Hydroxypropylmethylcellulose (HPMC) E15 ke sesebelisoa sa meriana se feto-fetohang le se sebetsang ka mefuta-futa se nang le litšebeliso tse ngata mefuteng ea meriana, litlolo le lijo.E tsoa ho selulose ea tlhaho, motsoako ona oa selulose o tumme ka lebaka la thepa ea eona e ikhethang, ho kenyelletsa le bokhoni ba eona ba ho fetola li-viscosity tsa tharollo, ho ntlafatsa litlaleho tsa ho lokolloa ha lithethefatsi, le ho matlafatsa botsitso ba tlhahiso.
1.HPMC E15 selelekela:
Hydroxypropyl methylcellulose (HPMC):
HPMC ke semi-synthetic polymer e nkiloeng ho selulose, polima ea tlhaho e fumanehang maboteng a lisele tsa semela.E hlahisoa ka ho phekola selulose ka alkali le propylene oxide, e hlahisang metsoako e nang le hydroxypropyl le methoxy substituents.Phetoho ena e fa HPMC thepa e ikhethang, e etsa hore e tšoanelehe bakeng sa lits'ebetso tse fapaneng.
2. Hydroxypropyl methylcellulose E15:
HPMC E15 ka ho khetheha e bua ka boemo bo bohareng ho isa ho bo phahameng ba viscosity HPMC.“E” lebitsong la eona e bontša hore e lumellana le litlhaloso tse boletsoeng ho European Pharmacopoeia.Kereiti ena e khethehileng e atisa ho sebelisoa mefuteng ea meriana ho finyella litšobotsi tse itseng tsa tshebetso.
3. Lits'ebetso tsa Pharmaceutical:
A. Litlamahano tse entsoeng ka letlapa:
HPMC E15 e sebelisoa hangata joalo ka tlamahano mefuteng ea matlapa.Lintho tsa eona tse tlamang li thusa ho kopanya motsoako o sebetsang oa meriana (API) le li-excipients hammoho, ho netefatsa hore letlapa le kopane le le tšoarellang.
B. Matrix ho theha li-agents litokisetsong tse laoloang tsa tokollo:
HPMC E15 e etsa matrix e kang gel ha e kopana le metsi, e etsa hore e tšoanelehe bakeng sa litlhophiso tse laoloang kapa tse tsitsitseng tsa tokollo.Sena se netefatsa tokollo e tsitsitseng, e laoloang ea sethethefatsi ka nako e telele, ka hona ho ntlafatsa ho latela melao ea mokuli.
C. Moemeli oa ho roala lifilimi:
HPMC E15 e sebelisoa e le filimi ea pele bakeng sa ho roala letlapa le lipilisi.Filimi e hlahisoang e sireletsa lithethefatsi ho tloha linthong tsa tikoloho, e ntlafatsa ponahalo le ho nolofatsa ho metsa.
D. Moemeli oa ho emisa:
Mokelikeli o entsoeng ka molomo, HPMC E15 e sebetsa e le moemeli ea emisang, e thibelang ho emisa le ho etsa bonnete ba hore moriana o ajoa ka mokhoa o tšoanang ho pholletsa le mokelikeli.
E. Thickener:
Thepa ea eona e fetolang viscosity e etsa hore HPMC E15 e be ea bohlokoa e le motenya ka har'a lintho tse mokelikeli le tse tiileng tse kang li-gel le litlolo, ho thusa ho ntlafatsa botsitso le boiketlo ba tšebeliso.
F. Disintegrant:
Litlhahlobong tse itseng, HPMC E15 e ka sebetsa joalo ka disintegrant, e khothalletsa letlapa hore le senyehe ka potlako ka likaroloana tse nyane ha le kopana le metsi, le khothalletsa ho lokolloa ha lithethefatsi le ho monya.
G. Emulsion stabilizer:
Ka li-topical formulations tse kang litlolo le litlolo, HPMC E15 e sebetsa e le stabilizer ka emulsions, ho thibela ho arohana ha mekhahlelo le ho eketsa botsitso ba sehlahisoa.
H. Li-pellets tsa ho lokolloa tse tsitsitseng:
HPMC E15 e boetse e sebelisoa ho hlahisa li-pellets tsa tokollo tse telele tse fanang ka profil e laoloang ea tokollo ea lithethefatsi ha e tsamaisoa ka molomo.
4. Lisebelisoa tse ling:
A. Cosmetic formula:
Ho litlolo, HPMC E15 e sebelisoa lihlahisoa tse fapaneng ho kenyelletsa litlolo, litlolo le li-shampoo ho thusa ho ntlafatsa sebopeho, botsitso le ts'ebetso ka kakaretso ea liforomo.
B. Indasteri ea lijo:
Ka linako tse ling HPMC E15 e sebelisoa indastering ea lijo e le setenya, se tsitsitseng kapa se emulsifier lihlahisoa tse joalo ka lisoso, liaparo le thepa e halikiloeng.
C.Indasteri ea kaho:
Indastering ea kaho, HPMC E15 e sebelisoa e le tlatsetso lihlahisoa tse thehiloeng ho samente ho ntlafatsa ts'ebetso, ho khomarela le ho boloka metsi.
HPMC E15 ke mothusi ea sebetsang ka bongata le ea bohlokoa haholo ka mefuta e mengata ea likopo, haholo indastering ea meriana.Karolo ea eona ea ho kopanya, matrix ea pele, moemeli oa ho roala filimi, le mesebetsi e meng e fapaneng e e etsa motsoako oa mantlha mekhoeng ea liforomo tsa litekanyetso tsa molomo.Ho phaella ho meriana, tšebeliso ea eona e fetela ho litlolo, lijo le indasteri ea kaho, e bontšang ho ikamahanya le maemo le bohlokoa ba eona lits'ebetsong tse fapaneng.Ha lipatlisiso le nts'etsopele libakeng tsena li ntse li tsoela pele, HPMC E15 e kanna ea lula e le karolo ea bohlokoa indastering e batlang mekhoa e ntlafalitsoeng ea phano ea lithethefatsi, litlhophiso tse tsitsitseng le ts'ebetso e ntlafalitsoeng ea sehlahisoa.
Nako ea poso: Feb-06-2024