo za makapisozi zimagwiritsidwa ntchito kuyika zinthu za mankhwala ndikupereka njira yabwino komanso yotetezeka yoperekera mankhwala kwa odwala.Ntchito zazikulu za kapisozi grade HPMC pamakampani opanga mankhwala ndi:

Makapisozi a Zamasamba: Kapsule grade HPMC ndi njira yodziwika bwino ya makapisozi a gelatin, omwe amachokera ku nyama.Makapisozi azamasamba opangidwa kuchokera ku HPMC ndi oyenera kugwiritsidwa ntchito popanga zamasamba ndi zamasamba ndipo amakhala ndi chinyezi chochepa, chomwe chimawapangitsa kukhala okhazikika komanso osavuta kugwira.

Mapangidwe otulutsidwa: Kapsule grade HPMC angagwiritsidwe ntchito kuwongolera kutulutsidwa kwa mankhwala ku chipolopolo cha kapisozi.Mlingo wa kutulutsidwa kwa mankhwala ukhoza kuwongoleredwa posintha mamasukidwe akayendedwe ndi kuchuluka kwa m'malo mwa HPMC.Izi zimapangitsa HPMC ya kapisozi kukhala yothandiza popanga zotulutsa zotalikirapo zomwe zimatha kupereka mankhwala osatha pakapita nthawi.

Makapisozi okhala ndi Enteric: Kapisozi kalasi ya HPMC angagwiritsidwe ntchito kupanga makapisozi okhala ndi enteric, omwe amapangidwa kuti atulutse mankhwalawa m'matumbo m'malo mwa m'mimba.Makapisozi okhala ndi ma Enteric ndi othandiza pamankhwala omwe amakhudzidwa ndi acidic m'mimba kapena kuyambitsa kukwiyitsa m'mimba.

Kulawa: HPMC ya kapisozi kalasi ingagwiritsidwe ntchito kubisa kukoma kowawa kwa mankhwala omwe ali ndi kukoma kosasangalatsa.HPMC ingagwiritsidwe ntchito kupanga zokutira zotsekemera pa tinthu tating'onoting'ono ta mankhwala, zomwe zingapangitse kutsata kwa odwala ndi kuvomereza.

Kupititsa patsogolo kusungunuka: Kapsule grade HPMC imatha kusungunuka bwino mankhwala osasungunuka mwa kupanga kubalalitsidwa kolimba.HPMC itha kugwiritsidwa ntchito kuvala tinthu tating'onoting'ono tamankhwala ndikuwongolera kunyowetsa ndi kusungunuka kwawo.

Excipient: kapisozi kalasi HPMC angagwiritsidwe ntchito monga excipient zosiyanasiyana mankhwala formulations monga mapiritsi, mafuta odzola, ndi suspensions.Itha kukhala ngati binder, disintegrant, emulsifier, ndi stabilizer, kutengera kapangidwe kake.

Mapeto

Kapisozi kalasi HPMC ndi zosunthika ndipo ankagwiritsa ntchito polima mu makampani mankhwala.Lili ndi zinthu zapadera monga kusungunuka kwakukulu, kusakhala ndi poizoni, ndi biocompatibility, zomwe zimapangitsa kuti zikhale zoyenera kugwiritsidwa ntchito mu zipolopolo za capsule.Kapangidwe ka kapisozi kalasi ya HPMC kumakhudzanso kusinthika kwa cellulose yachilengedwe ndi propylene oxide ndi methyl chloride kuti mupeze kukhuthala komwe mukufuna komanso kuchuluka kwa m'malo.Kapisozi kalasi HPMC amapeza ntchito zosiyanasiyana mu makampani mankhwala, monga kupanga makapisozi zamasamba, olamulira-kumasulidwa formulations, enteric- TACHIMATA makapisozi, kukoma-masking, solubility kuwongola, ndi monga excipient mu formulations zosiyanasiyana.