Ni akọkọ, abbreviation English ti awọn ohun elo iranlọwọ
MC: Methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
fila: Cellulose acetate phthalates
HPMCP: hydroxypropyl cellulose phthalates
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: iṣuu soda carboxymethyl cellulose
MCC: Microcrystalline cellulose
PVP: Povidone
PEG: polyethylene glycol
PVA: Polyvinyl oti
Cms-na: iṣuu soda carboxymethyl sitashi
PVPP: Cross-ti sopọ povidone
CCNa: iṣuu soda carboxymethyl cellulose crosslinked
Meji, lilo diẹ ninu awọn ohun elo iranlọwọ
1. Lactose: tabulẹti: filler, paapa powder taara tabulẹti kikun;Abẹrẹ: idaabobo lyophilized
2. Microcrystalline cellulose: tabulẹti: lulú taara titẹ kikun tabulẹti;"Alemora ti o gbẹ";Awọn tabulẹti ti o ni 20% microcrystalline cellulose ṣiṣẹ bi awọn disintegrators
3. Methyl cellulose: tabulẹti: alemora;Aṣoju idadoro: iranlowo idadoro;O lọra (dari) igbaradi itusilẹ: ohun elo egungun gel hydrophilic (alailagbara)
4 iṣuu soda carboxymethyl cellulose: awọn tabulẹti: alemora;Aṣoju idadoro: iranlowo idadoro;O lọra (dari) igbaradi itusilẹ: ohun elo egungun gel hydrophilic
5. Ethyl cellulose: tabulẹti: alemora (inoluble ninu omi);O lọra (dari) igbaradi itusilẹ: ohun elo egungun tabi ohun elo iṣakoso awo awọ;Pipin ti o lagbara: ohun elo ti ngbe insoluble
6 hydroxypropyl cellulose: tabulẹti: alemora, fiimu ti a bo ohun elo;Aṣoju idadoro: iranlowo idadoro;Igbaradi itusilẹ ti o lọra (dari): ohun elo egungun jeli hydrophilic, ohun elo awo-ara microporous ti a bo dì pore-inducing oluranlowo
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose): tabulẹti: alemora, ohun elo ti a bo fiimu;Aṣoju idadoro: iranlowo idadoro;Igbaradi itusilẹ ti o lọra ati iṣakoso: ohun elo egungun jeli hydrophilic, ohun elo ti o ni awọ ara microporous ti a bo dì pore-inducing
8. Cellulose acetate phthalates: ohun elo inu
9. Hydroxypropyl cellulose phthalates: ohun elo inu
10. Hydroxypropyl cellulose acetate succinate: ohun elo inu
11. Polyvinyl phthalate (PVAP): ohun elo inu
12. Styrene Maleic acid copolymer (StyMA): ohun elo ifokan
13. Akiriliki resini (enteric type I, II, III), Eudragit L, Eudragit S (nigbakugba Eudragit L100 tabi Eudragit S 100): ohun elo inu
14.Eudragit RL, Eudragit RS: Ohun elo ti ngbe insoluble
15.Eudragit E (deede si akiriliki IV): ohun elo polima ti o ni iyọ ti inu
16. Cellulose acetate: ohun elo insoluble omi, le ṣee lo fun ti a bo tabi igbaradi ti awọn tabulẹti fifa osmotic
17. Polyvinylpyrrolidone (povidone PVP): awọn tabulẹti: adhesives;Tabulẹti: inu ohun elo ti a bo fiimu tiotuka;Pellets: nifedipine pellets (pipade to lagbara);Aṣoju idadoro: iranlowo idadoro;
Itupalẹ to lagbara: ohun elo ti ngbe omi-tiotuka;O lọra (dari) igbaradi itusilẹ: ohun elo egungun colloid hydrophilic;O lọra (dari) igbaradi itusilẹ: oluranlowo pore-inducing ni awọn tabulẹti ti a bo awo awọ microporous
18. Polyvinyl oti: film oluranlowo: film lara ohun elo, idadoro iranlowo
19. Sodium carboxymethyl sitashi: tabulẹti: disintegrating oluranlowo
20. Cross-ti sopọ povidone: Tablet: disintegrant
21. Crosslinked sodium carboxymethyl cellulose: tabulẹti: disintegrating oluranlowo
22. Low-rọpo hydroxypropyl cellulose: Tabulẹti: disintegrant
23. Polylactic acid: ohun elo polymer biodegradable, ti a lo fun igbaradi ti microspheres, awọn ẹwẹ titobi, ati bẹbẹ lọ
24. Glycerol (sorbitol propylene glycol ṣiṣẹ diẹ sii ni pẹkipẹki glycerol)
Awọn igbaradi omi: epo, epo abẹrẹ, iranlowo idadoro, moisturizer
Plasticizer ni kapusulu ati ohun elo ti a bo
Awọn ikunra, awọn ọna gbigbe transdermal: awọn olupolowo ilaluja
Ṣe alekun wettability ti awọn oogun hydrophobic, olutọsọna titẹ osmotic ni emulsion ọra inu iṣan.
