Mwụda anya bụ ụdị dị mkpa nke nnyefe ọgwụ maka ọnọdụ anya dị iche iche, sitere na ọrịa anya akọrọ ruo glaucoma.Ịdị irè na nchekwa nke usoro ndị a na-adabere n'ọtụtụ ihe, gụnyere ihe ndị ha na-emepụta.Otu ihe dị mkpa dị otú ahụ a na-achọta n'ọtụtụ usoro ntinye anya bụ Hydroxypropyl Methylcellulose (HPMC).
1. Ịghọta HPMC:
HPMC bụ semisynthetic, mmiri-soluble polymer sitere na cellulose.Kemịkalụ, ọ bụ cellulose ether ebe a na-eji otu methyl na hydroxypropyl dochie otu hydroxyl nke ọkpụkpụ azụ cellulose.Mgbanwe a na-eme ka ọ dịkwuo mfe, biocompatibility, na nkwụsi ike, na-eme ka ọ dabara maka ngwa ọgwụ dị iche iche.
2.Oru HPMC n'ime ndopu anya:
Viscosity na mmanu mmanu:
Otu n'ime isi ọrụ nke HPMC na anya tụlee bụ imezi viscosity nke nhazi.Mgbakwunye nke HPMC na-abawanye viscosity ngwọta, na-enyere aka ịgbatị oge kọntaktị nke ọgwụ ahụ na elu anya.Mmekọrịta ogologo oge a na-eme ka mmịnye na nkesa ọgwụ ka mma.Ọzọkwa, ọdịdị viscous nke HPMC na-enye mmanu, na-ebelata ahụ erughị ala jikọtara na ọnọdụ anya akọrọ na imeziwanye nkasi obi onye ọrịa n'elu instillation.
Mucoadhesion:
HPMC nwere ihe mgbochi mucoadhesive, na-enyere ya aka ịrapara n'elu anya mgbe nchịkwa gasịrị.Adhesion a na-agbatị oge obibi nke ọgwụ ahụ, na-akwalite ntọhapụ na-adịgide adịgide yana ịkwalite nrụpụta ọgwụgwọ.Ọzọkwa, mucoadhesion na-enyere aka ịmepụta ihe mgbochi n'elu cornea, na-egbochi mmiri mmiri ma na-echebe anya site na mgbakasị mpụga.
Nchedo elu anya:
Ọnụnọ nke HPMC na anya mmiri na-emepụta ihe nkiri nchebe n'elu anya anya, na-echebe ya pụọ na ihe ndị dị na gburugburu ebe obibi dị ka uzuzu, mmetọ, na allergens.Ihe mgbochi a na-echebe ọ bụghị nanị na-akwalite nkasi obi onye ọrịa kamakwa ọ na-akwalite ọgwụgwọ anya na mmeghari ohuru, karịsịa n'ihe gbasara abrasions nke corneal ma ọ bụ mmebi epithelial.
Nnyefe ọgwụ emelitere:
HPMC na-akwado solubilization na mgbasa nke ọgwụ na-adịghị mma soluble na ngwọta mmiri, si otú ahụ na-eme ka bioavailability ha na ọgwụgwọ ọgwụgwọ dị mma.Site n'ịmepụta ihe owuwu micelle, HPMC na-ekpuchi mkpụrụ ndụ ọgwụ, na-egbochi nchịkọta ha ma melite mgbasawanye ha n'ime nhazi anya.Solubility a kwalitere na-eme ka nkesa ọgwụ dị n'otu mgbe etinyere ya, na-eduga na nsonaazụ ọgwụgwọ na-agbanwe agbanwe.
Nkwado nchekwa:
Usoro ntinye anya na-enwekarị ihe nchekwa iji gbochie mmetọ microbial.HPMC na-eje ozi dị ka ihe nkwụsi ike maka ihe nchekwa ndị a, na-ejigide nrụpụta ha n'oge ndụ ngwaahịa a.Na mgbakwunye, HPMC na-ebelata ihe ize ndụ nke mgbakasị anya ma ọ bụ nsi na-ebute ihe nchekwa site n'ịme ihe mgbochi na-egbochi kọntaktị kpọmkwem n'etiti ihe nchekwa na elu anya.
3.Ihe HPMC dị na ọgwụgwọ anya:
Nkwenye na nnabata onye ọrịa:
Ntinye HPMC n'ime usoro ntinye anya na-eme ka nnabata onye ọrịa na nnabata.Ihe na-eme ka viscosity ya dịkwuo elu na-agbatị oge kọntaktị nke ọgwụ na anya, na-ebelata oge nchịkwa.Ọzọkwa, mmanye mmanu na mucoadhesive nke HPMC na-akwalite nkasi obi onye ọrịa, na-ebelata iwe na ahụ erughị ala jikọtara ya na instillation anya.
Nkwekọrịta na ndakọrịta:
HPMC dakọtara na ụdị ọgwụ dị iche iche na-arụsi ọrụ ike, na-eme ka ọ dabara maka ịmepụta ụdị anya mmiri dị iche iche, gụnyere ngwọta mmiri, nkwusioru na mmanụ.Ọdịiche ya na-enye ohere maka nhazi nke usoro iji gboo mkpa ọgwụgwọ kpọmkwem nke ọnọdụ anya dị iche iche, dị ka ọrịa anya akọrọ, glaucoma, na conjunctivitis.
Nchekwa na biocompatibility:
A na-amata HPMC dị ka nchekwa na ihe dị ndụ site n'aka ụlọ ọrụ nhazi dịka FDA na EMA, na-ahụ na ọ dabara maka iji anya.Ọdịdị ya na-adịghị egbu egbu na nke na-adịghị ewe iwe na-ebelata ihe ize ndụ nke mmeghachi omume ọjọọ ma ọ bụ nsị anya, na-eme ka ọ dị mma maka ọgwụgwọ ogologo oge na iji ụmụaka mee ihe.Na mgbakwunye, HPMC na-adị ngwa ngwa na-emebi emebi, na-egosipụta obere mmetụta gburugburu ebe obibi na mkpofu.
Hydroxypropyl Methylcellulose (HPMC) na-arụ ọrụ dị mkpa na nhazi nke anya mmiri, na-enye aka na viscosity ha, mmanu mmanu, mucoadhesion, nchebe elu anya, nnyefe ọgwụ emelitere, na nkwụsi ike.Ntinye ya n'usoro ntinye anya na-eme ka nnabata onye ọrịa dịkwuo mma, nnabata, na ọgwụgwọ ọgwụgwọ, na-eme ka ọ bụrụ isi nkuku na ọgwụgwọ anya.Ọzọkwa, nchekwa HPMC, ihe ndakọrịta, na ngbanwe dị iche iche na-emesi ike mkpa ya dị ka isi ihe dị na nhazi nke anya.Ka nyocha na teknụzụ na-aga n'ihu na-aga n'ihu, a na-atụ anya ihe ọhụrụ ọhụrụ na ọdịda anya dabere na HPMC, na-ekwe nkwa nsonaazụ ọgwụgwọ ka mma yana nsonaazụ onye ọrịa na ngalaba nke ophthalmology.
Oge nzipu: Mar-09-2024