HPMC inowedzera sei kuburitswa kwezvinodhaka?

Hydroxypropyl methylcellulose (HPMC) i polymer yekugadzira iyo inoshandiswa zvakanyanya muindasitiri yemishonga kudzora kuburitswa kwezvinodhaka.Iyo isiri-ionic, mvura-inonyungudika polima inoumba gel pamberi pemvura.HPMC inoshandiswa kugadzirisa kuburitswa kwemishonga kubva kumafomu emuyero, senge mahwendefa, macapsules, uye kumiswa.Inoshandiswawo sebinder, disintegrant, uye lubricant mukugadzirwa kwemapiritsi nemakapisi.

HPMC inoshanda nekugadzira gel matrix yakatenderedza zvimedu zvemushonga.Iyi gel matrix ndeye semi-permeable, zvichireva kuti inobvumira mvura kupfuura nayo, asi kwete mishonga yemishonga.Sezvo mvura ichipfuura nepakati pejeri matrix, inonyungudutsa zvishoma nezvishoma mishonga yemishonga, ichiisunungura munzvimbo yakapoteredza.Iyi nzira inozivikanwa seye diffusion-controlled release.

Mwero wekusunungurwa-inodzorwa kusunungurwa kunogona kudzorwa nekugadzirisa zvimiro zveHPMC gel matrix.Semuenzaniso, viscosity yegel matrix inogona kuwedzerwa nekuwedzera HPMC yakawanda, iyo inoderedza chiyero chekupararira-kunodzorwa kusunungurwa.Hukuru hwezvimedu zvemushonga hunogonawo kugadziriswa, sezvo zvidimbu zvidiki zvichapararira nekukurumidza kupfuura zvimedu zvakakura.

Pamusoro pekudzora kuburitswa kwezvinodhaka, HPMC inewo zvimwe zvinobatsira zvinhu.Haina-chepfu, isingatsamwisi, uye isiri-allergenic, zvichiita kuti zvive zvakachengeteka kushandiswa mumishonga yemishonga.Iyo hainawo-hygroscopic, zvinoreva kuti haitore unyoro kubva kune zvakatipoteredza, iyo inobatsira kuchengetedza kugadzikana kwekugadzirisa.

HPMC chishandiso chinoshanda chekudzora kuburitswa kwezvinodhaka.Nekugadzirisa zvimiro zveHPMC gel matrix, chiyero chekupararira-chinodzorwa kusunungurwa chinogona kugadzirwa kusangana neinodiwa kuburitswa mbiri.Izvi zvinobvumira kugadzirwa kwezvakagadzirwa zvinosunungura mishonga pamwero wakadzorwa pane imwe nguva yakareba.