Hydroxypropyl Methylcellulose (HPMC) ke polymer e sebelisoang haholo liindastering tse fapaneng, ho kenyeletsoa meriana, lijo, litlolo le kaho.E 'ngoe ea lintlha tsa bohlokoa tsa tšebeliso ea eona ke ho qhibiliha ha eona, haholo-holo metsing a batang.Sengoliloeng sena se shebana le boits'oaro ba ho solubility ha HPMC metsing a batang, ho lekola thepa ea eona, lintlha tse susumetsang ho solubility, mekhoa ea ho ntlafatsa solubility, le lits'ebetso.
Hydroxypropyl Methylcellulose (HPMC) ke semi-synthetic polymer e nkiloeng ho selulose.E sebelisoa haholo liindastering tse fapaneng ka lebaka la thepa ea eona e ikhethang, ho kenyelletsa ho tenya, ho tlama, ho etsa lifilimi le bokhoni ba ho boloka metsi.E 'ngoe ea lintlha tsa bohlokoa tse amang tšebetso ea eona ke ho qhibiliha ha eona, haholo-holo metsing a batang.Ho utloisisa boits'oaro ba ho qhibiliha ha HPMC metsing a batang ho bohlokoa bakeng sa ho ntlafatsa ts'ebeliso ea eona mafapheng a fapaneng.
1.Properties ea HPMC
HPMC e bonts'a thepa ea amphiphilic ka lebaka la boteng ba lihlopha tsa hydrophobic methyl le lihlopha tsa hydrophilic hydroxypropyl.Sebopeho sena sa amphiphilic se lumella HPMC ho sebelisana le limolek'hule tsa metsi le ho etsa tharollo e tsitsitseng.The solubility ea HPMC itšetlehile ka lintlha tse 'maloa, ho akarelletsa le boima ba molek'hule, tekanyo ea ho fetola, le mocheso.
2.Solubility ea HPMC metsing a batang
HPMC e bonts'a ho qhibiliha ho fokolang metsing a batang ha ho bapisoa le metsi a chesang.The solubility ea HPMC metsing a batang e susumetsoa ke lintlha tse kang tekanyo ea ho fetola, boima ba limolek'hule, boholo ba likaroloana, le boteng ba li-solute tse ling.Ka kakaretso, boima bo tlase ba limolek'hule le boemo bo phahameng ba ho nkela sebaka li ntlafatsa ho qhibiliha ha HPMC metsing a batang.
3.Lintho Tse Susumetsang ho Solubility
Lintlha tse 'maloa li ama ho qhibiliha ha HPMC metsing a batang, ho kenyelletsa:
Boima ba Molek'hule: Boima ba limolek'hule bo tlase HPMC e atisa ho qhibiliha habonolo metsing a batang ka lebaka la ho eketseha ha ketane.
Degree of Substitution: Maemo a phahameng a phapanyetso ea hydroxypropyl le lihlopha tsa methoxy li ntlafatsa ho qhibiliha ha HPMC ka ho eketsa hydrophilicity.
Boholo ba Particle: Boholo bo nyane bo thusa ho qhibiliha ka potlako ha HPMC metsing a batang.
Mocheso: Metsi a batang a fokotsa matla a kinetic a limolek'hule, a etsa hore a se ke a sebetsa hantle ho robeheng ha li-intermolecular bond, kahoo a fokotsa ho qhibiliha ha HPMC.
4.Methods ho Ntlafatsa Solubility
Mekhoa e fapaneng e ka ntlafatsa ho qhibiliha ha HPMC metsing a batang, ho kenyelletsa:
Pre-hydration: Ho inela HPMC pele ho metsi a batang pele o e kenya mofuteng ho ka ntlafatsa dispersibility le ho qhibiliha ha eona.
Phokotso ea Boholo ba Particle: Ho sila kapa ho etsa micronization ea likaroloana tsa HPMC ho ka eketsa sebaka sa bona sa holimo, ho khothaletsa ho qhibiliha ka potlako.
Phetoho ea Lik'hemik'hale: Ho fetola sebopeho sa lik'hemik'hale tsa HPMC ka ho tsoa ho tsona ho ka ntlafatsa ho qhibiliha ha eona metsing a batang.
Li-solubilizers: Keketso ea li-solubilizing tse kang li-surfactants kapa li-co-solvents li ka ntlafatsa ho qhibiliha ha HPMC metsing a batang.
5.Likopo tsa HPMC metsing a batang
Ho sa tsotellehe ho qhibiliha ha eona ho fokolang metsing a batang, HPMC e fumana mekhoa e fapa-fapaneng ea likopo tse hlokang hore metsi a batang a qhalane.Lisebelisoa tse ling tse tloaelehileng li kenyelletsa:
Litlhahiso tsa Meriana: HPMC e sebelisoa ka har'a litlolo tsa letlapa, li-formulation tse sa khaotseng, le matlapa a senyang ka molomo a hlokang ho qhibiliha ha metsi a batang bakeng sa tsamaiso.
Indasteri ea Lijo: HPMC e sebelisoa lihlahisoa tsa lijo tse kang lino-mapholi tsa hang-hang, lintho tsa baka, le lihlahisoa tsa lebese bakeng sa thepa ea eona e teteaneng le ea ho phunya metsing a batang.
Litlolo: HPMC e kenyelelitsoe ho litlolo tsa litlolo tse kang litlolo, litlolo, le li-gel tse hlokang ho qhalana ha metsi a batang bakeng sa ho sebelisoa habonolo.
Kaho: Linthong tsa kaho tse kang seretse, li-grouts le liphahlo tsa cementitious, HPMC e sebelisoa e le ntho e bolokang metsi, e hlokang ho qhibiliha ha metsi a batang bakeng sa ho hasana hantle.
Qetellong, ho qhibiliha ha HPMC metsing a batang ho phetha karolo ea bohlokoa ts'ebetsong ea eona ho pholletsa le indasteri e fapaneng.Le ha HPMC e bonts'a ho qhibiliha ho lekanyelitsoeng metsing a batang ha ho bapisoa le metsi a chesang, thepa ea eona e ka ntlafatsoa ka lintlha tse kang boima ba limolek'hule, tekanyo ea ho fetola, le boholo ba likaroloana.Ho utloisisa lintlha tse susumetsang ho qhibiliha ha HPMC metsing a batang ho bohlokoa bakeng sa ho etsa lihlahisoa tse sebetsang hantle le ho ntlafatsa ts'ebetso ea tsona lits'ebetsong tse fapaneng.
Nako ea poso: Apr-03-2024