Gelatin Glycerin (fun awọn ikunra, awọn suppositories, awọn pipinka to lagbara)
25. Glycerin gelatin
Sisọ awọn ìşọmọbí: omi-tiotuka matrix
Suppository: omi-tiotuka matrix
ikunra: Omi tiotuka matrix
26. Sodium dodecyl sulfate (anionic surfactant)
Emulsions, ikunra: emulsifiers
Aṣoju ọrinrin fun awọn igbaradi to lagbara / lubricant fun awọn tabulẹti
solubilizer
27. Polyethylene glycol (PEG)
Awọn tabulẹti: Omi-ipara-olomi (PEG 4000, 6000)
Tabulẹti: Plasticizer ni iwe ilana ti a bo fiimu
Kapusulu: Kapusulu rirọ ti kii-olomi alabọde (PEG 400)
Awọn ìşọmọbí sisọ silẹ: Matrix ti omi-tiotuka (PEG 4000, 6000,9300)
Suppository: suppository matrix
Aerosol: Omi-itumọ (PEG 400, 600)
Abẹrẹ: Solvent (PEG 400, 600)
Igbaradi olomi: Solvent (PEG 400, 600)
Ri to pipinka: ti ngbe
O lọra (dari) igbaradi itusilẹ: oluranlowo pore-inducing ni awọn tabulẹti ti a bo awo awọ microporous
Igbaradi gbigba percutaneous: imudara gbigba gbigbe transdermal
28. Poloxam (” zwitterionic “surfactant) A ṣọra comrade woye a discrepancy nibi, bayi atunse si” Poloxam “ti kii-ionic surfactant, ko zwitterionic surfactant!
Ti ngbe pipinka ri to, matrix suppository, emulsifier fun abẹrẹ tabi idapo
Akopọ ti apakokoro ati awọn aṣoju bacteriostatic
Hydroxyl benzene ester (neper goolu), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (titun mọ jade), benzalkonium kiloraidi (jie er kú), chlorhexidine acetate, benzyl oti (irora agbegbe) ni akoko kanna, agbelebu. pẹlu ọti butyl mẹta (irora agbegbe) ni akoko kanna, nitrobenzene, mercury, thimerosal, net disinfection, ortho-phenyl phenol, phenoxyethanol, epo eucalyptus, epo eso igi gbigbẹ oloorun, epo peppermint, ati bẹbẹ lọ.
Mẹrin, ọna sterilization
1 / Abẹrẹ glukosi, emulsion sanra fun abẹrẹ inu iṣọn, dextran, idapo kiloraidi iṣuu soda, plug roba ati sterilization gbigbona miiran;
2/ Vitamin C abẹrẹ, procaine hydrochloride injection, cortisone acetate injections, chloramphenicol oju silė ti a sterilized nipa nya kaakiri;
3 / epo abẹrẹ, matrix girisi, ampoule lilo ọna sterilization ooru gbigbẹ;
4 / Afẹfẹ yara Asepsis, oju tabili ti n ṣiṣẹ: ọna sterilization ultraviolet tabi ọna fumigation gaasi;
5/ Ọwọ, ohun elo aseptic: ọna sterilization kemikali
6/ Abẹrẹ insulin ati awọn ọja ti ibi-ara miiran: ọna sterilization sisẹ
V. Awọn idogba ti o jọmọ
1. Noyes-whitney idogba: ṣapejuwe oṣuwọn itusilẹ ti awọn oogun to lagbara.
2. Lominu ni ojulumo ọriniinitutu ti adalu
hygroscopicity ti P68 lulú)
3. Rirọpo owosuppository P87)
4.Poiseuile agbekalẹ: ṣe apejuwe awọn okunfa ti o ni ipa ti sisẹ (abẹrẹ P124)
5. Iṣiro agbekalẹ ti isotonic ilana nipa didi ojuami sokale ọnaabẹrẹ P156)
6. Isiro ti HLB iye ti adalu surfactantomi P178)
Ti o yẹ igbaradi ọna ẹrọ
1. Microcapsule: ọna condensation (nikan, eka), ọna ti ko ni iyọda, ọna iwọn otutu iyipada, ọna gbigbe omi, ọna gbigbe gbigbẹ, ọna fifun sokiri, ọna idaduro afẹfẹ, ọna imudani wiwo, ọna crosslinking radiation
2. Apapo ifisi: ọna ojutu olomi ti o kun, ọna lilọ, ọna gbigbe didi, ọna gbigbẹ fun sokiri
3. Awọn pipinka ti o lagbara: ọna gbigbẹ, ọna ti o ni iyọdajẹ, iyọdajẹ - ọna gbigbẹ, epo - ọna gbigbẹ fun sokiri, ọna lilọ
