Hydroxypropyl Methyl Cellulose HPMC

IHydroxypropyl methylcellulose(HPMC) iphuma kwi cellulose esetyenziswa ngokuqhelekileyo kumashishini ahlukeneyo, kubandakanywa amayeza, ukutya, ukwakhiwa, kunye nokhathalelo lomntu.Yenziwe ngokuguqula iikhemikhali zeselulosi ngokusebenzisa i-etherification, ebandakanya ukwazisa i-hydroxypropyl kunye namaqela e-methyl kwi-molecule ye-cellulose.

I-HPMC ngumgubo omhlophe ukuya kumhlophe ongenavumba onyibilikayo emanzini kwaye wenze isisombululo esicacileyo, esibonakalayo.Ineempawu ezahlukeneyo ezenza ukuba luncedo kwizicelo ezahlukeneyo.Umzekelo, kukutyeba, ukuzinzisa, kunye ne-emulsifier kwiimveliso zokutya.Ekwakhiweni, isetyenziswe njenge-arhente yokugcina amanzi kwi-samente kunye nodaka ukuze kuphuculwe ukusebenza kunye nokuthintela ukuqhekeka.Kwiimveliso zokhathalelo lomntu, isetyenziswa njenge-thickener kunye ne-emulsifier kwizinto zokuthambisa, iikhrimu, kunye nezinye iimveliso.

Kumachiza, i-HPMC isetyenziswa njenge-binder, i-disintegrant, kunye ne-ejenti elawulwayo yokukhululwa kwiipilisi kunye nee-capsules.Ikwasetyenziswa njenge arhente yokuxhoma ekuxutyweni kolwelo kunye nanjenge-lubricant kwi-ointments kunye ne-creams.I-HPMC yi-excipient eyamkelwa ngokubanzi kwishishini loxubo-mayeza ngenxa yokuhambelana kwayo kwezinto eziphilayo, ukhuseleko, kunye netyhefu ephantsi.

I-HPMC inamabanga amaninzi anamanqanaba ahlukeneyo e-viscosity, atyunjwe ngekhowudi yamanani.Iphezulu inani, iphezulu i-viscosity.Amabakala e-HPMC avela kwi-viscosity ephantsi (5 cps) ukuya kwi-viscosity ephezulu (100,000 cps).I-viscosity ye-HPMC yinto ebalulekileyo ekunqumeni iipropati kunye nokusetyenziswa kwayo.

Ukusetyenziswa kwe-HPMC kumayeza kukhule kule minyaka yakutsha nje ngenxa yeepropathi zayo eziguquguqukayo kunye nokwanda kwemfuno yeenkqubo ezintsha zokuhanjiswa kwamachiza.Ii-hydrogels ezisekelwe kwi-HPMC zisetyenziswe kwiinkqubo zokuhanjiswa kweziyobisi ngenxa yokuhambelana kwazo kwezinto eziphilayo, ukukhululwa okulawulwayo, kunye neempawu ze-mucoadhesive.Iipilisi ezisekelwe kwi-HPMC nazo ziphuhlisiwe ezineempawu eziguqulwayo ezivumela ukuhanjiswa kweyeza ekujoliswe kuzo kunye nokuphuculwa kokuthotyelwa kwesigulane.

Nangona kunjalo, i-HPMC ayikho ngaphandle kwemida yayo.Inonyibiliko obuthathaka kwizinyibilikisi eziphilayo kwaye inovelwano kutshintsho lwe-pH.Ukongezelela, inomlinganiselo wokushisa olinganiselweyo kwaye unokulahlekelwa yi-viscosity kwiqondo lokushisa eliphezulu.Ezi zithintelo ziye zakhokelela ekuphuhliseni ezinye izinto eziphuma kwi-cellulose, ezifana ne-hydroxyethyl cellulose (HEC) kunye ne-carboxymethyl cellulose (CMC), eziye zaphucula iipropati kunye neendawo ezibanzi zokusetyenziswa.

Ukuqukumbela, i-HPMC yimveliso yecellulose esebenza ngeendlela ezininzi esetyenziswa kakhulu kumashishini ahlukeneyo, ngakumbi kumayeza.Iimpawu zayo ezizodwa, kubandakanywa ne-biocompatibility yayo, ukhuseleko, kunye ne-toxicity ephantsi, yenza ukuba i-excipient ethandwayo ekuqulunqweni kweziyobisi.Iinkqubo zokuhanjiswa kweziyobisi ezisekelwe kwi-HPMC zibonise isithembiso ekuphuculeni ukusebenza kwechiza kunye nokuthotyelwa kwesigulane.Nangona kunjalo, ukulinganiselwa kwayo kwi-solubility kunye novelwano lwe-pH kuye kwakhokelela ekuphuhliseni ezinye izinto eziphuma kwi-cellulose ezineempawu eziphuculweyo.