Madonhwe eziso inzira yakakosha yekuendesa mishonga yemamiriro akasiyana emeso, kubva pakaoma eye syndrome kusvika kuglaucoma.Kubudirira uye kuchengetedzeka kwezviumbwa izvi zvinoenderana nezvakawanda zvinhu, kusanganisira izvo zvinosanganisa.Chimwe chinhu chakakosha chakadaro chinowanikwa mune akawanda madonhwe ekudonha kwemaziso iHydroxypropyl Methylcellulose (HPMC).
1. Kunzwisisa HPMC:
HPMC is semisynthetic, mvura-soluble polima inotorwa kubva ku cellulose.Kemikari, ndeye cellulose ether umo hydroxyl mapoka e cellulose musana anotsiviwa ne methyl uye hydroxypropyl mapoka.Ichi chigadziriso chinowedzera kunyungudika kwayo, biocompatibility, uye kugadzikana, zvichiita kuti ive yakakodzera kune dzakasiyana siyana dzemishonga.
2.Basa reHPMC muMadonhwe Eziso:
Viscosity uye Lubrication:
Rimwe remabasa ekutanga eHPMC mumadonhwe emeso ndeyekugadzirisa viscosity yekuumbwa.Kuwedzerwa kweHPMC kunowedzera mhinduro yeviscosity, zvichibatsira mukurebesa nguva yekusangana kwemushonga nemeso emeso.Kusangana kwenguva refu uku kunoita kuti zvinodhaka zvinyunzwe zviri nani uye kugovaniswa.Zvakare, iyo viscous hunhu hweHPMC inopa lubrication, inodzora kusagadzikana kwakabatana neakaoma maziso mamiriro uye kunatsiridza nyaradzo yemurwere pakuiswa.
Mucoadhesion:
HPMC ine mucoadhesive zvivakwa, ichiigonesa kunamatira kune ocular pamusoro pekutonga.Uku kunamatira kunowedzera nguva yekugara kwemushonga, kukurudzira kusunungurwa kwakasimba uye kuwedzera kurapa kwakanaka.Pamusoro pezvo, mucoadhesion inofambisa kuumbwa kwechidziviriro chekudzivirira pamusoro pe cornea, kudzivirira kurasikirwa kwemwando uye kudzivirira ziso kubva kune kunze zvinotsamwisa.
Ocular Surface Protection:
Kuvapo kweHPMC mumadonhwe emeso kunogadzira firimu rekudzivirira pamusoro pechiso chemaziso, kuchidzivirira kubva kune zvakatipoteredza zvakaita seguruva, zvinosvibisa, uye allergens.Ichi chipingamupinyi chinodzivirira hachingowedzere kunyaradzwa kwevarwere asiwo chinokurudzira kuporesa kwemaziso uye kuberekwa patsva, kunyanya muzviitiko zvekorneal abrasions kana epithelial kukuvara.
Kufambiswa Kwezvinodhaka Kwakawedzerwa:
HPMC inogonesa kusanganiswa uye kuparadzirwa kwemishonga isinganyungudika mumigero ine mvura, nekudaro ichiwedzera bioavailability yavo uye kurapa kwakanaka.Nekugadzira micelle-senge zvimiro, HPMC inovharira mamorekuru emishonga, kudzivirira kuunganidzwa kwavo uye nekuvandudza dispersibility yavo mukati mekudonha kweziso.Uku kunyungudika kunyungudika kunovimbisa kugovaniswa kwezvinodhaka kwakafanana pakuiswa, zvichitungamira kumhedzisiro yekurapa.
Preservative Stabilization:
Madonhwe ekudonhedza maziso kazhinji ane zvinochengetedza kudzivirira kusvibiswa kwehutachiona.HPMC inoshanda semumiriri anodzikamisa kune aya anochengetedza, achichengetedza kushanda kwawo mukati mehupenyu hwesherufu yechigadzirwa.Pamusoro pezvo, HPMC inoderedza njodzi yekuchengetedza-inokonzeresa kushatirwa kwemaziso kana muchetura nekugadzira chipingamupinyi chekudzivirira chinomisa kusangana kwakananga pakati pezvidziviriro uye nzvimbo yemeso.
3.Kukosha kweHPMC muOcular Therapeutics:
Kuteerera Murwere uye Kushivirira:
Kuiswa kweHPMC mukudonha kwemaziso kunovandudza kuterera kwemurwere uye kushivirira.Yayo viscosity-enhancing properties inowedzera nguva yekubatana kwemishonga neziso, kuderedza kuwanda kwehutungamiri.Uyezve, iyo yekuzora uye mucoadhesive maitiro eHPMC anowedzera kunyaradzwa kwevarwere, kuderedza kushatirwa uye kusagadzikana kunoenderana nekuiswa kwemaziso.
Versatility uye Kuenderana:
HPMC inopindirana neyakasiyana-siyana yeanoshanda mishonga yemishonga, ichiita kuti ive yakakodzera kugadzira marudzi akasiyana-siyana emadonhwe emeso, kusanganisira mhinduro dzemvura, kumiswa, uye mafuta ekuzora.Kuita kwayo kwakasiyana-siyana kunobvumira kugadziridzwa kwemaumbirwo kuti asangane nezvinodiwa zvekurapa zveasiyana mamiriro emeso, akadai seakaoma eye syndrome, glaucoma, uye conjunctivitis.
Kuchengeteka uye Biocompatibility:
HPMC inozivikanwa seyakachengeteka uye biocompatible neanodzora masangano akadai seFDA neEMA, kuve nechokwadi kuti yakakodzera kushandiswa kwemaziso.Yayo isiri-chepfu uye isingatsamwire hunhu inoderedza njodzi yeakaipa kana huturu hwemaziso, zvichiita kuti ive yakakodzera kurapwa kwenguva refu uye kushandiswa kwevana.Pamusoro pezvo, HPMC iri nyore kuparara, ichiisa kushomeka kwemamiriro ekunze pakuraswa.
Hydroxypropyl Methylcellulose (HPMC) inoita basa rakakosha mukugadzira madonhwe eziso, zvichibatsira kuviscosity yavo, lubrication, mucoadhesion, kuchengetedzwa kwemaziso, kukwidziridzwa kwezvinodhaka, uye kuchengetedza kugadzikana.Kuiswa kwaro mumadonhwe ekudonha kweziso kunowedzera kuterera kwemurwere, kushivirira, uye kugona kwekurapa, zvichiita kuti ive dombo rekona muocular therapeutics.Zvakare, kuchengetedzwa kweHPMC, biocompatibility, uye kuita zvakasiyana-siyana kunosimbisa kukosha kwayo sechinhu chakakosha mukugadzirwa kweophthalmic.Sezvo kutsvagisa uye tekinoroji ichienderera mberi, humwe hutsva muHPMC-based madonhwe emeso anotarisirwa, achivimbisa kuvandudzwa kwemhedzisiro yekurapa uye nemhedzisiro yevarwere mumunda weophthalmology.
Nguva yekutumira: Kurume-09-2024