4. Liposomes: ọna abẹrẹ, ọna pipinka fiimu tinrin, ọna pipinka ultrasonic, ọna ọna evaporation alakoso, di ọna gbigbe.
5. Microspheres: emulsification - ọna itọju, ọna gbigbe gbigbẹ, ọna gbigbe omi
6. Nanoparticles: polymerization micellar, polymerization emulsion, polymerization interfacial, ọna gbigbẹ omi
7. Pellet: ọna granulation farabale, ọna granulation fun sokiri, ọna ikoko ti a bo, ọna sphericity extrusion, ọna centrifugal projectile, ọna gbigbe omi
8 suppository: ọna yo gbona, ọna titẹ tutu, ọna kneading
9. Ikunra: ọna lilọ, ọna yo, ọna emulsification
Aṣoju fiimu 10: ọna iṣelọpọ ṣiṣan slurry isokan, ọna dida fiimu titẹ, ọna ṣiṣe fiimu apapo
Meje, awọn ẹya ẹrọ aṣoju
1. Microcapsule: gelatin - Arabic gomu
2. ifisi agbo: cyclodextrin
3. ri to pipinka: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Microspheres: gelatin, albumin, PLA, ati be be lo
6. Suppository: koko bota
7. Ikunra: Epo epo, ati bẹbẹ lọ
8 film oluranlowo: PVA
Mẹjọ, igba diẹ
1. Apoule ti a ti sọ di mimọ yẹ ki o fi silẹ fun ko ju wakati 24 lọ;
2. Ibi ipamọ omi fun abẹrẹ ko gbọdọ kọja wakati 12;
3. Sterilization ti awọn abẹrẹ gbogbogbo yoo pari laarin awọn wakati 12 lẹhin ikoko;
4. Idapo ati igbaradi ojutu yoo pari laarin awọn wakati 4 ti sterilization
9. Awọn ohun ayewo didara ti o ni ibatan si awọn igbaradi oogun
1. Awọn tabulẹti: awọn abuda irisi;Iyatọ iwuwo gige;Lile ati brittleness;Ijẹrisi ti o tuka;Itusilẹ tabi itusilẹ;Isokan ti akoonu
2. Aṣoju ti n tuka: iṣọkan;Ọrinrin.Iyatọ opoiye ikojọpọ;Ayẹwo ilera;Ayẹwo granularity
3. Granule: irisi;Iwọn patiku;Pipadanu iwuwo gbigbẹ;Yo;Iyatọ fifuye
4. Capsule: irisi;Ọrinrin.Iyatọ opoiye ikojọpọ;Iyapa ati itusilẹ.
5. Awọn oogun sisọ silẹ: iyatọ iwuwo;Ayewo iye akoko itu, ati bẹbẹ lọ.
6. Suppository: irisi;Iyatọ ni iwuwo;Iwọn akoko yo;Iwọn aaye yo;Idanwo itu inu fitiro ati idanwo gbigba inu vivo
7. Pilasita: iwọn patiku;Awọn fifuye;Idiwọn makirobia;Awọn akoonu oogun akọkọ;Awọn ohun-ini ti ara;Imudara;Iduroṣinṣin;Tu silẹ, ilaluja ati gbigba awọn oogun ni ikunra.
8. Awọn abulẹ transdermal: iyatọ iwuwo;Iyatọ agbegbe;Iṣọkan ti akoonu;Ipele idasilẹ, ati bẹbẹ lọ.
10. O yatọ si itumo
1. Kapusulu Micro: o jẹ kapusulu kekere ti o ṣẹda nipasẹ fifipalẹ oogun to lagbara tabi omi bibajẹ (ti a npe ni mojuto capsule) ninu ohun elo adayeba tabi ohun elo polima sintetiki (ti a npe ni ohun elo capsule).1-5000 microns
2. Pellet: n tọka si nkan ti iyipo pẹlu iwọn ila opin ti o kere ju 2.5mm ti o wa ninu awọn oogun ati awọn ohun elo.
3. Microsphere: a skeleton-Iru airi ohun iyipo nkankan akoso nipa dissolving tabi dispersive oloro ninu awọn ilana ti polima ohun elo, pẹlu kan patiku iwọn maa laarin 1 ati 250μm.
4. Nanoparticles: awọn patikulu colloidal ti o lagbara ti o ni awọn ohun elo polymeric, pẹlu iwọn patiku ni ibiti o ti 10 ~ 1000nm.
5. Sisọ egbogi oluranlowo: ntokasi si ri to tabi omi bibajẹ oloro ati yẹ oludoti (gbogbo mọ bi matrix) alapapo yo mix, ju sinu miscible condensate, isunki condensation ati ki o ṣe ti kekere pellet igbaradi.
Akoko ifiweranṣẹ: Oṣu Kẹsan-09-2022