I-HPMC yelula kanjani ukukhululwa kwezidakamizwa?

IHydroxypropyl methylcellulose (HPMC) iyi-polymer yokwenziwa esetshenziswa kakhulu embonini yezemithi ukulawula ukukhishwa kwezidakamizwa.I-polymer engeyona i-ionic, encibilika emanzini eyenza ijeli phambi kwamanzi.I-HPMC isetshenziselwa ukuguqula izinga lokukhululwa kwezidakamizwa kumafomu omthamo, njengamaphilisi, amaphilisi, kanye nokumiswa okwesikhashana.Ibuye isetshenziswe njenge-binder, disintegrant, kanye ne-lubricant ekwenzeni amaphilisi namaphilisi.

I-HPMC isebenza ngokwakha i-matrix yejeli ezungeze izinhlayiya zomuthi.Le matrix yejeli i-semi-permeable, okusho ukuthi ivumela amanzi ukuthi adlule kuyo, kodwa hhayi izinhlayiya zomuthi.Njengoba amanzi edlula ku-matrix yejeli, ancibilikisa kancane izinhlayiya zomuthi, azikhiphele endaweni ezungezile.Le nqubo yaziwa ngokuthi ukukhishwa okulawulwa yi-diffusion.

Izinga lokukhishwa okulawulwa ukusabalalisa lingalawulwa ngokulungisa izakhiwo ze-matrix yejeli ye-HPMC.Isibonelo, i-viscosity ye-matrix yejeli inganyuswa ngokungeza i-HPMC eyengeziwe, ezonciphisa izinga lokukhululwa okulawulwa ngokusakazwa.Usayizi wezinhlayiya zomuthi nawo ungalungiswa, njengoba izinhlayiya ezincane zizosakazeka ngokushesha kunezinhlayiya ezinkulu.

Ngaphezu kokulawula izinga lokukhishwa kwezidakamizwa, i-HPMC futhi inezinye izici ezizuzisayo.Ayinabuthi, ayicunuli, futhi ayiyona i-allergenic, okwenza kuphephe ukusetshenziswa ekwenziweni kwemithi.Futhi akuyona i-hygroscopic, okusho ukuthi ayitholi umswakama ovela emvelweni, okusiza ukugcina ukuzinza kokubunjwa.

I-HPMC iyithuluzi elisebenzayo lokulawula izinga lokukhululwa kwezidakamizwa.Ngokulungisa izici ze-matrix yejeli ye-HPMC, izinga lokukhishwa okulawulwa ukusakazeka kungalungiselelwa ukuhlangabezana nephrofayela yokukhishwa efiswayo.Lokhu kuvumela ukuthuthukiswa kokwakheka okukhulula izidakamizwa ngenani elilawulwayo esikhathini eside.