Hydroxypropyl Methyl Cellulose HPMC

Hydroxypropyl methylcellulose(HPMC) ndeye cellulose inobuda iyo inowanzoshandiswa mumaindasitiri akasiyana siyana, kusanganisira mishonga, chikafu, kuvaka, uye kutarisira wega.Iyo inogadzirwa nemakemikari ekugadzirisa cellulose kuburikidza ne etherification, iyo inosanganisira kuunza hydroxypropyl uye methyl mapoka mu cellulose molecule.

HPMC ihupfu huchena husina hwema husina hwema hunonyungudika mumvura uye hunoumba mhinduro yakajeka, ine viscous.Iine zvinhu zvakasiyana-siyana zvinoita kuti zvive zvakakosha mumashandisirwo akasiyana-siyana.Semuenzaniso, inokora, inosimbisa, uye emulsifier muzvigadzirwa zvekudya.Mukuvaka, inoshandiswa sechinhu chekuchengetedza mvura musimende nedhaka kuti ivandudze kushanda uye kudzivirira kuputika.Muzvigadzirwa zvekuchengetedza munhu, inoshandiswa seyakakora uye emulsifier mune lotions, makirimu, uye zvimwe zvigadzirwa.

Mumishonga, HPMC inoshandiswa sebhainda, disintegrant, uye inodzorwa-kuburitsa mumiririri mumapiritsi nemakapisi.Inoshandiswawo seanomisa mumiriri mukugadzirwa kwemvura uye semafuta ekuzora nemafuta.HPMC inogamuchirwa nevakawanda muindasitiri yemishonga nekuda kweiyo biocompatibility, chengetedzo, uye yakaderera chepfu.

HPMC ine mamakisi akati wandei ane akasiyana viscosity mazinga, ayo anosarudzwa nenhamba kodhi.Iyo yakakwirira nhamba, iyo yakakwirira viscosity.HPMC mamakisi kubva pasi viscosity (5 cps) kusvika yakakwirira viscosity (100,000 cps).Iyo viscosity yeHPMC chinhu chakakosha pakuona zvivakwa zvayo uye mashandisirwo.

Iko kushandiswa kweHPMC mumishonga kwakura mumakore achangopfuura nekuda kwekuita zvinhu zvakasiyana-siyana uye kuwedzera kuri kudiwa kwemaitiro matsva ekuendesa zvinodhaka.HPMC-based hydrogels yakashandiswa mumasisitimu ekutumira zvinodhaka nekuda kwekuenderana kwawo, kudzorwa kuburitswa, uye mucoadhesive zvivakwa.Mapiritsi eHPMC-akavakirwa zvakare akagadziridzwa ane akagadziridzwa-kuburitsa zvivakwa zvinobvumira kunangwa kuendesa zvinodhaka uye nekuvandudza kutevedzera kwemurwere.

Nekudaro, HPMC haina miganhu yayo.Iyo ine kushata kunyungudika mune organic solvents uye inonzwa kune pH shanduko.Mukuwedzera, ine hutsika hushoma hwekushisa uye inogona kurasikirwa neviscosity yayo pakupisa kwepamusoro.Izvi zvipingamupinyi zvakatungamira mukugadzirwa kwezvimwe zvinobva kune cellulose, senge hydroxyethyl cellulose (HEC) uye carboxymethyl cellulose (CMC), iyo yakavandudza zvivakwa uye yakafara maseru ekushandisa.

Mukupedzisa, HPMC inosiyana-siyana cellulose derivative iyo inoshandiswa zvakanyanya mumaindasitiri akasiyana, kunyanya mumishonga.Yayo yakasarudzika zvimiro, kusanganisira yayo biocompatibility, chengetedzo, uye yakaderera muchetura, inoita kuti ive yakakurumbira excipient mukugadzira zvinodhaka.HPMC-based drug delivery systems yakaratidza vimbiso mukuvandudza kushanda kwezvinodhaka uye kutevedzera murwere.Nekudaro, izvo zvinogumira mukunyungudika uye pH senitivity zvakatungamira mukuvandudzwa kwezvimwe zvinobva kune cellulose zvine zvivakwa zvakagadziridzwa.