Marotholi a mahlo ke mokhoa oa bohlokoa oa phepelo ea meriana bakeng sa maemo a fapaneng a mahlo, ho tloha ho lefu la mahlo a omileng ho isa ho glaucoma.Katleho le polokeho ea metsoako ena e itšetlehile ka lintlha tse 'maloa, ho kenyelletsa le metsoako ea tsona.E 'ngoe ea metsoako ea bohlokoa joalo e fumanoang mekhoeng e mengata ea ho theola mahlo ke Hydroxypropyl Methylcellulose (HPMC).
1. Ho utloisisa HPMC:
HPMC ke semisynthetic, polymer e qhibilihang ka metsing e tsoang ho selulose.Ka khemikhale, ke cellulose ether moo lihlopha tsa hydroxyl tsa mokokotlo oa cellulose li nkeloang sebaka ke lihlopha tsa methyl le hydroxypropyl.Phetoho ena e ntlafatsa ho qhibiliha ha eona, biocompatibility, le botsitso, e etsa hore e tšoanelehe bakeng sa lits'ebetso tse fapaneng tsa meriana.
2.Seabo sa HPMC ho Marotholi a Mahlo:
Viscosity le Lubrication:
E 'ngoe ea mesebetsi ea mantlha ea HPMC marotholing a mahlo ke ho lokisa viscosity ea sebopeho.Ho eketsoa ha HPMC ho eketsa viscosity ea tharollo, ho thusa ho lelefatsa nako ea ho kopana le moriana ka sefahleho sa mahlo.Khokahano ena ea nako e telele e netefatsa ho monya le ho ajoa ha lithethefatsi ho betere.Ho feta moo, sebopeho sa viscous sa HPMC se fana ka lubrication, ho imolla bohloko bo amanang le maemo a mahlo a omileng le ho ntlafatsa matšeliso a mokuli ha a kenngoa.
Mucoadhesion:
HPMC e na le thepa ea li-mucoadhesive, e e nolofalletsang ho khomarela bokaholimo ba mahlo nakong ea tsamaiso.Ho khomarela sena ho lelefatsa nako ea ho lula ha meriana, ho khothalletsa ho lokolloa ho tsitsitseng le ho ntlafatsa katleho ea phekolo.Ho phaella moo, mucoadhesion e thusa ho thehoa ha mokoallo o sireletsang holim'a cornea, ho thibela ho lahleheloa ke mongobo le ho sireletsa leihlo ho tsoa linthong tse ka ntle.
Tšireletso ea Ocular Surface:
Ho ba teng ha HPMC marotholing a mahlo ho theha filimi e sireletsang holim'a sefahleho sa mahlo, ho e sireletsa ho tloha linthong tsa tikoloho tse kang lerōle, litšila le lintho tse ling.Tšitiso ena e sireletsang ha e ntlafatse matšeliso a mokuli feela empa e boetse e khothalletsa pholiso ea mahlo le nchafatso, haholo-holo maemong a ho senyeha ha cornea kapa tšenyo ea epithelial.
Phano e Ekelitsoeng ea Lithethefatsi:
HPMC e thusa ho kopanngoa le ho hasana ha lithethefatsi tse sa qhibiliheng hantle ka litharollong tse nang le metsi, ka tsela eo e matlafatsa bioavailability ea tsona le phekolo e sebetsang hantle.Ka ho etsa libopeho tse kang micelle, HPMC e kenyelletsa limolek'hule tsa lithethefatsi, ho thibela ho bokellana ha tsona le ho ntlafatsa ho senyeha ha tsona ka har'a sebopeho sa marotholi a mahlo.Sollubility ena e ntlafetseng e tiisa kabo e tšoanang ea lithethefatsi ha e kenngoa, e lebisang ho liphello tse tsitsitseng tsa phekolo.
Preservative Stabilization:
Metsoako ea ho theola mahlo hangata e na le li-preservatives ho thibela tšoaetso ea likokoana-hloko.HPMC e sebetsa e le setsi sa botsitso bakeng sa li-preservatives, ho boloka ts'ebetso ea tsona nakong eohle ea bophelo ba sehlahisoa.Ho feta moo, HPMC e fokotsa kotsi ea ho teneha ha leihlo kapa chefo ka ho theha sethibelo se sirelletsang se thibelang ho kopana ka kotloloho lipakeng tsa li-preservative le bokaholimo ba mahlo.
3.Bohlokoa ba HPMC ho Therapeutics ea Ocular:
Ho Ikamahanya le Mokuli le Mamello:
Ho kenyeletsoa ha HPMC mefuteng ea marotholi a mahlo ho ntlafatsa ho lumellana le mamello le mamello.Lintho tsa eona tse matlafatsang li-viscosity li lelefatsa nako ea ho kopana le meriana ka leihlo, ho fokotsa nako ea tsamaiso.Ho feta moo, litšoaneleho tsa ho tlotsa le tse khomarelang tsa HPMC li matlafatsa boiketlo ba mokuli, li fokotsa ho teneha le ho se utloise bohloko ho amanang le ho kenngoa ha mahlo.
Mefuta e sa tšoaneng le Tšebelisano:
HPMC e lumellana le mefuta e mengata e fapaneng ea metsoako e sebetsang ea meriana, e etsang hore e loketse ho etsa mefuta e sa tšoaneng ea marotholi a mahlo, ho akarelletsa le tharollo ea metsi, ho emisoa, le mafura.Ho feto-fetoha ha eona ho lumella hore ho behoe liforomo ho fihlela litlhoko tse khethehileng tsa kalafo tsa maemo a fapaneng a mahlo, joalo ka lefu la mahlo a omileng, glaucoma le conjunctivitis.
Safety le Biocompatibility:
HPMC e amoheloa e bolokehile ebile e lumellana le bioloji ke mekhatlo e laolang joalo ka FDA le EMA, e netefatsang hore e loketse tšebeliso ea mahlo.Sebopeho sa eona se se nang chefo le se sa khopiseng se fokotsa kotsi ea ho ba le maikutlo a mabe kapa chefo ea mahlo, ho etsa hore e tšoanelehe bakeng sa phekolo ea nako e telele le tšebeliso ea bana.Ho feta moo, HPMC e khona ho senyeha habonolo, 'me e baka tšusumetso e fokolang ea tikoloho ha e lahloa.
Hydroxypropyl Methylcellulose (HPMC) e bapala karolo ea bohlokoa ho thehoeng ha marotholi a mahlo, ho tlatsetsa ho viscosity, lubrication, mucoadhesion, ts'ireletso ea sefahleho sa mahlo, phepelo e matla ea lithethefatsi, le ho boloka botsitso.Ho kenyeletsoa ha eona mekhoeng ea ho theola mahlo ho ntlafatsa ho lumellana le mokuli, ho mamella, le katleho ea phekolo, e leng se etsang hore e be motheo oa phekolo ea mahlo.Ho feta moo, polokeho ea HPMC, biocompatibility, le ho feto-fetoha ha maemo ho totobatsa bohlokoa ba eona e le motsoako oa mantlha mekhoeng ea mahlo.Ha lipatlisiso le thekenoloji li ntse li tsoela pele, ho lebeletsoe hore ho be le mekhoa e mecha ea marotholi a mahlo a thehiloeng ho HPMC, e tšepisang liphello tse ntlafetseng tsa phekolo le liphello tsa mokuli lefapheng la ophthalmology.
Nako ea poso: Mar-09-2024