I-CMC Elawulwa ukusetshenziswa kokwelapha

I-CMC (i-carboxymethylcellulose) i-polymer encibilikayo emanzini, esetshenziswa kabanzi njenge-excipient embonini yezemithi.Itholakala ku-cellulose, i-polysaccharide eyenzeka ngokwemvelo, ngokwengeza amaqembu e-carboxymethyl esakhiweni sayo.I-CMC yaziwa ngezakhiwo zayo ezinhle kakhulu zokwakha ifilimu nokujiya, okuyenza ibe isithako esisebenza ngezindlela eziningi nesibalulekile ekwenziweni kwemithi eminingi.

Kwezemithi, i-CMC ivamise ukusetshenziswa njenge-thickener, stabilizer, kanye ne-lubricant.Njenge-thickener, i-CMC isetshenziswa ezinhlobonhlobo zokwakheka, okufana nokhilimu, izinto zokuthambisa, namajeli, ukuze kuhlinzekwe i-viscosity futhi kuthuthukiswe ukuthungwa kwazo.Lokhu kusiza ukuthuthukisa ukuzinza nokuvumelana komkhiqizo, okwenza kube lula ukuwufaka futhi kube mnandi ezigulini ukuwusebenzisa.I-CMC iphinde isetshenziswe njengesiqinisi ekumisweni kanye nama-emulsions, okusiza ukuvimbela izinhlayiya ukuthi zingahlali futhi ziqinisekise ukuthi umkhiqizo uhlala ufana.Ngaphezu kwalokho, i-CMC isetshenziswa njengesithambisi ekwakhiweni kwethebhulethi nama-capsule, okusiza ukuthuthukisa ukugeleza kwawo kanye nokugwinya kalula.

Olunye lwezinhlelo zokwelapha ezivame kakhulu ze-CMC lusekwakheni kwamehlo.I-CMC isetshenziswa kumaconsi wamehlo nasezinyembezini zokwenziwa ukuze kuhlinzekwe ukugcotshwa nokudambisa izimpawu zamehlo omile.Iso elomile yisimo esivamile esenzeka lapho amehlo enganikeli izinyembezi ezanele noma lapho izinyembezi zihwamuka ngokushesha.Lokhu kungase kubangele ukucasuka, ububomvu, nokungakhululeki.I-CMC iyindlela yokwelapha ephumelelayo yeso elomile ngoba isiza ukuthuthukisa ukuzinza nokugcina isikhathi sefilimu yezinyembezi endaweni ye-ocular, ngaleyo ndlela kunciphisa ukoma nokucasuka.

Ngaphezu kokusetshenziswa kwayo ekwakhiweni kwamehlo, i-CMC iphinde isetshenziswe kweminye imithi yomlomo ukuze kuthuthukiswe ukunyibilika kwayo nezinga lokubola.I-CMC ingasetshenziswa njenge-disintegrant kumaphilisi, ukuwasiza ukuba aphule ngokushesha emgudwini wamathumbu futhi athuthukise i-bioavailability yesithako esisebenzayo.I-CMC ingasetshenziswa futhi njengesihlanganisi ekwakhiweni kwethebulethi kanye nama-capsule, okusiza ukubamba izithako ezisebenzayo ndawonye futhi kuthuthukise ukuminyana kwazo.

I-CMC iyisamukeli esamukelwa kabanzi embonini yezemithi futhi ilawulwa ama-ejensi ahlukahlukene alawula izidakamizwa emhlabeni jikelele.E-United States, i-FDA (Food and Drug Administration) ilawula i-CMC njengesithako sokudla nanjengesithako esingasebenzi emithini.I-FDA isungule imininingwane yekhwalithi nobumsulwa be-CMC esetshenziswa kwezemithi futhi ibeke amazinga aphezulu okungcola nezincibilikisi eziyinsalela.

E-European Union, i-CMC ilawulwa yi-European Pharmacopoeia (Ph. Eur.) futhi ifakwe ohlwini lwezinto ezisizayo ezingasetshenziswa emikhiqizweni yokwelapha.I-Ph. Eur.iphinde yasungula izincazelo zekhwalithi nobumsulwa be-CMC esetshenziswa kwezemithi, okuhlanganisa imikhawulo yokungcola, izinsimbi ezisindayo, nezincibilikisi eziyinsalela.

Sekukonke, i-CMC idlala indima ebalulekile ekwenziweni kwemithi eminingi futhi isetshenziswa ezinhlelweni zokwelashwa ezahlukahlukene.Ukujiya kwayo okuhle kakhulu, ukunzinzisa, kanye nezindawo zokugcoba kuyenza ibe isakhi esiguquguqukayo esingasetshenziswa ezinhlobonhlobo zokwakheka.Njengesithako esilawulwayo, izinkampani zemithi zingathembela ku-CMC ukuthi iphephe, isebenze kahle, futhi ibe nekhwalithi ephezulu ekwenziweni kwazo.