Yintoni ihydroxypropyl methylcellulose efakwe endaweni ephantsi?

I-Low-substituted hydroxypropylmethylcellulose (L-HPMC) i-polymer eguquguqukayo, eguquguqukayo kunye nezicelo kumashishini ahlukeneyo, kubandakanywa amayeza, ukutya, ukwakhiwa, kunye nezithambiso.Le khompawundi ivela kwi-cellulose, i-polymer yendalo efumaneka kwiindonga zeeseli zesityalo.Ukuze uqonde i-hydroxypropyl methylcellulose ephantsi endaweni, umntu kufuneka aphule igama layo kwaye ahlolisise iimpawu zayo, ukusetyenziswa, ukudibanisa, kunye nefuthe kumashishini ahlukeneyo.

1. Ukuqonda amagama:

IHydroxypropyl methylcellulose (HPMC):

I-Cellulose yi-carbohydrate eyinkimbinkimbi eyenziwe ngeeyunithi ze-glucose kwaye iyona nxalenye ephambili yeendonga zeeseli zesityalo.

IHydroxypropyl methylcellulose luhlobo olulungisiweyo lweselulosi eye yaphathwa ngokwekhemikhali ukwazisa amaqela e-hydroxypropyl kunye ne-methyl.Olu tshintsho longeza ukunyibilika kwayo kunye nezinye izinto ezinqwenelekayo.

Ufakelo oluphantsi:

Ibhekisa kwiqondo elisezantsi xa kuthelekiswa nezinye izinto eziphuma kwiselulosi, ezifana nezinto eziphuma endaweni ephezulu ezifana ne-hydroxyethyl cellulose (HEC).

2. Ukusebenza:

Ukunyibilika:

I-L-HPMC inyibilika ngakumbi emanzini kuneselulosi.

Viscosity:

I-viscosity yezisombululo ze-L-HPMC inokulawulwa ngokulungelelanisa iqondo lokutshintshwa, okwenza ukuba ilungele uluhlu olubanzi lwezicelo.

Ukwenziwa kwefilimu:

I-L-HPMC inokwenza iifilimu ezibhityileyo, iyenze ibe luncedo kwiintlobo ngeentlobo zezicelo zokugquma.

Uzinzo lweThermal:

I-polymer ngokuqhelekileyo ibonisa ukuzinza okulungileyo kwe-thermal, igalelo kwi-versatility yayo kwiinkqubo ezahlukeneyo.

3. Ukudibanisa:

Etherification:

I-synthesis ibandakanya i-etherification ye-cellulose kunye ne-propylene oxide ukwazisa amaqela e-hydroxypropyl.

I-methylation elandelayo kunye ne-methyl chloride yongeza amaqela e-methyl kumqolo we-cellulose.

Umgangatho wokutshintshwa unokulawulwa ngexesha lokudibanisa ukufumana iipropati ezifunwayo.

4. Isicelo:

A. Ishishini lamachiza:

Izibophelelo kunye needisintegrants:

Isetyenziswa njengesibophelelo kwimiqulu yethebhulethi ukubopha izithako kunye.

Isebenza njenge-disintegrant ukukhuthaza ukuchithwa kwamacwecwe kwinkqubo yokugaya.

Ukukhutshwa okuzinzileyo:

I-L-HPMC isetyenziswa kwimixube elawulwayo yokukhutshwa, evumela ichiza ukuba likhutshwe kancinci kancinci ekuhambeni kwexesha.

Amalungiselelo asemxholweni:

Ifunyenwe kwi-creams, i-gel kunye ne-ointments, inika i-viscosity kwaye iphucula ukusasazeka kweefomyula.

B. Ishishini lokutya:

Thickener:

Yandisa i-viscosity yokutya kwaye iphucula ukuthungwa kunye ne-mouthfeel.

isizinzi:

Ukwandisa ukuzinza kwe-emulsions kunye nokumiswa.

Ukwenziwa kwefilimu:

Iifilimu ezityiwayo zokupakisha ukutya.

C. Ushishino lokwakha:

Udaka kunye nesamente:

Isetyenziswa njengearhente yokugcina amanzi kwizinto ezisekwe kwisamente.

Ukuphucula ukusebenza kunye nokunamathela kwimiqulu yodaka.

D. Izithambiso:

Iimveliso zokhathalelo lomntu:

Ifunyenwe kwi-creams, i-lotions kunye ne-shampoos ukunceda ukuphucula ukuthungwa kunye nokuzinza.

Isetyenziswe njenge-arhente yokwenza ifilimu kwizinto zokuthambisa.

5. Ukongamela:

Ivunyiwe yi-FDA:

I-L-HPMC ibonwa njengekhuselekile (GRAS) yi-US Food and Drug Administration (FDA).

Ukuthotyelwa kwemigangatho yolawulo kubalulekile ekusetyenzisweni kwayo kumayeza kunye nokutya.

6. Imingeni kunye nezinto ezilindelekileyo kwixesha elizayo:

Ukonakala kwezinto eziphilayo:

Nangona iipolima ezisekwe kwi-cellulose zithathwa ngokuba zinokubola, ubungakanani be-biodegradation yezinto eziphuma kwi-cellulose ezitshintshiweyo zifuna uphando olongezelelweyo.

Uzinzo:

Ukufunwa okuzinzileyo kwemathiriyeli ekrwada kunye neendlela zemveliso ezihambelana nokusingqongileyo ziindawo ekuqhubekeka kujoliswa kuzo.

7. Isiphelo:

I-low-substituted hydroxypropyl methylcellulose ibonisa ubuchule bokuguqulwa kweekhemikhali ekusebenziseni iipropathi zeepolymer zendalo.Ukusetyenziswa kwayo okwahlukeneyo kumashishini ahlukeneyo kubalaselisa ukubaluleka kwayo kwimveliso yanamhlanje.Njengoko ukuqhubela phambili kwetekhnoloji kunye nozinzo kuthatha indawo esembindini, ukuphononongwa okuqhubekayo kunye nokuphuculwa kwe-L-HPMC kunye neekhompawundi ezifanayo zinokubumba ikamva lezinto zesayensi kunye nezenzo zeshishini.