Kuyini ukusetshenziswa kwe-HPMC e15?

I-Hydroxypropylmethylcellulose (HPMC) E15 iyisakhi semithi esenza izinto eziningi ezihlukahlukene futhi esisetshenziswa kaningi ekwenziweni kwemithi, izimonyo nokudla.Isuselwe ku-cellulose yemvelo, lokhu okuphuma ku-cellulose kuyathandwa ngenxa yezakhiwo zayo ezihlukile, okuhlanganisa ikhono layo lokushintsha i-viscosity yesisombululo, ukuthuthukisa amaphrofayili okukhishwa kwezidakamizwa, nokuthuthukisa ukuzinza kokwakheka.

1.HPMC E15 isingeniso:

I-Hydroxypropyl methylcellulose (HPMC):
I-HPMC i-semi-synthetic polymer etholakala ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo.Ikhiqizwa ngokuphatha i-cellulose nge-alkali bese kuba yi-propylene oxide, okuholela ekuhlanganisweni ne-hydroxypropyl kanye ne-methoxy substituents.Lokhu kuguqulwa kunikeza i-HPMC izakhiwo ezihlukile, okuyenza ifanele izinhlelo zokusebenza ezihlukahlukene.

2. I-Hydroxypropyl methylcellulose E15:

I-HPMC E15 ibhekisela ngokukhethekile ebangeni le-HPMC le-viscosity ephakathi nendawo ukuya phezulu.I-“E” ekuqokweni kwayo ikhombisa ukuthi ihambisana nezicaciso ezivezwe ku-European Pharmacopoeia.Leli banga elikhethekile livame ukusetshenziswa ekwakhiweni kwemithi ukuze kuzuzwe izici ezithile zokusebenza.

3.Izicelo zemithi:

A. Izibophezelo ekwakhiweni kwethebhulethi:
I-HPMC E15 ivamise ukusetshenziswa njengesihlanganisi ekwakhiweni kwethebhulethi.Izici zayo ezibophayo zisiza ukuhlanganisa isithako sekhemisi esisebenzayo (i-API) kanye nezinto ezisizayo ndawonye, ​​okuqinisekisa ithebhulethi ehlangene neqinile.

I-B. Matrix forming agents kumalungiselelo okukhishwa okulawulwayo:
I-HPMC E15 yenza i-matrix efana nejeli lapho ithintana namanzi, iyenze ifanele ukwakheka okulawulwayo noma okuqhubekayo.Lokhu kuqinisekisa ukukhululwa okuqhubekayo, okulawulwayo komuthi isikhathi eside, ngaleyo ndlela kuthuthukisa ukuthobela kwesiguli.

C. I-ejenti yokuhlanganisa ifilimu:
I-HPMC E15 isetshenziswa njengefilimu yangaphambili yokumboza amaphilisi namaphilisi.Ifilimu ewumphumela ivikela izidakamizwa ezicini zemvelo, ithuthukisa ukubukeka futhi yenza kube lula ukugwinya.

D. Umenzeli wokumiswa:
Ekwakhekeni komlomo owuketshezi, i-HPMC E15 isebenza njenge-ejenti emisa okwesikhashana, ivimbele ukuhla kwezinhlayiyana futhi iqinisekise ukusatshalaliswa okufanayo komuthi kulo lonke uketshezi.

E. Thickener:
Izakhiwo zayo ezishintsha i-viscosity zenza i-HPMC E15 ibe yigugu njengokujiya ekwakhiweni okuwuketshezi nokuqinile okufana namajeli nokhilimu, okusiza ukuthuthukisa ukuzinza nokusebenziseka kalula.

F. Disintegrant:
Kwezinye izimo, i-HPMC E15 ingasebenza njengenqamuki, ikhuthaze ithebhulethi ukuthi ihlehle ngokushesha ibe yizinhlayiya ezincane lapho ithintana namanzi, ikhuthaze ukukhululwa kwezidakamizwa nokumuncwa.

G. Emulsion stabilizer:
Ekwakhekeni kwezihloko ezifana nokhilimu namaloshini, i-HPMC E15 isebenza njengesiqinisi kuma-emulsion, ivimbela ukuhlukaniswa kwesigaba futhi ikhulise ukuzinza okuphelele komkhiqizo.

H. Ama-pellets aqhubekayo:
I-HPMC E15 iphinde isetshenziselwe ukukhiqiza ama-pellets okukhululwa okunwetshiwe ahlinzeka ngephrofayili yokukhishwa kwezidakamizwa elawulwayo lapho inikezwa ngomlomo.

4. Ezinye izinhlelo zokusebenza:

A. Ifomula yezimonyo:
Kwezimonyo, i-HPMC E15 isetshenziswa emikhiqizweni eyahlukene okuhlanganisa okhilimu, izinto zokuthambisa kanye namashampoo ukusiza ukuthuthukisa ukuthungwa, ukuzinza kanye nokusebenza kukonke kwamafomula.

B. Imboni yokudla:
I-HPMC E15 kwesinye isikhathi isetshenziswa embonini yokudla njenge-thickener, stabilizer noma emulsifier emikhiqizweni efana namasoso, okokugqoka kanye nezimpahla ezibhakiwe.

Imboni yezokwakha:
Embonini yezokwakha, i-HPMC E15 isetshenziswa njengesengezo emikhiqizweni esekwe kusimende ukuthuthukisa ukusebenza, ukunamathela kanye nokugcinwa kwamanzi.

I-HPMC E15 iyisisetshenziswa esiguquguqukayo nesibalulekile esinezinhlobonhlobo zezinhlelo zokusebenza, ikakhulukazi embonini yezemithi.Iqhaza layo njenge-binder, i-matrix yangaphambili, i-ejenti yokumboza ifilimu, neminye imisebenzi ehlukahlukene iyenza ibe isithako esiyinhloko ekwakhiweni kwamafomu omthamo womlomo.Ngaphezu kwemithi, ukusetshenziswa kwayo kudlulela ezimbonini zezimonyo, zokudla nezokwakha, okubonisa ukuguquguquka kwayo kanye nokubaluleka kwezinhlelo zokusebenza ezahlukene.Njengoba ucwaningo nokuthuthukiswa kulezi zindawo kuqhubeka, i-HPMC E15 kungenzeka ihlale ibambe iqhaza elibalulekile ezimbonini ezifuna amasistimu okulethwa kwezidakamizwa athuthukisiwe, ukwakheka okuzinzile nokusebenza komkhiqizo okuthuthukisiwe.